Navigation Links
MRI scans show structural brain changes in people at risk for Alzheimer's disease
Date:11/16/2010

(CHICAGO) New results from a study by neuroscientists at Rush University Medical Center suggest that people at risk of developing Alzheimer's disease exhibit a specific structural change in the brain that can be visualized by brain imaging. The findings may help identify those who would most benefit from early intervention.

The study will be presented at Neuroscience 2010, the annual meeting for the Society of Neuroscience in San Diego, Calif., on Wednesday, November 17.

"One of the main challenges in the field of Alzheimer's disease is identifying individuals at risk of developing Alzheimer's disease so that therapeutic interventions developed in the future can be given at the earliest stage before symptoms begin to appear," said Sarah George, a graduate student who co-authored the study with Leyla deToledo-Morrell, PhD, director of the graduate program in neuroscience at Rush University Medical Center and professor of neurological sciences at the Graduate College of Rush University.

"Our study has found that structural imaging techniques can be used to identify those at risk for developing Alzheimer's disease," said deToledo-Morrell.

For the study, experts from Rush followed individuals with mild cognitive impairment, which is thought to be a precursor of Alzheimer's disease and other forms of dementia. Those with mild cognitive impairment can exhibit memory decline known as amnestic mild cognitive impairment.

Researchers followed 52 individuals with amnestic mild cognitive impairment over a period of six years. Twenty-three participants progressed to Alzheimer's disease.

Study participants underwent magnetic resonance imaging (MRI) screenings. The researchers used MRI to look for structural changes in the substantia innominata (SI), a region deep within the brain that sends chemical signals to the cerebral cortex, the brain's outer layer that is largely responsible for reasoning, memory and other higher functions. Although no structural changes were found in the SI between the two groups, the MRI showed a thinning of the cortical areas that receive strong input from the SI in those who went on to develop Alzheimer's disease.

"Since we were able to distinguish those who progressed to Alzheimer's disease compared to those who remained stable, we believe that MRI techniques that examine patterns of structural alterations provide a sensitive biomarker for detecting risk of Alzheimer's disease," said George.


'/>"/>

Contact: Deb Song
deb_song@rush.edu
312-942-0588
Rush University Medical Center
Source:Eurekalert

Related biology news :

1. Brain scans detect autisms signature
2. Helical CT scans reduce lung cancer mortality by 20 percent compared to chest X-rays
3. PET scans reveal estrogen-producing hotspots in human brain
4. Study of severe asthma using CT scans
5. CT scans reveal that dinosaurs were airheads
6. New discovery may enhance MRI scans, lead to portable MRI machines
7. Structural genomics accelerates protein structure determination
8. Structural Genomics Consortium releases 1,000th protein structure
9. Pitt/Iowa team finds cellular structural molecule can be toxic: Makes pneumonia worse
10. Structural defects precede functional decline in heart muscle
11. University of Nevada professor studies structural basis for autism disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... GOTHENBURG, Sweden , April 28, 2016 ... 1,491.2 M (139.9), up 966% compared with the first quarter of ... Operating profit totaled SEK 589.1 M (loss: 18.8) and the operating ... SEK 7.12 (loss: 0.32) Cash flow from operations was ... , The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
(Date:4/15/2016)... 15, 2016  A new partnership announced today ... underwriting decisions in a fraction of the time ... and high-value life insurance policies to consumers without ... With Force Diagnostics, rapid testing (A1C, Cotinine and ... (blood pressure, weight, pulse, BMI, and activity data) ...
(Date:3/31/2016)... 31, 2016   ... the "Company") LegacyXChange is excited to release ... soon to be launched online site for trading 100% ... ) will also provide potential shareholders a sense of ... to an industry that is notorious for fraud. The ...
Breaking Biology News(10 mins):
(Date:5/23/2016)... , May 23, 2016 - Leading ... 40% - Frontage Implement a Single Platform to Manage ... and Traceability Within the Bioanalytical lab Frontage Laboratories, a ... United States and China , has ... laboratory facilities. In addition to serving as the global electronic lab ...
(Date:5/23/2016)... ... May 23, 2016 , ... ... molecular nanotechnology, announced the winners for the 2015 Foresight Institute Feynman Prizes. ... given in two categories, one for experiment and the other for theory in ...
(Date:5/20/2016)... San Diego, CA (PRWEB) , ... May 20, 2016 , ... ... announce that 10 of its most experienced veterinary clients have treated over 100 of ... this cutting edge technology to provide the highest level of care for their patients. ...
(Date:5/20/2016)... ... ... Korean researchers say Manumycin A triggers apoptosis, or natural cell death, in ... disease. Surviving Mesothelioma has just posted an article on the new study. Click ... mesothelioma study on the fact the Manumycin A, a derivative of Streptomyces parvulus, is ...
Breaking Biology Technology: