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MSU research may lead to new ways to control honeybee parasite
Date:12/9/2009

EAST LANSING, Mich. Ground-breaking discoveries by Michigan State University researchers could help protect honeybees from deadly parasites that have devastated commercial colonies.

The MSU researchers for the first time were able to produce in the laboratory proteins that help channel sodium ions through cell membranes of parasites known as Varroa mites. The research, using cellular frog eggs, also found that these proteins react to chemicals differently than the sodium channel proteins in honeybees, a finding that could be a key to controlling the mites.

"The insecticide used to control Varroa mites, fluvalinate, targets the mite sodium channel," said Ke Dong, MSU professor of entomology. "But the mites are becoming resistant to fluvalinate. Successfully producing the mite sodium channel in the lab now allows scientists to develop new chemicals that target the mite sodium channel but don't affect the honeybee's."

Fluvalinate paralyzes the mite and eventually kills it. But in addition to the problem of growing mite resistance, the pesticide can harm bees and contaminate honey if not used extremely carefully.

The MSU scientists also found two amino acids in the mite sodium channel that make the mite resistant to tetrodotoxin, or TTX, a deadly poison found in pufferfish not currently used as an insecticide

"Chemicals such as fluvalinate and TTX target sodium channels in insects and mites, so this basic research opens the door for more applied research on chemicals to control mites and other pest insects," Dong said.

Other members of the MSU team are Yuzhe Du, senior research associate; Yoshiko Nomura, visiting scholar; Zhiqi Liu, former research associate; and Zachary Huang, associate professor, all in the Department of Entomology.

Varroa mites invaded the United States from the eastern hemisphere in 1987 and can kill an entire honeybee colony within a year, feeding on bee blood and transmitting
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Contact: Jamie DePolo
depolo@msu.edu
609-354-8403
Michigan State University
Source:Eurekalert  

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