Navigation Links
MU researcher receives $1.5 Million NIH grant to study vascular functions in Alzheimer's
Date:5/21/2014

COLUMBIA, Mo. Alzheimer's is a progressive brain disease that affects older adults, slowly destroys their memories and may cause dementia. According to estimates from the National Institutes of Health (NIH), the disease may affect as many as 5.1 million Americans. Now, with the help of a $1.5 million grant from the NIH, University of Missouri researcher James Lee will continue to look for clues into the causes of Alzheimer's.

"Alzheimer's is an extremely complex disease," said Lee, an associate professor of bioengineering in the MU College of Engineering. "Our research team focuses on a protein, amyloid-beta peptide, which is present at toxic levels in the brains of Alzheimer's patients. We hope to find links between the peptide and the inevitable damage to blood capillaries in the brain."

In the brains of Alzheimer's patients, amyloid-beta peptide (A-beta) adversely interacts with astrocytes, or star-shaped cells that provide structural and metabolic support to neurons and control transmissions in the brain. Astrocytes also provide maintenance to the blood-brain barrier, which protects the brain from harmful neurotoxins and infections.

Lee and his collaborator, Grace Sun, a professor in the Department of Biochemistry at MU, are using biophysical engineering techniques, including atomic force microscopy, which is an instrument that probes and measures cell mechanics with sharp tips. Information is then collected and analyzed to determine how the cells function. Lee's study will focus on how A-beta interacts with cerebral endothelial cells, resulting in the change of cell function.

"When A-beta interacts with blood capillaries in brains affected by Alzheimer's, cell signalings occur that essentially cause capillaries to break down," Lee said. "Until now, this key vascular factor leading to neuronal degeneration in the brain has been understudied. The grant provided by the NIH will help us add novel information about Alzheimer's, and our findings will help inform future research as we look for treatments and cures."


'/>"/>

Contact: Jeff Sossamon
sossamonj@missouri.edu
573-882-3346
University of Missouri-Columbia
Source:Eurekalert  

Related biology news :

1. Illinois researchers combine weak chemical forces to strengthen novel imaging technology
2. NHAES researchers receive $482,500 grant to study nitrogen loss in soils
3. Researchers test whether Red Queen hypothesis makes species resilient
4. NIH researchers discover key factor in early auditory system development
5. Eskitis links with European life science researchers
6. Researchers identify link between colon cancer and metabolism
7. Researchers find a new gene expression mechanism of PRRS virus
8. Researchers find new molecule to treat asthma
9. JAX researchers identify potential therapeutic target for wound-healing and cancer
10. Henry Ford researchers identify genetic factors that may aid survival from brain cancer
11. Oregon researchers capture handoff of tracked object between brain hemispheres
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
MU researcher receives $1.5 Million NIH grant to study vascular functions in Alzheimer's
(Date:5/6/2017)... 2017 RAM Group , Singaporean ... breakthrough in biometric authentication based on a ... to perform biometric authentication. These new sensors are based ... by Ram Group and its partners. This sensor will ... chains and security. Ram Group is a next ...
(Date:4/13/2017)... , April 13, 2017 UBM,s Advanced ... will feature emerging and evolving technology through ... Innovation Summits will run alongside the expo portion of ... sessions, panels and demonstrations focused on trending topics within ... advanced design and manufacturing event will take place June ...
(Date:4/11/2017)... Florida , April 11, 2017 ... a security technology company, announces the appointment of independent Directors ... Bendheim to its Board of Directors, furthering the company,s ... ... of NXT-ID, we look forward to their guidance and benefiting ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... (PRWEB) , ... July 20, 2017 , ... ... on health-related quality of life, today announced its full advisory board. The board ... announced the promotion of James Crooks, PhD, former VP of Engineering, to Chief ...
(Date:7/20/2017)... ... July 20, 2017 , ... Crucial Data Solutions ... and study participants truly unified. TrialKit, a native mobile app, empowers investigators and ... research studies entirely on mobile devices. With TrialKit, clinical researchers can utilize Core ...
(Date:7/18/2017)... , ... July 18, 2017 , ... Blood centers traditionally ... across the region. Nationally, summer is a struggle for community blood centers as high ... San Antonio Chamber of Commerce is teaming up with the South ...
(Date:7/17/2017)... Doylestown, Pa. (PRWEB) , ... ... ... leading provider of technology-enabled clinical trial solutions, today announced safety software company ... channel within the eHealth Solutions business segment to advance technology innovation across ...
Breaking Biology Technology: