Navigation Links
Macavity wasn't there! How absent reoviruses kill cancer
Date:2/20/2011

Reoviruses are successfully being used in clinical trials to treat patients with cancer. Not only does the virus cause cancer cells to die, it also forces them to release pro-inflammatory chemokines and cytokines, which in turn causes the patient's immune system to attack the disease. New research published by BioMed Central's open access journal Molecular Cancer shows that reovirus infected cancer cells secrete proteins which, even when isolated, result in the death of cancer cells.

Normal human cells are protected from reovirus infection by a protein called PKR. However a cellular signalling protein (Ras), which can block PKR activity, is abnormally activated in many types of cancer and provides a window of opportunity for reovirus infection. A multi-centre study, involving labs in the UK and America, collected growth media from reovirus infected melanoma cells. The researchers showed that this media contained a range of small pro-inflammatory proteins, including an interleukin (IL-8) and Type 1 Interferon (INF-β), which recruited and activated white blood cells, specifically Natural Killer (NK) cells, dendritic cells (DC) and anti melanoma cytotoxic T cells (CTL).

Whilst the exact details behind this mode of action of cell signalling in response to viral infection are unclear, the release of cytokines was dependent on both 'inactive' PKR and a specific nuclear factor (NF-κβ). According to Prof Alan Melcher, from Leeds Institute of Molecular Medicine, "Bystander immune-mediated therapy may well be an important component in the treatment of cancer by reoviruses, and may have potential in treating cancer even in the absence of live virus."


'/>"/>

Contact: Dr. Hilary Glover
hilary.glover@biomedcentral.com
44-203-192-2370
BioMed Central
Source:Eurekalert

Page: 1

Related biology news :

1. Further research needed to develop evidence-based nutrition guidelines for cancer survivors
2. Brupbacher Prize goes to B. Vogelstein and J. Hoeijmakers for research on colorectal and skin cancer
3. Designing new molecular tools to study the life and death of a cancer cell
4. Scientists discover cell of origin for childhood muscle cancer
5. Jefferson researchers provide genetic evidence that antioxidants can help treat cancer
6. U of Alberta researcher discovers potential cancer therapy target
7. Offspring of female rats given folic acid supplements develop more breast cancer
8. Cancer breakthrough to prevent heart failure and increase survival rates
9. Photodynamic therapy against cancer
10. Sweeping view of prostate cancer genome yields deep insights
11. Research team honored for innovative science to advance cancer research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... 2017   Bridge Patient Portal , an ... MD EMR Systems , an electronic medical record ... have established a partnership to build an interface ... GE Centricity™ products, including Centricity Practice Solution (CPS), ... These new integrations will allow healthcare delivery networks ...
(Date:4/17/2017)... 17, 2017 NXT-ID, Inc. (NASDAQ: NXTD ... filing of its 2016 Annual Report on Form 10-K on Thursday ... ... available in the Investor Relations section of the Company,s website at ... website at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... No two people are believed to ... York University Tandon School of Engineering and Michigan ... partial similarities between prints are common enough that ... and other electronic devices can be more vulnerable ... in the fact that fingerprint-based authentication systems feature ...
Breaking Biology News(10 mins):
(Date:6/28/2017)... , ... June 28, 2017 , ... Supplies of the ... leading experts gathered at the Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2017 ... technetium-99m (Tc-99m), which is used in 30 to 40 million nuclear medicine procedures worldwide ...
(Date:6/27/2017)... ... 27, 2017 , ... The recent vote by the American Medication Association to ... hope to patients and hopefully sheds new light on the way health insurers, governments ... expert and founding partner of Texas Fertility Center . , “This designation ...
(Date:6/27/2017)... ... , ... Biodex Medical Systems, Inc. announces the release of the Mobility Assist, ... lifts patients safely from a seated to a standing position without staff support using ... the latest in a line of Biodex products promoting safe patient handling. , The ...
(Date:6/27/2017)... ... June 27, 2017 , ... Indiana-based Xylogenics announced today the ... fermentation process. The efficiencies created by the newest strain design will have ... ethanol industry wherein individual production plants are planning to invest upwards of $350 ...
Breaking Biology Technology: