Navigation Links
MSU project may lead to new approaches against lung cancer
Date:8/17/2010

EAST LANSING, Mich. A Michigan State University researcher is analyzing the immune system's own ability to protect the body against lung cancer.

The results of the work by Alison Bauer, an assistant professor of pathobiology and diagnostic investigation in the College of Veterinary Medicine, are expected to provide new approaches to prevent, identify and treat lung cancer.

The research is funded by a $720,000 grant from the American Cancer Society.

"Chronic inflammatory lung diseases, such as asthma and chronic obstructive pulmonary disease, are risk factors in the development of lung cancer," Bauer explained. "However, activation of certain components of the immune system namely the part of our immune system that responds first to an injury, or the innate immune system may provide protection against lung cancer development."

Bauer explains her research entitled "The role of toll-like receptor 4 in mouse pulmonary neoplasia" as follows: Previous research has determined that farm and textile workers exposed to elevated levels of a bacterial component called endotoxin are at a reduced risk of developing lung cancer.

After being introduced to the body, endotoxin binds to a specific protein on cells known as "toll-like" receptors; these receptors are involved in innate immunity. The primary receptor binding endotoxin is called toll-like receptor 4 (TLR4).

Bauer and her team have previously shown that TLR4 acts in a protective manner against the development of chronic lung inflammation and lung cancer in mice; that research was published last year in the journal Molecular Cancer. With this grant, they will further investigate how and why TLR4 acts in a protective manner, focusing on the cells involved in the inflammation process in mice models.

Bauer also will look at intercellular communication, which is one way neighboring cells can communicate, and growth factor regulation. The team will investigate the role of these pathways in the protection observed through TLR4, which in other cancers is required for some chemotherapeutic drugs to be effective.


'/>"/>

Contact: Jason Cody
codyja@msu.edu
517-432-0924
Michigan State University
Source:Eurekalert

Related biology news :

1. Case Western Reserve University project ties soil conservation and river management together
2. Human Microbiome Project awards funds for technology development, data analysis and ethical research
3. Academy participates in project to discover drugs, biofuels in tropical seas
4. Field-hospital-on-a-chip project awarded to nanoengineer from UC San Diego
5. State fund advances titanium powder research, 9 other Iowa State projects
6. TECNALIA leads five projects within the VII Framework Program
7. Natural Capital Project to develop conservation software
8. Bangladesh Voter Registration Project Now Using MegaMatcher Biometric Technology to Detect and Prevent Duplicate Registrations
9. VUANCE Announces Crime Scene Security and Evidentiary Tracking Development Project
10. Human connection to our nations fisheries comes alive through oral history project
11. A BBVA Foundation project comes up with a system enabling detection of cetacean hearing loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 /PRNewswire/ ... product subsidiary of Infosys (NYSE: INFY ), and ... global partnership that will provide end customers with ... banking and payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ... area for financial services, but it also plays a fundamental ...
(Date:4/26/2016)... 27, 2016 Research and ... Biometrics Market 2016-2020"  report to their offering.  , ... The analysts forecast the global multimodal biometrics ... during the period 2016-2020.  Multimodal biometrics ... such as the healthcare, BFSI, transportation, automotive, and ...
(Date:4/15/2016)... Research and Markets has announced ... 2016-2020,"  report to their offering.  , ... global gait biometrics market is expected to grow ... 2016-2020. Gait analysis generates multiple variables ... to compute factors that are not or cannot ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... - BIOREM Inc. (TSX-V: BRM) ("Biorem" or "the Company") announces ... Clean Technology Fund I, LP and Clean Technology Fund ... venture capital funds which together hold approximately 59% of ... as converted basis), that they have entered into an ... in Biorem to TUS Holdings Co. Ltd. ("TUS") (en.tusholdings.com) ...
(Date:6/27/2016)... N.C. (PRWEB) , ... June 27, 2016 , ... ... commercial operations for Amgen, will join the faculty of the University of ... as adjunct professor of strategy and entrepreneurship at UNC Kenan-Flagler, with a focus ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and ... and the 6000i models are higher end machines that use the more unconventional z-dimension ... light beam from the bottom of the cuvette holder. , FireflySci has developed ...
(Date:6/23/2016)... 23, 2016 /PRNewswire/ - FACIT has announced the ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or ... of a portfolio of first-in-class WDR5 inhibitors for ... as WDR5 represent an exciting class of therapies, ... medicine for cancer patients. Substantial advances have been ...
Breaking Biology Technology: