Navigation Links
MSU researcher awarded $2 million to tackle parasitic tropical diseases
Date:2/4/2010

EAST LANSING, Mich. In an effort to eliminate the tropical diseases elephantiasis and river blindness, a Michigan State University researcher has been awarded $2 million to reformulate an existing drug that could stop the debilitating diseases in their tracks.

Charles Mackenzie, a professor of veterinary pathology in the College of Veterinary Medicine, was awarded the funding via a larger $13 million grant the Washington University School of Medicine in St. Louis received from the Bill & Melinda Gates Foundation.

Elephantiasis (lymphatic filariasis) and river blindness (onchocerciasis) known as filarial diseases, in which the body is infected with parasitic worms afflict about 140 million people worldwide, doing much of its damage in equatorial Africa.

Elephantiasis, caused by tiny worms spread via mosquitoes, results in severe swelling of the legs, arms and torso. River blindness is spread by black flies, and after the parasitic worms die in a person's eye, can cause blindness and debilitating skin disease.

Mackenzie, who has been studying filarial diseases for more than 30 years and has done extensive work in Tanzania and Ecuador, is focusing on flubendazole. The drug was used in the 1980s with good results against filarial worms when it was injected in animals and humans. However, the injections caused severe abscesses and lost effectiveness outside of the digestive system.

"We think the oil the drug was dissolved in before administering it may have caused the reactions," Mackenzie said. "We are working now to develop a new way to safely administer this medicine."

Since the medicine targets the adult parasitic worms so well, Mackenzie is confident that developing a safe way to deliver it would have a huge impact.

"The technology we have today is leaps and bounds ahead of what we were using in the 1980s," he said. "If we can reformulate the drug and easily administer it, we can make meeting t
'/>"/>

Contact: Jason Cody
codyja@msu.edu
517-432-0924
Michigan State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Secrets to superb malting barleys explored by ARS researchers
2. UF researchers: Ancient crocodile relative likely food source for Titanoboa
3. ARS researchers develop method to speed up breeding of scab-resistant barley cultivars
4. Ability to navigate may be linked to genes, researcher says
5. MSU researcher identifies cell mechanism leading to diabetic blindness
6. Boston University School of Medicine researcher awarded the 2010 Avanti Award in Lipids
7. National Jewish Health researchers discover how virulent bacteria
8. Epigenetics could help researchers determine any risks associated with low-dose radiation
9. University of the Basque Country researchers decode transcriptome for gray mullet
10. Researchers correct the record about behavior of important human protein tied to cancer
11. Bat researchers no longer flying blind on echolocation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... engineering at the University of Houston, has written ... organ development., "Introduction to Tissue Engineering: Applications and ... the field of artificial organ development. Metin Akay, ... UH, served as a series editor on the ... published books on the subject of growing artificial ...
(Date:7/25/2014)... of Adelaide has opened the way for the development of ... In Australia, annual barley production is second only to wheat ... of the most important diseases of barley. , Senior Research ... of special growths on the cell walls of barley plants ... , The research, by the ARC Centre of Excellence in ...
(Date:7/25/2014)... a complex congenital central nervous system disease that ... neural tubes during the embryonic phase. Many patients ... incontinence and neurocognitive retardation. Such problems decrease the ... Researchers at Ankara Physical Medicine and Rehabilitation Education ... in children with SB, using the Pediatric Evaluation ...
Breaking Biology News(10 mins):University of Houston researcher publishes textbook on tissue engineering 2New hope for powdery mildew resistant barley 2
... formation of the centromere, a key cellular structure in powering ... earned him a paper in Nature Cell Biology ... year, for a maximum of five years. Lars Jansen ... in Portugal, last year to head the Epigenetic Mechanisms group. ...
... repairing DNA strands damaged by oxidation leads to several ... contributes to the development of cancer. That,s the conclusion ... by researchers at the National Institute of Standards and ... the New York University School of Medicine (NYUSM). ...
... CHICAGO The American Dietetic Association has released an ... diets, if well-planned, are healthful and nutritious for adults, ... treat chronic diseases including heart disease, cancer, obesity and ... of the Journal of the American Dietetic Association ...
Cached Biology News:Double success for Instituto Gulbenkian de Ciencia scientists working on chromosome segregation 2Genetically engineered mice yield clues to 'knocking out' cancer 2ADA releases updated position paper on vegetarian diets 2
(Date:7/24/2014)... RIDGE, Tenn., July 24, 2014 -- A novel combination ... the Department of Energy,s Oak Ridge National Laboratory an ... for its unusual physical and electrochemical properties. , ... how oxygen affects the surface of a perovskite manganite, ... behavior. The new avenue to understand surface behavior could ...
(Date:7/24/2014)... sophisticated equipment, trained personnel, and detection dogs to ... attacks. A revolutionary new electronic chip with nano-sized ... much easier. , The groundbreaking nanotechnology-inspired sensor, devised ... ,s School of Chemistry and Center for Nanoscience ... Tracense, picks up the scent of explosives molecules ...
(Date:7/24/2014)... Research and Markets has announced ... 2014-2018" report to their offering.  ... the in vitro growth of plant or animal cells ... biopharmaceutical production. Cell culture is a crucial step in ... cell culture consumables are necessary for the in vitro ...
(Date:7/24/2014)... San Francisco, CA (PRWEB) July 24, 2014 ... Wednesday to be semi-finalists in Livestrong’s Big C Competition. ... Decisive Health are each headed to the semi-final round. ... in Livestrong’s exclusive three-month accelerator program, complete with mentoring ... country. , As part of the angelMD commitment ...
Breaking Biology Technology:ORNL study reveals new characteristics of complex oxide surfaces 2Nano-sized chip 'sniffs out' explosives far better than trained dogs 2Global Cell Culture Market 2014-2018: Key Vendors are Becton, Dickinson and Co, EMD, GE Healthcare, Lonza Group, Sigma Aldrich and Thermo Fisher Scientific 23 angelMD Startups Make Livestrong Big C Semi-finals 2
... ) today announced that Dan Maher , Senior Vice President of Product Development of BioMarin, will present a company update at the Barclays Capital Global Healthcare Conference in ... ... ... ...
... ... pressure switches and pressure transmitters moves to Hatfield, Pa. , ... Hatfield, PA (Vocus) March 17, 2010 -- ... a new production line for the recently acquired pressure gauge product family at its ...
... ... generation business intelligence software, today announced the availability of Centrifuge 1.8, the latest version ... ... Centrifuge Systems, Inc. , a leading provider of next generation business intelligence software, ...
Cached Biology Technology:BioMarin to Present at the Barclays Capital Global Healthcare Conference 2BioMarin to Present at the Barclays Capital Global Healthcare Conference 3Brooks Instrument Opens Pressure Gauge Production Line 2Brooks Instrument Opens Pressure Gauge Production Line 3Centrifuge Releases New Data Visualization Software 2Centrifuge Releases New Data Visualization Software 3