Navigation Links
MRI scans show structural brain changes in people at risk for Alzheimer's disease

(CHICAGO) New results from a study by neuroscientists at Rush University Medical Center suggest that people at risk of developing Alzheimer's disease exhibit a specific structural change in the brain that can be visualized by brain imaging. The findings may help identify those who would most benefit from early intervention.

The study will be presented at Neuroscience 2010, the annual meeting for the Society of Neuroscience in San Diego, Calif., on Wednesday, November 17.

"One of the main challenges in the field of Alzheimer's disease is identifying individuals at risk of developing Alzheimer's disease so that therapeutic interventions developed in the future can be given at the earliest stage before symptoms begin to appear," said Sarah George, a graduate student who co-authored the study with Leyla deToledo-Morrell, PhD, director of the graduate program in neuroscience at Rush University Medical Center and professor of neurological sciences at the Graduate College of Rush University.

"Our study has found that structural imaging techniques can be used to identify those at risk for developing Alzheimer's disease," said deToledo-Morrell.

For the study, experts from Rush followed individuals with mild cognitive impairment, which is thought to be a precursor of Alzheimer's disease and other forms of dementia. Those with mild cognitive impairment can exhibit memory decline known as amnestic mild cognitive impairment.

Researchers followed 52 individuals with amnestic mild cognitive impairment over a period of six years. Twenty-three participants progressed to Alzheimer's disease.

Study participants underwent magnetic resonance imaging (MRI) screenings. The researchers used MRI to look for structural changes in the substantia innominata (SI), a region deep within the brain that sends chemical signals to the cerebral cortex, the brain's outer layer that is largely responsible for reasoning, memory and other higher functions. Although no structural changes were found in the SI between the two groups, the MRI showed a thinning of the cortical areas that receive strong input from the SI in those who went on to develop Alzheimer's disease.

"Since we were able to distinguish those who progressed to Alzheimer's disease compared to those who remained stable, we believe that MRI techniques that examine patterns of structural alterations provide a sensitive biomarker for detecting risk of Alzheimer's disease," said George.


Contact: Deb Song
Rush University Medical Center

Related biology news :

1. Brain scans detect autisms signature
2. Helical CT scans reduce lung cancer mortality by 20 percent compared to chest X-rays
3. PET scans reveal estrogen-producing hotspots in human brain
4. Study of severe asthma using CT scans
5. CT scans reveal that dinosaurs were airheads
6. New discovery may enhance MRI scans, lead to portable MRI machines
7. Structural genomics accelerates protein structure determination
8. Structural Genomics Consortium releases 1,000th protein structure
9. Pitt/Iowa team finds cellular structural molecule can be toxic: Makes pneumonia worse
10. Structural defects precede functional decline in heart muscle
11. University of Nevada professor studies structural basis for autism disorders
Post Your Comments:
(Date:10/27/2015)... 2015 In the present market scenario, security ... various industry verticals such as banking, healthcare, defense, electronic ... demand for secure & simplified access control and growing ... hacking of bank accounts, misuse of users, , and ... PC,s, laptops, and smartphones are expected to provide potential ...
(Date:10/26/2015)... October 26, 2015 ... adds Biometrics Market Shares, ... as well as Emerging Biometrics Technologies: ... to its collection of IT and ... . --> ...
(Date:10/23/2015)... DUBLIN , Oct. 23, 2015 Research ... of the "Global Voice Recognition Biometrics Market 2015-2019" ... --> --> The global voice recognition ... during 2014-2019. --> ... 2015-2019, has been prepared based on an in-depth market ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... , Nov. 24, 2015 /PRNewswire/ - Aeterna ... announced today that the remaining 11,000 post-share consolidation ... Purchase Warrants (the "Series B Warrants") subject to ... exercised on November 23, 2015, which will result ... After giving effect to the issuance of such ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... ... customer, OrthoAccel® Technologies, Inc., on being named to Deloitte's 2015 Technology Fast 500 ... Texas facility, OrthoAccel manufactures AcceleDent®, a FDA-cleared, Class II medical device that speeds ...
(Date:11/24/2015)... Nov. 24, 2015  PDL BioPharma, Inc. (PDL) (NASDAQ: ... the company,s president and chief executive officer, will present at ... week in New York City . The ... December 1, 2015 at 9:30 a.m. EST. ... the website at least 15 minutes prior to the presentation ...
(Date:11/23/2015)... Nov. 24, 2015 Women with a certain type ... face a higher risk of lung cancer than men with ... week at the annual meeting of the Radiological Society of ... --> --> Lung nodules are small ... solid or subsolid based on their appearance on CT. Solid ...
Breaking Biology Technology: