Navigation Links
MS drug shows promise for preventing heart failure
Date:7/16/2013

A drug already approved to treat multiple sclerosis may also hold promise for treating cardiac hypertrophy, or thickening of the cardiac muscle--a disorder that often leads to heart failure, researchers at the University of Illinois at Chicago College of Medicine report.

The findings are published in the July 16 issue of Circulation: Heart Failure.

Cardiac hypertrophy is a slow thickening of the heart muscle that shrinks the interior volume of the heart, forcing the organ to work harder to pump a diminishing volume of blood.

"There comes a day when the heart just can't keep up any more, and it fails," says R. John Solaro, UIC distinguished university professor and head of physiology and biophysics.

Cardiac hypertrophy, which afflicts one in 500 people, can be caused by high blood pressure or inherited through genes that control contraction of the heart.

Solaro and his colleagues believe that if the thickening of the heart muscle could be slowed, or maybe even reversed, heart failure could be prevented.

Solaro and his UIC colleague Yunbo Ke, research assistant professor of physiology and biophysics, were interested in a chemical derived from a fungus used in traditional Chinese medicine as an eternal-youth nostrum. That compound, designated FTY-720, has been developed into a drug to treat multiple sclerosis and is a chemical cousin to the drug most widely used to suppress the immune system and prevent organ rejection in transplant patients.

The substance, Solaro said, "mimics certain lipids in the body that play a role in the development of cardiac hypertrophy."

Using an experimental mouse model of cardiac hypertrophy, Solaro and his team found that FTY-720 significantly reduced heart mass; lessened fibrosis, or stiffening of the heart muscle; and improved overall cardiac function in the mice that received the drug.

The researchers also showed that the drug inhibits expressi
'/>"/>

Contact: Sharon Parmet
sparmet@uic.edu
312-413-2695
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genetic survey of endangered Antarctic blue whales shows surprising diversity
2. University of Houston study shows BP oil spill hurt marshes, but recovery possible
3. Weakness can be an advantage in surviving deadly parasites, a new study shows
4. Study shows unified process of evolution in bacteria and sexual eukaryotes
5. Sexual reproduction brings long-term benefits, study shows
6. UCSB study shows forest insects and diseases arrive in US via imported plants
7. Study shows botanical formula fights prostate cancer
8. Transcatheter aortic valve implantation shows promise in patients with severe aortic stenosis
9. Buy coal? New analysis shows purchasing fossil fuel deposits best way to fight climate change
10. Global Surgical Devices Market Growth Driven by Improving Standards of Living and Longer Life Expectancies, Research Shows
11. CU research shows warming climate threatens ecology at mountain research site west of Boulder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... NEW YORK , June 30, 2015 To ... biometric security provider HYPR Corp. announced today the addition of ... will serve as board advisor and David Raviv ... to the team underscore HYPR Corp.,s commitment to providing the ... , Dimitri Sirota co-founded Layer 7 Technologies, a ...
(Date:6/25/2015)... 25, 2015 According to ... (Swipe & Area), Technology, Material (Optical Prism, Piezoelectric, ... Security & Others) & Geography - Global Forecast ... said market is expected to reach $14,500.07 Million ... Browse 76 market Tables and 109 ...
(Date:6/24/2015)... 24, 2015 This report provides market analysis ... six years. It contains an analysis of the drivers, ... their impact from the short, medium, and long term ... industry, market, and technology trends that currently, prevail in ... concerned authorities to efficiently manage the increasing marine traffic ...
Breaking Biology News(10 mins):HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 2HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2
... of banded mongooses in Uganda has shown even small-brained ... how complex human culture could have evolved. Scientists ... five groups of banded mongooses, one of them made ... Mongoose Mob. Their pioneering research observed the animals passing ...
... Wurtz, PhD, a pioneer and leader in the field of ... The Peter and Patricia Gruber Foundation. His discoveries of how ... the groundwork for subsequent research into the neurophysiology of visual ... of how the brain is organized to produce behavior. ...
... harbour seal sets off in pursuit of a fish diner, ... its whiskers. Detecting hydrodynamic trails in water with their sensitive ... turbid conditions. Wolf Hanke from the University of Rostock, Germany, ... distance of 40m before the wake peters out. However, the ...
Cached Biology News:Mongoose traditions shed light on evolution of human culture 2Neuroscientist Robert H. Wurtz receives the $500,000 Gruber neuroscience prize 2Neuroscientist Robert H. Wurtz receives the $500,000 Gruber neuroscience prize 3Harbor seals' whiskers as good at detecting fish as echolocating dolphins 2
(Date:7/29/2015)... , July 29, 2015  Pfenex Inc. (NYSE MKT: ... results will be released on Thursday, August 13, 2015, ... Time, Pfenex management will host a conference call to ... A press release outlining the financial results and business ... Please call 1-866-376-8058 (US) or 1-412-542-4131 (international) ...
(Date:7/29/2015)... ... 29, 2015 , ... The third Medical Innovation Impact Index (MI3) Alert considers ... drug/device combinations. The current system received a score of 0 (range -10 to +10) ... (iPCI) of Fairleigh Dickinson University’s ( FDU ) Rothman Institute of Innovation and ...
(Date:7/29/2015)... /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ: AEZS ) ... optimized Erk inhibitor molecule for development, thus achieving ... new class of potential cancer therapies. ... for therapeutic intervention in cancer. Recently approved compounds ... B-Raf and Mek inhibitors. Erk inhibitors may be ...
(Date:7/29/2015)... ... July 29, 2015 , ... CSSi LifeSciences™ formalized ... specializing in Clinical Trial Management. CSSi LifeSciences is specialized in strategic, marketing, and ... PRC Clinical is focused on Clinical Trial Management, Clinical Site Monitoring, and Clinical ...
Breaking Biology Technology:Pfenex To Report Second Quarter 2015 Results and Provide Business Update on Thursday, August 13, 2015 2Third Medical Innovation Impact Index Issued by Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) 2Third Medical Innovation Impact Index Issued by Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) 3Aeterna Zentaris Announces Optimized Erk Inhibitor Compounds For Further Development 2Aeterna Zentaris Announces Optimized Erk Inhibitor Compounds For Further Development 3CSSi LifeSciences And PRC Clinical Join Forces To Offer Extended Clinical Trial Services 2CSSi LifeSciences And PRC Clinical Join Forces To Offer Extended Clinical Trial Services 3
... DRRX ) announced today financial results for the three ... for the three months,ended September 30, 2008, compared to ... for the three months ended September 30, 2008 was ... for the same period in,2007., (Logo: http://www.newscom.com/cgi-bin/prnh/20020717/DRRXLOGO ...
... /PRNewswire-FirstCall/ - Dr. Brad Thompson, President,and CEO of ... conference call and webcast on Tuesday, November 4, ... update investors on recent clinical trial,results for REOLYSIN(R), ... pivotal trial., To access the conference call ...
... Outstanding Teachers Will Be Recognized in Communities Where Amgen ... ... Amgen (Nasdaq: AMGN ),today announced that it now invites applications for ... designed to,recognize and honor extraordinary science teachers at the K-12 level who,significantly ...
Cached Biology Technology:DURECT Corporation Announces Third Quarter 2008 Financial Results 2DURECT Corporation Announces Third Quarter 2008 Financial Results 3DURECT Corporation Announces Third Quarter 2008 Financial Results 4DURECT Corporation Announces Third Quarter 2008 Financial Results 5DURECT Corporation Announces Third Quarter 2008 Financial Results 6DURECT Corporation Announces Third Quarter 2008 Financial Results 7DURECT Corporation Announces Third Quarter 2008 Financial Results 8Oncolytics Biotech Inc. Announces Clinical Update Conference Call 2Call for Applications: The Amgen Award for Science Teaching Excellence 2Call for Applications: The Amgen Award for Science Teaching Excellence 3
... demand is causing shortages in your laboratory or ... cause unwanted distractions, problems and delays. ... work and endeavour! Bring us your idea and ... internationally. We work under ISO 9001 quality assurance ...
... PBL's bioassays for interferons are cytopathic effect ... assays. Sample types include; tissue culture supernatents; ... In these assays, one unit is defined as ... reduce the cytopathic effect of viral infection by ...
Topoisomerase I...
... Topoisomerase I from vaccinia virus is a ... positive and negative superhelical turns (also called ... DNA. The product of the reaction is ... positive or negative superhelical turns. DNA Topoisomerase ...
Biology Products: