Navigation Links
MSU researcher links diabetic complication, nerve damage in bone marrow
Date:1/6/2010

EAST LANSING, Mich. A research team led by a Michigan State University professor has discovered a link between diabetes and bone marrow nerve damage that may help treat one of the disease's most common and potentially blindness-causing complications.

The key to better treating retinopathy damage to blood vessels in the retina that affects up to 80 percent of diabetic patients lies not in the retina but in damage to the nerves found in bone marrow that leads to the abnormal release of stem cells, said Julia Busik, an associate professor in MSU's Department of Physiology.

"With retinopathy, blood vessels grow abnormally in the retina, distort vision and eventually can cause blindness," said Busik, whose research appears in a recent issue of the Journal of Experimental Medicine. "There has been a lot of progress in treating the complication, but most treatments use a laser that is painful to the patient and destroys parts of the retina."

Busik and her team found that nerve damage in diabetic bone marrow where stem cells known as endothelial progenitor cells reside affects the daily release of those EPCs into the bloodstream. Normally EPCs would exit the bone marrow and repair damage done in the vascular system during sleep.

Using animal models, the research team observed that the pattern of EPC release is faulty in diabetic bone marrow, creating abnormally low levels of EPCs during sleep, when they are needed most. That decrease in EPC release from a diabetic patient's bone marrow preceded the development of retinopathy.

"When the bone marrow suffers nerve damage in diabetic patients, it no longer provides a signal for the timely release of these reparative stem cells," Busik said.

This novel finding shows that bone marrow nerve damage represents a new therapeutic target for treatment of all diabetic vascular complications, such as retinopathy.

"This opens up new avenues to better treatments outside of the retina that focus on stem cells and the causes of the nerve damage in bone marrow," said Busik, whose collaborators included other researchers from MSU and the University of Florida. "We know what happens in the retina and have treatments that are very invasive; we now can look at a host of other options."

Those options include looking at ways to prevent the original nerve damage in the bone marrow and potentially repairing or replacing the damaged endothelial progenitor cells.

Busik's work was funded by the National Institutes of Health, the Juvenile Diabetes Research Foundation and the Michigan Agricultural Experiment Station.

Future work needs to be done to explain why the nerve damage in bone marrow occurs in diabetic patients to begin with, she said.


'/>"/>

Contact: Jason Cody
codyja@msu.edu
517-432-0924
Michigan State University
Source:Eurekalert

Related biology news :

1. Researchers pin down long-elusive protein thats essential to life as we know it
2. Researchers use new acoustic tools to study marine mammals and fish
3. Scott & White Healthcare researcher finds success with new anti-cancer drug
4. Scott & White Healthcare researcher finds success with new anti-cancer drug
5. Researchers to investigate the genetics of congenital heart disease
6. Researchers design a tool to induce controlled suicide in human cells
7. Researchers work on vaccine to improve immune system in newborns
8. IUPUI researchers tackle protein mechanisms behind limb regeneration
9. MDC researchers identify a scaffold regulating protein disposal
10. UCLA researchers engineer bacteria to turn carbon dioxide into liquid fuel
11. University of Texas Southwestern Medical Center researcher wins Avanti Award in lipids
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... to expand at a CAGR of 25.76% during the ... is the primary factor for the growth of the ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem ... technology, application, and geography. The stem cell market of ...
(Date:3/30/2017)... March 30, 2017 The research team of ... three-dimensional (3D) fingerprint identification by adopting ground breaking 3D fingerprint minutiae ... realm of speed and accuracy for use in identification, crime investigation, ... cost. ... A research ...
(Date:3/27/2017)... 2017  Catholic Health Services (CHS) has been ... (HIMSS) Analytics for achieving Stage 6 on the ... In addition, CHS previously earned a place in ... electronic medical record (EMR). "HIMSS Analytics ... EMR usage in an outpatient setting.  This recognition ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia Inc ., a ... Webinar titled, “Pathology is going digital. Is your lab ready?” with Dr. Nicolas ... practices and how Proscia improves lab economics and realizes an increase in diagnostic ...
(Date:10/11/2017)... Florida (PRWEB) , ... October 11, 2017 , ... ... Drug Administration (FDA) has granted orphan drug designation to SBT-100, its novel anti-STAT3 ... for the treatment of osteosarcoma. SBT-100 is able to cross the cell membrane ...
(Date:10/10/2017)... International research firm Parks Associates announced today that ... TMA 2017 Annual Meeting , October 11 in Scottsdale, ... security market and how smart safety and security products impact the competitive ... Parks Associates: Smart Home Devices: Main ... "The residential security market has experienced continued ...
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer ... first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , With ... with the challenge of how to continue to feed a growing nation. At the ...
Breaking Biology Technology: