Navigation Links
MSU researcher links diabetic complication, nerve damage in bone marrow
Date:1/6/2010

EAST LANSING, Mich. A research team led by a Michigan State University professor has discovered a link between diabetes and bone marrow nerve damage that may help treat one of the disease's most common and potentially blindness-causing complications.

The key to better treating retinopathy damage to blood vessels in the retina that affects up to 80 percent of diabetic patients lies not in the retina but in damage to the nerves found in bone marrow that leads to the abnormal release of stem cells, said Julia Busik, an associate professor in MSU's Department of Physiology.

"With retinopathy, blood vessels grow abnormally in the retina, distort vision and eventually can cause blindness," said Busik, whose research appears in a recent issue of the Journal of Experimental Medicine. "There has been a lot of progress in treating the complication, but most treatments use a laser that is painful to the patient and destroys parts of the retina."

Busik and her team found that nerve damage in diabetic bone marrow where stem cells known as endothelial progenitor cells reside affects the daily release of those EPCs into the bloodstream. Normally EPCs would exit the bone marrow and repair damage done in the vascular system during sleep.

Using animal models, the research team observed that the pattern of EPC release is faulty in diabetic bone marrow, creating abnormally low levels of EPCs during sleep, when they are needed most. That decrease in EPC release from a diabetic patient's bone marrow preceded the development of retinopathy.

"When the bone marrow suffers nerve damage in diabetic patients, it no longer provides a signal for the timely release of these reparative stem cells," Busik said.

This novel finding shows that bone marrow nerve damage represents a new therapeutic target for treatment of all diabetic vascular complications, such as retinopathy.

"This opens up new avenues to better treatm
'/>"/>

Contact: Jason Cody
codyja@msu.edu
517-432-0924
Michigan State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers pin down long-elusive protein thats essential to life as we know it
2. Researchers use new acoustic tools to study marine mammals and fish
3. Scott & White Healthcare researcher finds success with new anti-cancer drug
4. Scott & White Healthcare researcher finds success with new anti-cancer drug
5. Researchers to investigate the genetics of congenital heart disease
6. Researchers design a tool to induce controlled suicide in human cells
7. Researchers work on vaccine to improve immune system in newborns
8. IUPUI researchers tackle protein mechanisms behind limb regeneration
9. MDC researchers identify a scaffold regulating protein disposal
10. UCLA researchers engineer bacteria to turn carbon dioxide into liquid fuel
11. University of Texas Southwestern Medical Center researcher wins Avanti Award in lipids
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/11/2015)... 11, 2015 Curemark LLC, a privately held ... a new Phase III double blind, randomized, placebo-controlled clinical ... CM-AT, on all children ages 3-8 with Autism. Previously, ... III double blinded clinical trial for CM-AT in children ... the digestive enzyme chymotrypsin. This new trial will help ...
(Date:5/5/2015)... , May 5, 2015, NXT-ID, Inc. (NASDAQ: ... focused on the growing mobile commerce market, reminds investors and ... Technology Officer, is presenting  at CARTES SECURE CONNEXIONS AMERICA 2015, ... 2015. The three-day conference is organized into ... speaking in is themed Global Fraud: Where is the ...
(Date:4/20/2015)... , April 20, 2015 Huntington Memorial Hospital ... to implant a new miniaturized, wireless monitoring sensor to ... the first and only FDA-approved heart failure monitoring device ... when used by physicians to manage heart failure. ... is implanted in the pulmonary artery (PA) during a ...
Breaking Biology News(10 mins):Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3
... A University of California, Davis, microbiologist and a professional ... microbes to the International Space Station and study their ... Nov. 29 as winners of the International Space Station ... The team is led by Professor Jonathan Eisen ...
... 7. Dezember 2012 /PRNewswire/ -- Integrated Biometrics, LLC ... neuesten Fingerabdrucktechnologie einen weiteren technologischen Durchbruch bekannt. ... Produkt unter Verwendung der LES-Technologie (Light Emitting ... Film Transistor, TFT) her. Die LES-Technologie verwendet ...
... new plant-parasitic nematode worm ( Meloidoderita salina ) ... Michel Bay (MSMB) in France, where its abbey is a ... soil and is derived from the Latin word ,sal, or ... open source scientific journal ZooKeys . ...
Cached Biology News:Cheering microbes into space 2Integrated Biometrics stellt Sherlock vor - die weltweit leichtesten, dünnsten und kleinsten Appendix F Mobile ID-Fingerabdrucksensoren 2A pattern given by nature 2
(Date:5/21/2015)... 21, 2015  CytRx Corporation (NASDAQ: CYTR ... in oncology, today announced positive updated results from ... for the treatment of unresectable glioblastoma multiforme (GBM), ... multisite trial is designed to investigate the preliminary ... tumors have progressed following prior treatment with surgery, ...
(Date:5/21/2015)... Prussia, PA (PRWEB) May 21, 2015 ... O’Neill has joined the firm as senior statistician and ... 30 years of experience in the management and analysis ... biologics, pharmaceutical and chemical industries. , “We’re delighted to ... longstanding capabilities in data analytics,” said Dr. Philippe Cini, ...
(Date:5/20/2015)... 2015  Select Medical Corporation ("Select") (NYSE: ... granted early termination of the waiting period under ... as amended, applicable to the acquisition of Concentra ... venture that Select has created with Welsh, Carson, ... announced, MJ Acquisition Corporation has signed a definitive ...
(Date:5/20/2015)... May 20, 2015  Haemonetics Corporation (NYSE: HAE ... & CEO, will present at The Jefferies 2015 Global ... on June 1 st , 2015 at 8:30am Eastern ... Concannon,s presentation live via webcast at: http://wsw.com/webcast/jeff88/hae ... HAE ) is a global healthcare company dedicated ...
Breaking Biology Technology:CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 2CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 3CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 4CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 5CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 6CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 7Julia O’Neill Joins Tunnell Consulting’s Operational and Process Improvement Practice 2Select Medical Corporation's Proposed Acquisition of Concentra Inc. through Joint Venture with Welsh Carson Receives Antitrust Clearance 2
... Nanotechnologies, Inc. ("Shrink") (OTC Markets: INKN), an innovative high ... binding letter of intent to acquire 100% of Hawaii-based ... with global distribution for its award-winning suites of life ... Shrink will exchange 25,750,000 shares of ...
... 11, 2011 Dyadic International, Inc. ("Dyadic") (OTC ... the discovery, development, manufacture and sale of enzyme ... and biopharmaceutical industries, today announced that its President ... at the Advanced Biofuels Leadership Conference taking place ...
... advancements of our electronic age rests on our ability ... to point B, through circuitry. Doing so requires particular ... solar cells, and that task falls to semiconductors. ... schools of Engineering and Applied Science and Arts and ...
Cached Biology Technology:Shrink Nanotechnologies Signs Binding Letter of Intent to Acquire 100% of Hawaii-Based Nanopoint, Inc. 2Shrink Nanotechnologies Signs Binding Letter of Intent to Acquire 100% of Hawaii-Based Nanopoint, Inc. 3Shrink Nanotechnologies Signs Binding Letter of Intent to Acquire 100% of Hawaii-Based Nanopoint, Inc. 4Dyadic International to Present at Advanced Biofuels Leadership Conference 2Penn research advances understanding of lead selenide nanowires 2Penn research advances understanding of lead selenide nanowires 3
... Affinity Life Sciences can provide custom microplate coating using ... washes a variety of plate formats. We can also accommodate ... volume range of 0.5-320 L):, , ... 96 well microplate, ...
...
... the first biological reagent that ... and not just by inhibiting ... anti-mycoplasma agent that can be ... directly. The cytotoxicity of Mynox ...
Mynox is intended for research use only. Mynox is used for the elimination of Mycoplasma and Acholeplasma in cell and virus cultures, and other biologicals....
Biology Products: