Navigation Links
MRSA strain gained dominance with help from skin bacteria
Date:12/17/2013

Scientists believe they have an explanation for how the most common strain of methicillin-resistant Staphylococcus aureus (MRSA) rapidly rose to prominence. Research published in mBio, the online open-access journal of the American Society for Microbiology, suggests that the strain recently acquired a number of genes from common skin bacteria that allow it to grow and thrive on the skin where other strains of MRSA cannot.

"Over the past 15 years, methicillin-resistant Staphylococcus aureus has become a major public health problem. It is likely that adaptations in specific MRSA lineages drove the spread of MRSA across the United States and allowed it to replace other, less-virulent S. aureus strains," says Paul Planet of Columbia University, the lead author on the study.

Since it was first identified in the late 1990s the USA300 strain of MRSA has undergone an extremely rapid expansion across the United States. It is now the predominant cause of community-acquired MRSA skin and soft tissue infections and has been implicated in MRSA outbreaks among professional football teams. The strain is genetically distinguished from other strains by a cluster of genes known as the arginine catabolic mobile element (ACME.)

"Using phylogenetic analysis, we showed that the modular segments of ACME were assembled into a single genetic locus in Staphylococcus epidermidis (a relatively harmless bacterium typically found on human skin) and then horizontally transferred to the common ancestor of USA300 strains in an extremely recent event that coincided with the emergence and spread of this strain" says Planet.

The researchers identified one ACME gene in particular, called speG, that conferred on USA300 strains the ability to withstand high levels of polyamines, compounds produced by the skin that are toxic to other strains of MRSA. Polyamine tolerance also gave MRSA multiple advantages including enhanced biofilm formation, adherence to host tissues and resistance to certain antibiotics, according to the study.

"We suggest that these properties gave USA 300 a major selective advantage during skin infection and colonization, contributing to the extraordinary evolutionary success of this clone," says Planet.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related biology news :

1. Mount Sinai researchers say new strain of bird flu packs a punch even after becoming drug-resistant
2. Volatile ecosystems, a natural wind tunnel, volcanic lightning, and stress & strain on Venus
3. New test can diagnose emerging strains of canine parvovirus
4. Scientists engineer strain of MERS coronavirus for use in a vaccine
5. Researchers track antibiotic-resistant strains of Salmonella from farm to fork
6. MRSA strain in humans originally came from cattle
7. H7N9 influenza strain resistant to antivirals, but tests fail to identify resistance
8. Hidden strains of HPV found in virus-negative genital warts
9. Researchers create method to rapidly identify specific strains of illness
10. Researchers develop a faster method to identify Salmonella strains
11. New bird flu strain seen adapting to mammals, humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... , April 13, 2017 UBM,s Advanced Design ... will feature emerging and evolving technology through its ... Summits will run alongside the expo portion of the ... panels and demonstrations focused on trending topics within 3D ... design and manufacturing event will take place June 13-15, 2017 ...
(Date:4/11/2017)... 11, 2017 NXT-ID, Inc. (NASDAQ:   ... announces the appointment of independent Directors Mr. Robin D. ... Board of Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , ... forward to their guidance and benefiting from their considerable expertise ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC , ... that the United States Patent and Trademark Office (USPTO) ... covers the linking of an iris image with a ... and represents the company,s 45 th issued patent. ... is very timely given the multi-modal biometric capabilities that ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that give it exclusive ... a technology developed in collaboration with Children’s Hospital Los Angeles (CHLA). ...
(Date:10/10/2017)... ... ... Dr. Bob Harman, founder and CEO of VetStem Biopharma, Inc. ... event entitled “Stem Cells and Their Regenerative Powers,” was held on August 31st, ... was joined by two human doctors: Peter B. Hanson, M.D., Chief of Orthopedic Surgery, ...
(Date:10/10/2017)... SomaGenics announced the receipt of a Phase ... (Single Cell), expected to be the first commercially available ... from single cells using NGS methods. The NIH,s recent ... development of approaches to analyze the heterogeneity of cell ... for measuring levels of mRNAs in individual cells have ...
(Date:10/10/2017)... ... 2017 , ... The Pittcon Program Committee is pleased to ... who have made outstanding contributions to analytical chemistry and applied spectroscopy. Each award ... conference and exposition for laboratory science, which will be held February 26-March 1, ...
Breaking Biology Technology: