Navigation Links
MU scientists 'see' how HIV matures into an infection
Date:10/1/2008

COLUMBIA, Mo. After improving the sensitivity of nuclear magnetic resonance (NMR), researchers at the University of Missouri actually watched the HIV-1 protease mature from an inactive form into an active infection. This process has never been directly visualized before. The findings appear today in the journal Nature.

"We actually saw the process occur," said Chun Tang, assistant professor of biochemistry in the MU School of Medicine. "This is something that has never been done before. We now understand more about the maturation process. We hope this will be a stepping stone to intervening before the infection progresses."

The HIV-1 protease is responsible for releasing the essential building blocks of an infective HIV-1 viral particle, the culprit of AIDS. The HIV-1 protease is one of the primary targets of therapeutic treatment. However, the viral enzyme is constantly mutating in an effort to gain drug resistance.

"HIV-1 protease is not an active enzyme when it is first expressed in cells. It has to be activated to do its job," Tang said. "What we were able to see is how it self-activates from an immature form when the virus is not infective into a mature form when the virus gains infectivity."

Tang and his colleagues used a novel NMR method called paramagnetic resonance relaxation enhancement and were able to see the temporary joining of two halves of HIV-1 protease precursor, something that had not been accessible before using conventional techniques.

The researchers discovered that the 'tail,' or the flanking amino acid residues, of the HIV-1 protease precursor go through a temporarily formed tunnel where the tail is cut off. At this point, the protease becomes active, the maturation process proceeds, and the virus becomes infective.

"The more we understand about the virus, especially about the maturation into infection, the more we can do to identify novel therapeutics," Tang said.


'/>"/>

Contact: Jennifer Faddis
Faddisj@missouri.edu
573-882-6217
University of Missouri-Columbia
Source:Eurekalert

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/11/2016)... , Jan. 11, 2016 Synaptics Incorporated ... interface solutions, today announced that its ClearPad ® ... (TDDI) products won two separate categories in the 8 ... Innovator and Best Technology Breakthrough. The Synaptics ® ... a simplified supply chain, thinner devices, brighter displays and ...
(Date:1/8/2016)... 8, 2016 NXTD ), a ... ® , a privately held leading direct seller of ... 5000 fastest-growing company announced that on December 31, ... million in Nxt-ID to develop a proprietary new wireless ... ® , a unique smart wallet that serves to ...
(Date:1/7/2016)... 7, 2016  A United States District Court in ... in the country to interpret a biometric privacy statute ... forward against the photo website Shutterfly brought by the law ... NORBERG vs. SHUTTERFLY, INC.; and THISLIFE, INC ( ... Shutterfly violates the Illinois Biometric Privacy Act by collecting ...
Breaking Biology News(10 mins):
(Date:2/5/2016)... DIEGO , Feb. 5, 2016 On ... region,s trusted information source for community, health and disaster ... Diego) will integrate to enhance care coordination and ... to the services they need and to better connect ... improve care.   San Diego ...
(Date:2/4/2016)... - New FDA action date of July 22, ... July 22, 2016   --> - ...   - Lifitegrast has the potential to be the ... signs and symptoms of dry eye disease in adults ... product approved in the U.S. in the past decade indicated for the treatment of ...
(Date:2/4/2016)... , Feb. 4, 2016 Beike Biotechnology, ... various medical institutions attended a ceremony in late 2015 ... personalized cell therapy in 2016. --> ... Clinical Translation Platform for Personalized Cell Therapy" was hosted ... Cell Production Center, both subsidiaries of Beike Biotechnology Co., ...
(Date:2/4/2016)... EDISON, N.J. , Feb. 4, 2016 ... company focused on the development and commercialization of targeted ... BIO CEO & Investor Conference 2016, to be held ... and Source Capital Group,s 2016 Disruptive Growth & Healthcare ... on February 10-11, 2016. James Sapirstein ...
Breaking Biology Technology: