Navigation Links
MRSA strain gained dominance with help from skin bacteria
Date:12/17/2013

Scientists believe they have an explanation for how the most common strain of methicillin-resistant Staphylococcus aureus (MRSA) rapidly rose to prominence. Research published in mBio, the online open-access journal of the American Society for Microbiology, suggests that the strain recently acquired a number of genes from common skin bacteria that allow it to grow and thrive on the skin where other strains of MRSA cannot.

"Over the past 15 years, methicillin-resistant Staphylococcus aureus has become a major public health problem. It is likely that adaptations in specific MRSA lineages drove the spread of MRSA across the United States and allowed it to replace other, less-virulent S. aureus strains," says Paul Planet of Columbia University, the lead author on the study.

Since it was first identified in the late 1990s the USA300 strain of MRSA has undergone an extremely rapid expansion across the United States. It is now the predominant cause of community-acquired MRSA skin and soft tissue infections and has been implicated in MRSA outbreaks among professional football teams. The strain is genetically distinguished from other strains by a cluster of genes known as the arginine catabolic mobile element (ACME.)

"Using phylogenetic analysis, we showed that the modular segments of ACME were assembled into a single genetic locus in Staphylococcus epidermidis (a relatively harmless bacterium typically found on human skin) and then horizontally transferred to the common ancestor of USA300 strains in an extremely recent event that coincided with the emergence and spread of this strain" says Planet.

The researchers identified one ACME gene in particular, called speG, that conferred on USA300 strains the ability to withstand high levels of polyamines, compounds produced by the skin that are toxic to other strains of MRSA. Polyamine tolerance also gave MRSA multiple advantages including enhanced biofilm formation, adherence to host tissues and resistance to certain antibiotics, according to the study.

"We suggest that these properties gave USA 300 a major selective advantage during skin infection and colonization, contributing to the extraordinary evolutionary success of this clone," says Planet.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related biology news :

1. Mount Sinai researchers say new strain of bird flu packs a punch even after becoming drug-resistant
2. Volatile ecosystems, a natural wind tunnel, volcanic lightning, and stress & strain on Venus
3. New test can diagnose emerging strains of canine parvovirus
4. Scientists engineer strain of MERS coronavirus for use in a vaccine
5. Researchers track antibiotic-resistant strains of Salmonella from farm to fork
6. MRSA strain in humans originally came from cattle
7. H7N9 influenza strain resistant to antivirals, but tests fail to identify resistance
8. Hidden strains of HPV found in virus-negative genital warts
9. Researchers create method to rapidly identify specific strains of illness
10. Researchers develop a faster method to identify Salmonella strains
11. New bird flu strain seen adapting to mammals, humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2017)...  Socionext Inc., a global expert in SoC-based imaging and computing ... M820, which features the company,s hybrid codec technology. A demonstration utilizing ... Inc., will be showcased during the upcoming Medtec Japan at Tokyo ... Las Vegas Convention Center April 24-27. ... Click here for an image ...
(Date:4/13/2017)... According to a new market research report "Consumer ... Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - ... to grow from USD 14.30 Billion in 2017 to USD 31.75 Billion ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... BROOKLYN, N.Y. , April 11, 2017 /PRNewswire-USNewswire/ ... identical fingerprints, but researchers at the New York ... University College of Engineering have found that partial ... fingerprint-based security systems used in mobile phones and ... previously thought. The vulnerability lies in ...
Breaking Biology News(10 mins):
(Date:8/10/2017)... Yorba Linda, Ca (PRWEB) , ... August 09, ... ... and exosomes for regenerative medicine applications in the clinic is here. The team ... secreted EVs present in conditioned medium for clinical studies. , Dr. Travis ...
(Date:8/10/2017)... ... August 09, 2017 , ... Okyanos Center for Regenerative Medicine has announced ... Bay Hotel in Freeport, Grand Bahama on September 27, 2017. This daytime event is ... oversight from the Ministry of Health’s National Stem Cell Ethics Committee (NSCEC) and regulations ...
(Date:8/10/2017)... ... August 10, 2017 , ... DrugDev and the ... webinar to demonstrate how Good Clinical Practice (GCP) can be used throughout the ... the webinar will discuss the importance of GCP compliance, how sites are affected by ...
(Date:8/10/2017)... ... August 10, 2017 , ... ... news outlet had initiated coverage on Next Group Holdings, Inc. and see's significant ... markets geared toward those that cannot engage in traditional banking services. According to ...
Breaking Biology Technology: