Navigation Links
MU researchers find condition in dogs that may help further research into human disease
Date:7/9/2013

COLUMBIA, Mo. Some people possess a small number of cells in their bodies that are not genetically their own; this condition is known as microchimerism. It is difficult to determine potential health effects from this condition because of humans' relatively long life-spans. Now, researchers at the University of Missouri have found that microchimerism can be found in dogs as well. Jeffrey Bryan, an associate professor of oncology at the MU College of Veterinary Medicine and director of Comparative Oncology and Epigenetics Laboratory, says this discovery will help doctors determine what diseases humans with microchimerism may be more likely to develop during their lifetimes.

"Dogs have a much shorter lifespan than humans, which allows us, as researchers, to better monitor what diseases they may develop throughout their entire lives," Bryan said. "We already have some evidence that microchimerism may increase risk of thyroid disease while lowering the risk of breast cancer in women. Finding microchimerism in dogs allows us to track this condition over a lifespan of about 10 years, as opposed to the 70 or 80 years of a human life. This will make it much easier to determine any increased risk of or protection from other diseases brought on by microchimerism."

"Our study demonstrates that male microchimerism of probable fetal origin occurs in the pet dog population," said Sandra Axiak-Bechtel, an assistant professor of oncology at the MU College of Veterinary Medicine. "Evidence exists in women that fetal microchimerism may have conflicting roles in disease formation. The pet dog represents an excellent model of many ailments in people, and the presence of fetal microchimerism in dogs will allow studies which further clarify its role in health and disease."

Microchimerism most often occurs when a mother gives birth to a child. Sometimes, cells from that child are left in the mothers' body and continue to live, despite being of a different genetic makeup than surrounding cells. Those cells can then be passed on to other children the mother may have later. Cells also can be passed on through blood transfusions as well as bone marrow and organ transplants.

In their study published in PLOS ONE, Bryan and Axiak-Bechtel, along with MU researchers Senthil Kumar, a co-investigator in this study and assistant research professor and assistant director of the Comparative Oncology and Epigenetics Laboratory, and Sara Hansen, a comparative medicine resident at MU, studied 90 golden retrievers and found that 36 percent of the dogs had microchimerism. Closer to 40 percent of female dogs that were at least eight years post-pregnancy had the condition.

Axiak-Bechtel, Bryan, and Kumar plan on continuing their research to follow the lifespans of dogs with microchimerism to determine to what diseases those dogs may be susceptible. Bryan and Kumar also received a new grant for more than $400,000 to study epigenetic biomarkers in dogs, which will ultimately enhance diagnosis and treatment of dogs with cancer.


'/>"/>

Contact: Nathan Hurst
hurstn@missouri.edu
573-882-6217
University of Missouri-Columbia
Source:Eurekalert

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market by ... Service, Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast to ... USD 14.30 Billion in 2017 to USD 31.75 Billion by 2022, at ... ... MarketsandMarkets Logo ...
(Date:4/6/2017)... April 6, 2017 Forecasts by ... Document Readers, by End-Use (Transportation & Logistics, Government & ... Gas & Fossil Generation Facility, Nuclear Power), Industrial, Retail, ... Are you looking for a definitive report ... ...
(Date:4/3/2017)... , April 3, 2017  Data captured ... engineering platform, detected a statistically significant association ... prior to treatment and objective response of ... potential to predict whether cancer patients will ... treatment, as well as to improve both pre-infusion ...
Breaking Biology News(10 mins):
(Date:5/18/2017)... ... 2017 , ... Dr. Ralph Mobbs of the Neuro Spine ... Private Hospital. The procedure was performed on a 46-year-old male patient suffering from ... to undergoing surgery. , The AxioMed viscoelastic disc is a next-generation disc replacement ...
(Date:5/18/2017)... ... May 16, 2017 , ... Clinical Supplies Management (“CSM”), a Great ... company continues to grow. CSM has doubled in size over the past six ... aggressive growth strategy. , Roger Gasper joins CSM as Chief Financial Officer. Roger ...
(Date:5/18/2017)... , ... May 17, 2017 ... ... standards with psychonneuroendocrine stress expertise, and further enhances its scientific power by ... Douglas A. Granger, Ph.D., has agreed to join the scientific advisory board. ...
(Date:5/18/2017)... ... May 17, 2017 , ... USDM Life Sciences , ... life sciences and healthcare industries, is honored that Jay Crowley was ... in Brussels, Belgium. , Crowley played a crucial role in the development of ...
Breaking Biology Technology: