Navigation Links
MU scientists 'see' how HIV matures into an infection
Date:10/1/2008

COLUMBIA, Mo. After improving the sensitivity of nuclear magnetic resonance (NMR), researchers at the University of Missouri actually watched the HIV-1 protease mature from an inactive form into an active infection. This process has never been directly visualized before. The findings appear today in the journal Nature.

"We actually saw the process occur," said Chun Tang, assistant professor of biochemistry in the MU School of Medicine. "This is something that has never been done before. We now understand more about the maturation process. We hope this will be a stepping stone to intervening before the infection progresses."

The HIV-1 protease is responsible for releasing the essential building blocks of an infective HIV-1 viral particle, the culprit of AIDS. The HIV-1 protease is one of the primary targets of therapeutic treatment. However, the viral enzyme is constantly mutating in an effort to gain drug resistance.

"HIV-1 protease is not an active enzyme when it is first expressed in cells. It has to be activated to do its job," Tang said. "What we were able to see is how it self-activates from an immature form when the virus is not infective into a mature form when the virus gains infectivity."

Tang and his colleagues used a novel NMR method called paramagnetic resonance relaxation enhancement and were able to see the temporary joining of two halves of HIV-1 protease precursor, something that had not been accessible before using conventional techniques.

The researchers discovered that the 'tail,' or the flanking amino acid residues, of the HIV-1 protease precursor go through a temporarily formed tunnel where the tail is cut off. At this point, the protease becomes active, the maturation process proceeds, and the virus becomes infective.

"The more we understand about the virus, especially about the maturation into infection, the more we can do to identify novel therapeutics," Tang said.


'/>"/>

Contact: Jennifer Faddis
Faddisj@missouri.edu
573-882-6217
University of Missouri-Columbia
Source:Eurekalert

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... -- Delta (NYSE: DAL ) customers now can use fingerprints ... Washington National Airport (DCA). ... Delta launches biometrics to board aircraft at Reagan Washington National ... Delta,s biometric boarding pass experience that launched ... into the boarding process to allow eligible Delta SkyMiles Members who are ...
(Date:6/30/2017)... Today, American Trucking Associations announced Seeing ... and eye tracking software, became the newest member ... "Artificial intelligence and advanced sensing algorithms ... driver,s attentiveness levels while on the road.  Drivers ... fatigue and prevent potential accidents, which could lead ...
(Date:6/23/2017)... ITHACA, N.Y. , June 23, 2017 ... a leader in dairy research, today announced a new ... help reduce the chances that the global milk supply ... this dairy project, Cornell University has become the newest ... Food Supply Chain, a food safety initiative that includes ...
Breaking Biology News(10 mins):
(Date:7/28/2017)... ... July 28, 2017 , ... ... provider, announces BiobankPro®, a workflow based enterprise solution for next-generation biobanking. BiobankPro ... freezer centered, BiobankPro® offers a solution that is specimen centered. , “Your ...
(Date:7/27/2017)... ... July 27, 2017 , ... ... a Top 100 Agency award by Medical Marketing & Media magazine ... , According to its website, MM&M “is the media brand of record for ...
(Date:7/27/2017)... , ... July 27, 2017 , ... ... sexual characteristics, but it is also synthesized in female at a much lower ... women with hirsutism, virilization, oligomenorrhea, and possible testosterone deficiency in women. , ...
(Date:7/27/2017)... ... July 27, 2017 , ... Cynvenio Biosystems, Inc. ... today announced that its LiquidBiopsy rare cell and cell-free isolation platform has been ... Seoul, Severance Hospital is one of the oldest and largest university hospitals in ...
Breaking Biology Technology: