Navigation Links
MU research sheds light on nerve regeneration following spinal cord injury
Date:11/21/2013

COLUMBIA, Mo. Fish, unlike humans, can regenerate nerve connections and recover normal mobility following an injury to their spinal cord. Now, University of Missouri researchers have discovered how the sea lamprey, an eel-like fish, regrows the neurons that comprise the long nerve "highways" that link the brain to the spinal cord. Findings may guide future efforts to promote recovery in humans who have suffered spinal cord injuries.

"There is a lot of attention to why, following a spinal cord injury, neurons regenerate in lower vertebrates, such as the sea lamprey, and why they don't in higher vertebrates, such as humans," said Andrew McClellan, professor of biological sciences in the College of Arts and Science and director of the MU Spinal Cord Injury Program.

The study focuses on the regrowth of a particular group of nerve cells called reticulospinal neurons, which are necessary for locomotion. These neurons are found in the hindbrain, or the brainstem, and send signals to the spinal cord of all vertebrates to control movements of the body, such as locomotor behavior. When these nerve cells are damaged by a spinal cord injury, the animal is unable to move below the level of injury. While humans and other higher vertebrates would be permanently paralyzed, the sea lamprey and other lower vertebrates have the ability to regrow these neurons and recover the ability to move within a few short weeks.

In the study, McClellan and his colleagues isolated and removed injured reticulospinal neurons from sea lamprey and grew them in cultures. They applied chemicals that activated a group of molecules, called second messengers, to see what effects they had on these neurons' growth. They discovered that activation of cyclic AMP, a molecule that relays chemical signals inside cells, acted somewhat like an "on" switchessentially converting neurons from a non-growing state to a growing one. However, it had no effect on neurons that had already
'/>"/>

Contact: Jeff Sossamon
sossamonj@missouri.edu
573-882-3346
University of Missouri-Columbia
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Researchers gain fuller picture of cell protein reactions
2. Scripps oceanography researchers engineer breakthrough for biofuel production
3. USF researchers show invasive sparrows immune cells sharpen as they spread
4. Researchers use CT and 3-D printers to recreate dinosaur fossils
5. Natural compound mitigates effects of methamphetamine abuse, University of Missouri researchers find
6. Researchers classify urban residential desert landscapes
7. Researchers test effects of LEDs on leaf lettuce
8. Researchers develop new approach to identify possible ecological effects of releasing genetically engineered insects
9. Researchers capture structure of key part of deadly Nipah virus
10. Researchers identify main genes responsible for asthma attacks in children
11. Bait research focused on outsmarting destructive beetle
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
MU research sheds light on nerve regeneration following spinal cord injury
(Date:9/29/2014)... Food and Brand Lab pilot study, published in ... National School Lunch Program (NSLP) by 9% and overall ... Move to Schools (CMTS), an initiative of Michelle Obama,s ... to provide nutrition instruction to students and culinary advice ... event was held in an Upstate New York high ...
(Date:9/29/2014)... PULLMAN, Wash. Scientists at Washington State University ... specifically, Granny Smith apples may help prevent ... be the first to assess these compounds in ... in October,s print edition of the journal ... apples are a good source of these nondigestible ...
(Date:9/29/2014)... decades, planetary geologists have speculated that glaciers might ... chasm that constitutes the Grand Canyon of Mars. ... might have been carved by past glaciers as ... have remained highly controversial and contested. , ... and the Freie Universitaet Berlin has identified what ...
Breaking Biology News(10 mins):Chefs move to schools can increase school meal participation and vegetable intake among students 2An apple a day could keep obesity away 2Glaciers in the Grand Canyon of Mars? 2Glaciers in the Grand Canyon of Mars? 3Glaciers in the Grand Canyon of Mars? 4Glaciers in the Grand Canyon of Mars? 5Glaciers in the Grand Canyon of Mars? 6Glaciers in the Grand Canyon of Mars? 7Glaciers in the Grand Canyon of Mars? 8Glaciers in the Grand Canyon of Mars? 9
... thousands of people suffer medical complications from hypodermic needles ... device developed by MIT engineers and colleagues aims to ... The device, which is purely mechanical, is based ... a hollow S-shaped needle containing a filament that acts ...
... that gives greatest protection from heart attack and stroke. In ... researchers showed that one, DHPEA-EDA, protects red blood cells from ... "These findings provide the scientific basis for the clear health ... oil in their diet," says lead researcher Fatima Paiva-Martins, who ...
... have come to agree that different environments impact the ... University of British Columbia are showing for the first ... from the UBC Biodiversity Research Centre created mini-ecosystems in ... fish and saw substantial differences in the ecosystems in ...
Cached Biology News:MIT: Novel needle could cut medical complications 2UBC study first to show evolution's impact on ecosystems 2
(Date:9/29/2014)... METTLER TOLEDO’s new line of XPE balances includes ... balances as well as automated dosing with the ... out their daily weighing tasks worry free, safe in ... reliable and compliant results, thanks to new technologies such ... biggest challenges in analytical and micro-analytical weighing – electrostatic ...
(Date:9/29/2014)... 29, 2014  Perrigo Company plc (NYSE: ... has transferred a portfolio of preclinical research assets, ... of Elan Corporation plc, to drug discovery and ... agreement, Perrigo will receive an upfront payment in ... on any future sales derived from the portfolio. ...
(Date:9/29/2014)... September 29, 2014 Westbridge Agricultural ... Herbicide EC, a highly effective new tool for ... a broad spectrum contact herbicide for post-emergent, non-selective ... and non-food crops. The formulation is an emulsifiable ... Materials Review Institute (OMRI) for use in organic ...
(Date:9/27/2014)... This news release is available in German . ... electron microscope is not only used for precisely surveying ... their chemical compositions. This is done by exciting the ... while scanning the sample. This secondary emission provides information ... the analysis is sufficiently precise. However, the lighter elements ...
Breaking Biology Technology:New Line of XPE Balances from METLER TOLEDO is Designed for High Performance and Ease of Compliance 2Perrigo Announces the Out-Licensing of Preclinical Assets to Imago Pharmaceuticals 2Perrigo Announces the Out-Licensing of Preclinical Assets to Imago Pharmaceuticals 3Perrigo Announces the Out-Licensing of Preclinical Assets to Imago Pharmaceuticals 4Westbridge Receives EPA Approval for Its New SUPPRESS™ Herbicide EC 2'Multi-spectra glasses' for scanning electron microscopy 2
... to them. We've heard a lot of chatter about improving ... lost in that clamor is the thought that you need ... can hope to improve it. Apparently, even if you're Britney ... also don't want to confuse the kinds of business relationships ...
... MADISON, Wis. -- What's more important to a manufacturing company: ... Center for Quick Response Manufacturing , ruthlessly cutting down the ... seen as the best way to reduce costs and end ... ,"It's not usually about buying new equipment," Frank Rath, associate ...
... left, and Charletta D. Flowers, right, who work for Milwaukee-based ... for the Energizer Battery Company in St. Louis. On ... Milwaukee (YPM) threw an elaborate party at Milwaukee's ... group had a lot to be proud of. In the ...
Cached Biology Technology:Customers, clients and partners, oh my! 2Customers, clients and partners, oh my! 3University center offers speed boost to manufacturers 2Young Professionals of Milwaukee Celebrates Its Third Birthday, Looks To The Future 2Young Professionals of Milwaukee Celebrates Its Third Birthday, Looks To The Future 3
Chicken polyclonal to QPRT ( Abpromise for all tested applications). Antigen: Synthetic peptide, corresponding to Internal sequence amino acids 123-237 of Human QPRT Entrez Gene ID: 23475 ...
...
Protein Marker Detection Pack contains biotinylate...
...
Biology Products: