Navigation Links
MSU project may lead to new approaches against lung cancer
Date:8/17/2010

EAST LANSING, Mich. A Michigan State University researcher is analyzing the immune system's own ability to protect the body against lung cancer.

The results of the work by Alison Bauer, an assistant professor of pathobiology and diagnostic investigation in the College of Veterinary Medicine, are expected to provide new approaches to prevent, identify and treat lung cancer.

The research is funded by a $720,000 grant from the American Cancer Society.

"Chronic inflammatory lung diseases, such as asthma and chronic obstructive pulmonary disease, are risk factors in the development of lung cancer," Bauer explained. "However, activation of certain components of the immune system namely the part of our immune system that responds first to an injury, or the innate immune system may provide protection against lung cancer development."

Bauer explains her research entitled "The role of toll-like receptor 4 in mouse pulmonary neoplasia" as follows: Previous research has determined that farm and textile workers exposed to elevated levels of a bacterial component called endotoxin are at a reduced risk of developing lung cancer.

After being introduced to the body, endotoxin binds to a specific protein on cells known as "toll-like" receptors; these receptors are involved in innate immunity. The primary receptor binding endotoxin is called toll-like receptor 4 (TLR4).

Bauer and her team have previously shown that TLR4 acts in a protective manner against the development of chronic lung inflammation and lung cancer in mice; that research was published last year in the journal Molecular Cancer. With this grant, they will further investigate how and why TLR4 acts in a protective manner, focusing on the cells involved in the inflammation process in mice models.

Bauer also will look at intercellular communication, which is one way neighboring cells can communicate, and growth factor regulation. The team will investigate the role of these pathways in the protection observed through TLR4, which in other cancers is required for some chemotherapeutic drugs to be effective.


'/>"/>

Contact: Jason Cody
codyja@msu.edu
517-432-0924
Michigan State University
Source:Eurekalert

Related biology news :

1. Case Western Reserve University project ties soil conservation and river management together
2. Human Microbiome Project awards funds for technology development, data analysis and ethical research
3. Academy participates in project to discover drugs, biofuels in tropical seas
4. Field-hospital-on-a-chip project awarded to nanoengineer from UC San Diego
5. State fund advances titanium powder research, 9 other Iowa State projects
6. TECNALIA leads five projects within the VII Framework Program
7. Natural Capital Project to develop conservation software
8. Bangladesh Voter Registration Project Now Using MegaMatcher Biometric Technology to Detect and Prevent Duplicate Registrations
9. VUANCE Announces Crime Scene Security and Evidentiary Tracking Development Project
10. Human connection to our nations fisheries comes alive through oral history project
11. A BBVA Foundation project comes up with a system enabling detection of cetacean hearing loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... LOS ANGELES , March 30, 2017  On ... Hack the Genome hackathon at ... This exciting two-day competition will focus on developing health ... experience. Hack the Genome is ... has been tremendous. The world,s largest companies in the ...
(Date:3/28/2017)... 28, 2017 The report "Video ... Monitors, Servers, Storage Devices), Software (Video Analytics, VMS), and ... Global Forecast to 2022", published by MarketsandMarkets, the market ... is projected to reach USD 75.64 Billion by 2022, ... The base year considered for the study is 2016 ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based and ... 2022", published by MarketsandMarkets, the market is expected to be worth USD 18.98 ... Continue Reading ... ...      ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... , ... August 16, 2017 , ... ... microbe delivery system, announced it has secured $2M in funding from an impressive ... Angels, Carmen Innovations, and SVG Thrive Fund. With this investment, 3Bar is broadening ...
(Date:8/15/2017)... ... ... Kapstone Medical is proud to announce that it has reached ... inventors develop and safeguard their latest innovations. The company has grown from a ... clients in the United States and around the world. , Company Founder and ...
(Date:8/15/2017)... NY (PRWEB) , ... August 15, 2017 , ... ... first time on Immuno-Oncology 360° (IO360°) programming through a series of upcoming panels and ... held February 7-9, 2018, at The Roosevelt Hotel in New York City. , “With ...
(Date:8/14/2017)... ... August 14, 2017 , ... The Conference Forum has confirmed the ... place on September 6, 2017 at the Marriott Copley Place in Boston, MA. , ... Informatics, and Regulatory Strategy, Pfizer Innovative Research Lab, Pfizer, who leads 19 industry speakers ...
Breaking Biology Technology: