Navigation Links
MS drug shows promise for preventing heart failure
Date:7/16/2013

A drug already approved to treat multiple sclerosis may also hold promise for treating cardiac hypertrophy, or thickening of the cardiac muscle--a disorder that often leads to heart failure, researchers at the University of Illinois at Chicago College of Medicine report.

The findings are published in the July 16 issue of Circulation: Heart Failure.

Cardiac hypertrophy is a slow thickening of the heart muscle that shrinks the interior volume of the heart, forcing the organ to work harder to pump a diminishing volume of blood.

"There comes a day when the heart just can't keep up any more, and it fails," says R. John Solaro, UIC distinguished university professor and head of physiology and biophysics.

Cardiac hypertrophy, which afflicts one in 500 people, can be caused by high blood pressure or inherited through genes that control contraction of the heart.

Solaro and his colleagues believe that if the thickening of the heart muscle could be slowed, or maybe even reversed, heart failure could be prevented.

Solaro and his UIC colleague Yunbo Ke, research assistant professor of physiology and biophysics, were interested in a chemical derived from a fungus used in traditional Chinese medicine as an eternal-youth nostrum. That compound, designated FTY-720, has been developed into a drug to treat multiple sclerosis and is a chemical cousin to the drug most widely used to suppress the immune system and prevent organ rejection in transplant patients.

The substance, Solaro said, "mimics certain lipids in the body that play a role in the development of cardiac hypertrophy."

Using an experimental mouse model of cardiac hypertrophy, Solaro and his team found that FTY-720 significantly reduced heart mass; lessened fibrosis, or stiffening of the heart muscle; and improved overall cardiac function in the mice that received the drug.

The researchers also showed that the drug inhibits expressi
'/>"/>

Contact: Sharon Parmet
sparmet@uic.edu
312-413-2695
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genetic survey of endangered Antarctic blue whales shows surprising diversity
2. University of Houston study shows BP oil spill hurt marshes, but recovery possible
3. Weakness can be an advantage in surviving deadly parasites, a new study shows
4. Study shows unified process of evolution in bacteria and sexual eukaryotes
5. Sexual reproduction brings long-term benefits, study shows
6. UCSB study shows forest insects and diseases arrive in US via imported plants
7. Study shows botanical formula fights prostate cancer
8. Transcatheter aortic valve implantation shows promise in patients with severe aortic stenosis
9. Buy coal? New analysis shows purchasing fossil fuel deposits best way to fight climate change
10. Global Surgical Devices Market Growth Driven by Improving Standards of Living and Longer Life Expectancies, Research Shows
11. CU research shows warming climate threatens ecology at mountain research site west of Boulder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... held in New York City on September 19, 2014, ... Cancer Society Professor of Genome Sciences and Medicine at ... Doctor of Philosophy of Tel Aviv University, was awarded ... , In addition to her honorary degree from TAU, ... TAU School of Medicine, and for the past 18 ...
(Date:10/29/2014)... is available in German . ... Gabriela Cabral and Peter Schlögelhofer at the Max F. ... the Medical University of Vienna dived into the process ... these plants display an inversion of the standard meiotic ... scientific journal Nature Communications . , Meiosis is ...
(Date:10/29/2014)... of the Barcode of Life Data Systems ... Biodiversity Data Journal (BDJ) used specimen records ... into a human-readable text developed in manuscript within the ... to study the species distributions of ten Nearctic species ... is originally designed to support the generation and application ...
Breaking Biology News(10 mins):Geneticist and humanitarian: Prof. Mary-Claire King receives Lasker Award 2Meiotic cell division 'the other way round' 2Go straight and publish: From Barcode of Life Data Systems to scholarly publishing systems 2
... is a key requirement for good health and alternative cheap, ... that has just been published in the leading American Chemical ... University in co-operation with The University of Botswana describe how ... used for water purification. Flocculation of particulate impurities ...
... A rapid and unprecedented proliferation of oil and gas ... area leased is on track to reach around 70% ... is one of the central conclusions from a pair ... Ambientals (ICTA) of Universitat Autnoma de Barcelona (UAB), and ...
... for the Advancement of Science (AAAS) meeting is being ... will be presenting on topics ranging from linear colliders ... Also occurring at the end of this year,s ... as the next president of the AAAS. Below is ...
Cached Biology News:Seeds from the Moringa tree can be used for water purification 2A second hydrocarbon boom threatens the Peruvian Amazon 2A second hydrocarbon boom threatens the Peruvian Amazon 3Caltech researchers presenting at AAAS Meeting 2Caltech researchers presenting at AAAS Meeting 3Caltech researchers presenting at AAAS Meeting 4Caltech researchers presenting at AAAS Meeting 5Caltech researchers presenting at AAAS Meeting 6
(Date:10/30/2014)... Dallas, Texas (PRWEB) October 30, 2014 ... China Naltrexone HCL Industry” is a professional and ... The report provides basic Naltrexone HCL information, including ... as well as industry overview. This research covers ... as well as global industry analysis covering macroeconomic ...
(Date:10/30/2014)... Spartan Bioscience announced today that Health Canada has ... detects CYP2C19 genetic mutations in less than 60 minutes ... CYP2C19 System is the first near-patient DNA test for ... to the system’s ease of use, Health Canada has ... such as doctors, nurses, pharmacists, and laboratory technicians, in ...
(Date:10/30/2014)... Oct. 30, 2014 A new report, commissioned ... Practice, takes an in-depth look at Indiana,s ... have resulted over two different time frames: 1993 to ... view of future opportunities for investment growth.  The ... report shows gains in innovation dollars as well ...
(Date:10/27/2014)... (PRWEB) October 27, 2014 The ... by Type (High & Medium), Sub-type (Primary & ... Processing, Infrastructure & Transportation & Power Generation) - ... the GIS market with analysis and forecasting of ... Market Data Tables with 52 Figures spread through ...
Breaking Biology Technology:Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 2Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 3Health Canada approves first near-patient DNA test for personalized medicine 2Health Canada approves first near-patient DNA test for personalized medicine 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 2New report shows Indiana's gains in life sciences innovation capital outpace the nation 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 4New report shows Indiana's gains in life sciences innovation capital outpace the nation 5Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 3Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 4
... Prize, Draper Laboratory, in conjunction with the National Academy of Engineering ... learn about the impact engineers have had on our daily lives, ... been awarded "Engineering,s Nobel" since 1989. , ... Cambridge, ...
... Inc.,(Nasdaq: PCYC ), a developmental stage biopharmaceutical ... late stage preclinical programs,announced today the appointment of a ... Robert W. Duggan, our Chairman of ... acting as interim CEO for the past five months. ...
... Savient Pharmaceuticals, Inc. (Nasdaq: SVNT ) today ... position of Vice President, Chief Financial Officer & Treasurer. ... terminated as Savient,s Chief Financial Officer, effective immediately. ... our current Vice President of Corporate Finance and Controller, ...
Cached Biology Technology:New Educational Website Celebrates the Accomplishments of Engineers 2Pharmacyclics Announces Appointment of New Management Team and Board Director to Accelerate Its Future Growth 2Pharmacyclics Announces Appointment of New Management Team and Board Director to Accelerate Its Future Growth 3Pharmacyclics Announces Appointment of New Management Team and Board Director to Accelerate Its Future Growth 4Pharmacyclics Announces Appointment of New Management Team and Board Director to Accelerate Its Future Growth 5Pharmacyclics Announces Appointment of New Management Team and Board Director to Accelerate Its Future Growth 6Savient Announces Appointment of David Gionco as Chief Financial Officer 2Savient Announces Appointment of David Gionco as Chief Financial Officer 3Savient Announces Appointment of David Gionco as Chief Financial Officer 4
... Buffer is a concentrated formulation of a ... capillary action technology, as well as for ... with David Brigati M.D., Department of Pathology, ... buffer is recommended for all the rinsing ...
...
... Intended for users requiring mass detection ... linear MALDI TOF Mass spectrometer is ... applications and for high performance mass ... QA/QC, SNP analysis, protein detection, micro-satellite ...
Rat Aortic Smooth Muscle Cells (RAOSMC) (>500,000 cells)...
Biology Products: