Navigation Links
MSU project may lead to new approaches against lung cancer

EAST LANSING, Mich. A Michigan State University researcher is analyzing the immune system's own ability to protect the body against lung cancer.

The results of the work by Alison Bauer, an assistant professor of pathobiology and diagnostic investigation in the College of Veterinary Medicine, are expected to provide new approaches to prevent, identify and treat lung cancer.

The research is funded by a $720,000 grant from the American Cancer Society.

"Chronic inflammatory lung diseases, such as asthma and chronic obstructive pulmonary disease, are risk factors in the development of lung cancer," Bauer explained. "However, activation of certain components of the immune system namely the part of our immune system that responds first to an injury, or the innate immune system may provide protection against lung cancer development."

Bauer explains her research entitled "The role of toll-like receptor 4 in mouse pulmonary neoplasia" as follows: Previous research has determined that farm and textile workers exposed to elevated levels of a bacterial component called endotoxin are at a reduced risk of developing lung cancer.

After being introduced to the body, endotoxin binds to a specific protein on cells known as "toll-like" receptors; these receptors are involved in innate immunity. The primary receptor binding endotoxin is called toll-like receptor 4 (TLR4).

Bauer and her team have previously shown that TLR4 acts in a protective manner against the development of chronic lung inflammation and lung cancer in mice; that research was published last year in the journal Molecular Cancer. With this grant, they will further investigate how and why TLR4 acts in a protective manner, focusing on the cells involved in the inflammation process in mice models.

Bauer also will look at intercellular communication, which is one way neighboring cells can communicate, and growth factor regulation. The team will investigate the role of these pathways in the protection observed through TLR4, which in other cancers is required for some chemotherapeutic drugs to be effective.


Contact: Jason Cody
Michigan State University

Related biology news :

1. Case Western Reserve University project ties soil conservation and river management together
2. Human Microbiome Project awards funds for technology development, data analysis and ethical research
3. Academy participates in project to discover drugs, biofuels in tropical seas
4. Field-hospital-on-a-chip project awarded to nanoengineer from UC San Diego
5. State fund advances titanium powder research, 9 other Iowa State projects
6. TECNALIA leads five projects within the VII Framework Program
7. Natural Capital Project to develop conservation software
8. Bangladesh Voter Registration Project Now Using MegaMatcher Biometric Technology to Detect and Prevent Duplicate Registrations
9. VUANCE Announces Crime Scene Security and Evidentiary Tracking Development Project
10. Human connection to our nations fisheries comes alive through oral history project
11. A BBVA Foundation project comes up with a system enabling detection of cetacean hearing loss
Post Your Comments:
(Date:10/29/2015)... 2015 Today, LifeBEAM , a ... 2XU, a global leader in technical performance sports ... with advanced bio-sensing technology. The hat will allow ... key biometrics to improve overall training performance. As ... will bring together the most advanced technology, extensive ...
(Date:10/26/2015)... , October 26, 2015 ... --> adds Biometrics Market ... 2021 as well as Emerging Biometrics ... reports to its collection of IT ... . --> ...
(Date:10/23/2015)... GOLETA, California , October 23, 2015 ... and SensoMotoric Instruments (SMI) announce a mobile plug and ... captured during interactive real-world tasks SensoMotoric Instruments ... of their established wearable solutions for eye tracking and ... behavior captured with SMI Eye Tracking Glasses 2w ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... LEXINGTON, Massachusetts , November 24, 2015 ... Officer, will participate in the Piper Jaffray 27 th Annual ... on Tuesday, December 1, 2015, at 8:30 a.m. EST (1:30 p.m. ... Poulton , Chief Financial Officer, will participate in the Piper Jaffray ... City , NY on Tuesday, December 1, 2015, at 8:30 ...
(Date:11/24/2015)... AVIV, Israel , Nov. 24, 2015  Tikcro Technologies Ltd. (OTCQB: ... held on December 29, 2015 at 11:00 a.m. Israel ... Co., Electra Tower, 98 Yigal Allon Street, 36 th Floor, ... election of Eric Paneth and Izhak Tamir to ... and Rami Skaliter as external directors; , approval of an amendment ...
(Date:11/24/2015)... Nov. 24, 2015  Twist Bioscience, a company ... Leproust, Ph.D., Twist Bioscience chief executive officer, will ... on December 1, 2015 at 3:10 p.m. Eastern ... City. --> --> ... Twist Bioscience is on Twitter. Sign up to ...
(Date:11/24/2015)... Schlieren, Switzerland (PRWEB) , ... November 24, 2015 , ... ... more organotypic 3D cell culture models, has promoted Melanie Aregger to serve as Chief ... Manager, Ms. Aregger served on the management team and was promoted to ...
Breaking Biology Technology: