Navigation Links
MU researcher receives $1.5 Million NIH grant to study vascular functions in Alzheimer's
Date:5/21/2014

COLUMBIA, Mo. Alzheimer's is a progressive brain disease that affects older adults, slowly destroys their memories and may cause dementia. According to estimates from the National Institutes of Health (NIH), the disease may affect as many as 5.1 million Americans. Now, with the help of a $1.5 million grant from the NIH, University of Missouri researcher James Lee will continue to look for clues into the causes of Alzheimer's.

"Alzheimer's is an extremely complex disease," said Lee, an associate professor of bioengineering in the MU College of Engineering. "Our research team focuses on a protein, amyloid-beta peptide, which is present at toxic levels in the brains of Alzheimer's patients. We hope to find links between the peptide and the inevitable damage to blood capillaries in the brain."

In the brains of Alzheimer's patients, amyloid-beta peptide (A-beta) adversely interacts with astrocytes, or star-shaped cells that provide structural and metabolic support to neurons and control transmissions in the brain. Astrocytes also provide maintenance to the blood-brain barrier, which protects the brain from harmful neurotoxins and infections.

Lee and his collaborator, Grace Sun, a professor in the Department of Biochemistry at MU, are using biophysical engineering techniques, including atomic force microscopy, which is an instrument that probes and measures cell mechanics with sharp tips. Information is then collected and analyzed to determine how the cells function. Lee's study will focus on how A-beta interacts with cerebral endothelial cells, resulting in the change of cell function.

"When A-beta interacts with blood capillaries in brains affected by Alzheimer's, cell signalings occur that essentially cause capillaries to break down," Lee said. "Until now, this key vascular factor leading to neuronal degeneration in the brain has been understudied. The grant provided by the NIH will help us add novel information about Alzheimer's, and our findings will help inform future research as we look for treatments and cures."


'/>"/>

Contact: Jeff Sossamon
sossamonj@missouri.edu
573-882-3346
University of Missouri-Columbia
Source:Eurekalert  

Related biology news :

1. Illinois researchers combine weak chemical forces to strengthen novel imaging technology
2. NHAES researchers receive $482,500 grant to study nitrogen loss in soils
3. Researchers test whether Red Queen hypothesis makes species resilient
4. NIH researchers discover key factor in early auditory system development
5. Eskitis links with European life science researchers
6. Researchers identify link between colon cancer and metabolism
7. Researchers find a new gene expression mechanism of PRRS virus
8. Researchers find new molecule to treat asthma
9. JAX researchers identify potential therapeutic target for wound-healing and cancer
10. Henry Ford researchers identify genetic factors that may aid survival from brain cancer
11. Oregon researchers capture handoff of tracked object between brain hemispheres
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
MU researcher receives $1.5 Million NIH grant to study vascular functions in Alzheimer's
(Date:11/21/2016)...   Neurotechnology , a provider of high-precision ... that the MegaMatcher On Card fingerprint matching algorithm ... NIST Minutiae Interoperability Exchange (MINEX) III ... of the evaluation protocol. The ... fingerprint templates used to establish compliance of template ...
(Date:11/15/2016)... 15, 2016  Synthetic Biologics, Inc. (NYSE MKT: ... on the gut microbiome, today announced the pricing ... of its common stock and warrants to purchase ... price to the public of $1.00 per share ... from the offering, excluding the proceeds, if any ...
(Date:6/22/2016)... 2016  The American College of Medical Genetics and Genomics ... as one of the fastest-growing trade shows during the ... Bellagio in Las Vegas . ... growth in each of the following categories: net square feet ... of attendees. The 2015 ACMG Annual Meeting was ranked 23 ...
Breaking Biology News(10 mins):
(Date:11/30/2016)... 30, 2016  The Allen Institute for Cell ... first publicly available collection of gene edited, fluorescently ... key cellular structures with unprecedented clarity. Distributed through ... tools are a crucial first step toward visualizing ... what makes human cells healthy and what goes ...
(Date:11/30/2016)... Nov. 30, 2016  Tempus, a technology company ... and Penn,s Abramson Cancer Center have partnered to ... response to immunotherapy treatment based on next generation ... part of a research collaboration, Tempus will provide ... cancer patient data to Penn. Utilizing next-generation sequencing, ...
(Date:11/30/2016)... 2016   Merck , ein führendes ... einer Reihe von Vereinbarungen mit Evotec AG ... Screeningleistungen für Mercks Palette genetischer Reagenzien wie ... diese Bibliotheken in Kombination mit Evotecs Expertise ... zur Ermittlung und Erforschung neuer Arzneimitteltargets.    ...
(Date:11/30/2016)... BILLERICA, Mass. , Nov. 30, 2016   ... announced that it has entered into a set of ... screening services for Merck,s collection of genetic reagents such ... libraries with Evotec,s screening expertise offers an accelerated pathway ... "Drug discovery starts with the identification of new targets, ...
Breaking Biology Technology: