Navigation Links
MU scientists successfully transplant, grow stem cells in pigs
Date:6/4/2014

COLUMBIA, Mo. One of the biggest challenges for medical researchers studying the effectiveness of stem cell therapies is that transplants or grafts of cells are often rejected by the hosts. This rejection can render experiments useless, making research into potentially life-saving treatments a long and difficult process. Now, researchers at the University of Missouri have shown that a new line of genetically modified pigs will host transplanted cells without the risk of rejection.

"The rejection of transplants and grafts by host bodies is a huge hurdle for medical researchers," said R. Michael Roberts, Curators Professor of Animal Science and Biochemistry and a researcher in the Bond Life Sciences Center. "By establishing that these pigs will support transplants without the fear of rejection, we can move stem cell therapy research forward at a quicker pace."

In a published study, the team of researchers implanted human pluripotent stem cells in a special line of pigs developed by Randall Prather, an MU Curators Professor of reproductive physiology. Prather specifically created the pigs with immune systems that allow the pigs to accept all transplants or grafts without rejection. Once the scientists implanted the cells, the pigs did not reject the stem cells and the cells thrived. Prather says achieving this success with pigs is notable because pigs are much closer to humans than many other test animals.

"Many medical researchers prefer conducting studies with pigs because they are more anatomically similar to humans than other animals, such as mice and rats," Prather said. "Physically, pigs are much closer to the size and scale of humans than other animals, and they respond to health threats similarly. This means that research in pigs is more likely to have results similar to those in humans for many different tests and treatments."

"Now that we know that human stem cells can thrive in these pigs, a door has been opened for new and exciting research by scientists around the world," Roberts said. "Hopefully this means that we are one step closer to therapies and treatments for a number of debilitating human diseases."


'/>"/>

Contact: Nathan Hurst
hurstn@missouri.edu
573-882-6217
University of Missouri-Columbia
Source:Eurekalert  

Related biology news :

1. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
2. Queens scientists seek vaccine for Pseudomonas infection
3. Scientists produce eye structures from human blood-derived stem cells
4. American Society of Plant Biologists honors early career women scientists
5. Brandeis scientists win prestigious prize for circadian rhythms research
6. Scientists discover new method of proton transfer
7. Salk scientists open new window into how cancers override cellular growth controls
8. WileyChina.com - Now Featuring Bespoke Pages for China’s Life Scientists
9. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
10. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
11. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
MU scientists successfully transplant, grow stem cells in pigs
(Date:2/2/2019)... N.C. (PRWEB) , ... January ... ... a clinical research organization headquartered in Morrisville, NC, providing full, customizable clinical ... with LaunchBio, Inc. to support educational programs for early stage life science ...
(Date:1/25/2019)... ... January 24, 2019 , ... ... of its 2019 Association Industry Survey. The report indicates membership growth in some ... mid-November to early December 2018, received responses from over 500 association professionals across ...
(Date:1/20/2019)... ... , ... As the leader in 3D cell culture characterization and analysis, Visikol ... cell culture models. In an effort to build a consensus in the market, Visikol ... researcher can replicate these models for their internal research efforts. , Recently, researchers ...
Breaking Biology News(10 mins):
(Date:1/20/2019)... ... 17, 2019 , ... Consumers are directing healthcare in many ... That's changing as many services now exist for patients to order tests without ... $208 million in 2018, according to Kalorama Information’s new report, The Direct-To-Consumer ...
(Date:1/15/2019)... BROOK, Ill. (PRWEB) , ... January 15, 2019 , ... ... risk factors for worsening kidney disease, according to a new study published in the ... stage and are frequently treated with partial nephrectomy, a surgical procedure in which the ...
(Date:1/10/2019)... ... ... a local shelter when he was around two years old. According to his mom, ... was adopted, he tore his right cruciate ligament. Though he had his ACL surgically ... injury. , Sure enough, when Rascal was about nine years old, he began showing symptoms ...
(Date:1/8/2019)... ... 2019 , ... The American Society of Gene and Cell Therapy’s ... committee made up of industry leaders identified by the ASGCT board of directors. In ... created to support ASGCT members designing transformative pilot studies in gene and cell therapy ...
Breaking Biology Technology: