Navigation Links
MSU researcher links diabetic complication, nerve damage in bone marrow
Date:1/6/2010

EAST LANSING, Mich. A research team led by a Michigan State University professor has discovered a link between diabetes and bone marrow nerve damage that may help treat one of the disease's most common and potentially blindness-causing complications.

The key to better treating retinopathy damage to blood vessels in the retina that affects up to 80 percent of diabetic patients lies not in the retina but in damage to the nerves found in bone marrow that leads to the abnormal release of stem cells, said Julia Busik, an associate professor in MSU's Department of Physiology.

"With retinopathy, blood vessels grow abnormally in the retina, distort vision and eventually can cause blindness," said Busik, whose research appears in a recent issue of the Journal of Experimental Medicine. "There has been a lot of progress in treating the complication, but most treatments use a laser that is painful to the patient and destroys parts of the retina."

Busik and her team found that nerve damage in diabetic bone marrow where stem cells known as endothelial progenitor cells reside affects the daily release of those EPCs into the bloodstream. Normally EPCs would exit the bone marrow and repair damage done in the vascular system during sleep.

Using animal models, the research team observed that the pattern of EPC release is faulty in diabetic bone marrow, creating abnormally low levels of EPCs during sleep, when they are needed most. That decrease in EPC release from a diabetic patient's bone marrow preceded the development of retinopathy.

"When the bone marrow suffers nerve damage in diabetic patients, it no longer provides a signal for the timely release of these reparative stem cells," Busik said.

This novel finding shows that bone marrow nerve damage represents a new therapeutic target for treatment of all diabetic vascular complications, such as retinopathy.

"This opens up new avenues to better treatm
'/>"/>

Contact: Jason Cody
codyja@msu.edu
517-432-0924
Michigan State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers pin down long-elusive protein thats essential to life as we know it
2. Researchers use new acoustic tools to study marine mammals and fish
3. Scott & White Healthcare researcher finds success with new anti-cancer drug
4. Scott & White Healthcare researcher finds success with new anti-cancer drug
5. Researchers to investigate the genetics of congenital heart disease
6. Researchers design a tool to induce controlled suicide in human cells
7. Researchers work on vaccine to improve immune system in newborns
8. IUPUI researchers tackle protein mechanisms behind limb regeneration
9. MDC researchers identify a scaffold regulating protein disposal
10. UCLA researchers engineer bacteria to turn carbon dioxide into liquid fuel
11. University of Texas Southwestern Medical Center researcher wins Avanti Award in lipids
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/hhwlfj/huawei_ascend ... "Huawei Ascend Mate 7 Fingerprint Sensor - Reverse ... Huawei,s technological choice for the fingerprint sensor ... and Samsung,s one. The Ascend Mate 7 presents ... a main actor in capacitive sensing human interface ...
(Date:6/23/2015)... Research and Markets( ... "Body-Worn Temperature Sensors Market - Global Industry ... - 2020" report to their offering. ... global body-worn temperature sensors market. The global body-worn ... basis of types, care setting, patient demographic, applications ...
(Date:6/18/2015)... NEW YORK , June 18, 2015 ... in US$ Million by the following Product Segments, which ... Immunoassay Systems, Chemiluminescence Immunoassay Systems, Radio Immunoassay Systems, and ... for the US, Canada , ... Asia-Pacific , Latin America ...
Breaking Biology News(10 mins):Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2Body-Worn Temperature Sensors Market - Global Industry Analysis 2Global Immunoassay Systems Market 2Global Immunoassay Systems Market 3Global Immunoassay Systems Market 4Global Immunoassay Systems Market 5Global Immunoassay Systems Market 6Global Immunoassay Systems Market 7Global Immunoassay Systems Market 8Global Immunoassay Systems Market 9Global Immunoassay Systems Market 10Global Immunoassay Systems Market 11Global Immunoassay Systems Market 12Global Immunoassay Systems Market 13Global Immunoassay Systems Market 14Global Immunoassay Systems Market 15Global Immunoassay Systems Market 16Global Immunoassay Systems Market 17Global Immunoassay Systems Market 18Global Immunoassay Systems Market 19Global Immunoassay Systems Market 20Global Immunoassay Systems Market 21Global Immunoassay Systems Market 22Global Immunoassay Systems Market 23Global Immunoassay Systems Market 24Global Immunoassay Systems Market 25Global Immunoassay Systems Market 26Global Immunoassay Systems Market 27Global Immunoassay Systems Market 28Global Immunoassay Systems Market 29
... bully so your buddy can get some tail may seem ... some lizards, it also gives a fascinating peek into hard-wired ... on earth looking to reproduce, and their strategies have lessons ... the Proceedings of the National Academy of Sciences provides the ...
... been right all along ?a siesta after a hearty lunch ... of Manchester have for the first time uncovered how brain ... after we eat. , The findings ?published in the scientific ... eating disorders as well as understanding levels of consciousness. , ...
... Wisconsin-Madison School of Medicine and Public Health has discovered a ... of blood vessels, or angiogenesis. , The finding may ... the senior author on the study, a professor of pharmacology ... Center. , The research, published in the Journal of ...
Cached Biology News:Nice guys do finish first in lizards' evolutionary race 2Why we could all do with a siesta 2New angiogenesis finding may help fight cancer growth 2New angiogenesis finding may help fight cancer growth 3New angiogenesis finding may help fight cancer growth 4
(Date:6/29/2015)... , June 29, 2015  MiMedx Group, Inc. (NASDAQ: ... human amniotic tissue and patent-protected processes to develop and ... Surgical, Orthopedic, Spine, Sports Medicine, Ophthalmic and Dental sectors ... H. "Pete" Petit, has been awarded the Lifetime Achievement ... Southeast Program. The Entrepreneur Of The ...
(Date:6/29/2015)... , June 29, 2015 According to ... RNA, XNA), by Application (Diagnostics, Therapeutics, R&D), by Technology (SELEX, ... Pharmaceutical Companies, CRO) - Global Forecast to 2020", published by ... Million by 2020 from $107.56 Million in 2015, at a ... ables and 67 F igures spread ...
(Date:6/29/2015)... June 29, 2015   Veracyte, Inc . (Nasdaq: ... field of molecular cytology, today announced that it has ... Top Workplaces list for the second year in a ... solely on an annual survey of Bay Area-company employees. ... the degree to which Veracyte values our employees and ...
(Date:6/29/2015)... 29, 2015 Elsevier , ... products and services, today announced the highlights of its ... 2014 Journal Citation Reports® (JCR) published by Thomson Reuters, ... from 2013 to 2014, ahead of the aggregate across ... rank in 62 subject categories, up from 61 in ...
Breaking Biology Technology:EY Entrepreneur Of The Year Program Recognizes Pete Petit, The Chairman & CEO of MiMedx 2Aptamers Market Worth $244.93 Million by 2020 2Aptamers Market Worth $244.93 Million by 2020 3Aptamers Market Worth $244.93 Million by 2020 4Veracyte Named a 2015 "Top Workplace" in the San Francisco Bay Area 2Veracyte Named a 2015 "Top Workplace" in the San Francisco Bay Area 3Elsevier Announces 2014 Citation Impact Highlights 2Elsevier Announces 2014 Citation Impact Highlights 3
... chips, open-source OS , ,Chippewa Falls, Wis.This is crunch ... than one. , ,As the companys sprawling manufacturing plant here ... final days of its fiscal first quarter, it is hoping ... Altix 3000 family of servers and superclusters, can carry it ...
... We recently had the opportunity to discuss ... more efficient information technology based services - internally and ... to help entrepreneurs with investment funding and health insurance. ... faces as it attempts to limit unsolicited e-mail. ...
... you receive an e-mail from Microsoft and it even looks ... Be Careful! These e-mails appear to be the result ... shares. It is a Mass-Mailing worm which disables processes related ... , ,According to Microsoft, the worm typically spoofs ...
Cached Biology Technology:SGI banking on Altix to pay the freight 2SGI banking on Altix to pay the freight 3WTN Interview with Governor Doyle 2WTN Interview with Governor Doyle 3WTN Interview with Governor Doyle 4WTN Interview with Governor Doyle 5WTN Interview with Governor Doyle 6Fake Microsoft E-Mails Are WORMS in Disguise 2
... number is a new product ... Cornings product number. If showing ... under the old Sigma-Aldrich number ... for assistance. Mfr Desig: ...
... Virgin, optically clear polystyrene with frosted ... coordinates for cell counting. 100% integrity ... a new product number, created to ... showing no availability yet, please order ...
... LIC Duet™ T7•Tag ® Ek Adaptor ... operator, ribosome binding site (rbs), ATG translation ... sequence. The T7•Tag is a small epitope ... detection of the target protein with T7•Tag ...
The LIC Duet™ Mini Adaptor encodes a T7 promoter, lac operator, ribosome binding site (rbs), and an ATG translation initation codon. This adaptor is designed for expression of a target protei...
Biology Products: