Navigation Links
MU scientist eyeing enzymes that could help fight flu
Date:11/17/2011

The influenza virus remains a worldwide threat to humans, causing an average of 36,000 deaths and 200,000 hospitalizations each year in the United States alone. As health care professionals prepare for another flu season, a University of Missouri scientist is studying how two enzymes could be used to stop the virus in its tracks.

Bumsuk Hahm, PhD, and his colleagues at MU have received a $1.8 million grant from the National Institutes of Health to examine how the enzymes influence the immune system's ability to fight infection. Called sphingosine 1-phosphate lyase (SPL) and sphingosine kinase 1 (SK1), they are among a group of metabolizing enzymes that affect many cellular processes, including cell growth, survival, movement and specialization.

"We know these enzymes influence multiple biological mechanisms and could lead to promising drug candidates, but scientists have never studied how these enzymes could be used to fight influenza," said Hahm, an assistant professor of surgery, molecular microbiology and immunology. "There are a lot of seasonal flu strains that are resistant to current treatments, including some strains could cause a global pandemic, so it's important that we identify and develop new targets for the treatment of influenza."

In a study published in the Journal of Virology, Hahm's research revealed that the enzymes affect the immune system's ability to detect viruses and resist infection. The new NIH grant will allow him to translate his study from cells to mice, an important step toward the development of a new treatment for humans.

"We found that when we alter the enzymes, the SPL enzyme stops the flu virus' ability to replicate, while the SK1 enzyme helps the virus to replicate," Hahm said. "If we can specifically activate SPL or inhibit SK1, we can identify a target for drug therapies that will block the spread of the influenza virus."

In November 2011, the MU School of Medicine presented Hahm with its most prestigious award for scientists, the Dorsett L. Spurgeon Distinguished Medical Research Award. Hahm received his doctorate in molecular virology from Pohang University of Science and Technology in South Korea and then joined the virology division at the Scripps Research Institute in La Jolla, Calif. At Scripps, Dr. Hahm studied viral immunology and viral pathogenesis before joining the MU School of Medicine as a faculty member in 2008.


'/>"/>
Contact: Laura Gerding, APR
gerdingla@health.missouri.edu
573-882-9193
University of Missouri School of Medicine
Source:Eurekalert  

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientist plans to test for blood pressure genes affected by age
3. Scientists identify novel inhibitor of human microRNA
4. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
5. MU scientists go green with gold, distribute environmentally friendly nanoparticles
6. Scientists identify gene that may contribute to improved rice yield
7. Scientists discover why a mothers high-fat diet contributes to obesity in her children
8. MU scientists see how HIV matures into an infection
9. Earth scientists keep an eye on Texas
10. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
11. Scientists identify a molecule that coordinates the movement of cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
MU scientist eyeing enzymes that could help fight flu
(Date:3/22/2016)... OTTAWA, Ontario , PROVO ... 2016 Newborn Screening Ontario (NSO), which operates ... for molecular testing, and Tute Genomics and ... process management technology respectively, today announced the launch of ... new next-generation sequencing (NGS) testing panel. ...
(Date:3/17/2016)... 2016 ABI Research, the leader in ... biometrics market will reach more than $30 billion ... 2015. Consumer electronics, particularly smartphones, continue to boost ... to reach two billion shipments by 2021 at ... , Research Analyst at ABI Research. "Surveillance is ...
(Date:3/14/2016)... , March 14, 2016 NXTD ) ... mobile commerce market, announces the airing of a new series ... the week of March 21 st .  The commercials will ... its popular Squawk on the Street show. --> ... the growing mobile commerce market, announces the airing of a ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... 28, 2016 Q BioMed ... Company,s CEO  was featured in an article he ... VCs Fear To Tread: http://www.lifescienceleader.com/doc/accelerators-enter-when-vcs-fear-to-tread-0001 ... is an essential business journal for life ... biotechs to Big Pharmas. Their content is designed ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... in recruiting top industry experts, and expanding its LATAM network and logistics capabilities. ... for clients to manage their clinical trial projects. , The expansion will provide ...
(Date:4/27/2016)... (PRWEB) , ... April 27, 2016 , ... ... of cannabis testing technology at the Spring 2016 Marijuana Business Conference and Expo. ... pesticides, residual solvents, heavy metals, and more. Expo attendees can stop by booth ...
(Date:4/27/2016)... Columbia , April 27, 2016 ... "NanoStruck") (CSE: NSK) (OTCPink: NSKQB) ( Frankfurt ... Anschluss an ihre Pressemitteilung vom 13. August 2015 ... hat, ihre Finanzen um zusätzliche 200.000.000 Einheiten auf ... Kanadische Dollar zu bringen. Davon wurden 157.900.000 Einheiten ...
Breaking Biology Technology: