Navigation Links
MRI measure of blood flow over atherosclerotic plaque may detect dangerous plaque

(Boston) Researchers from Boston University School of Medicine (BUSM) have shown that using magnetic resonance imaging (MRI) to measure blood flow over atherosclerotic plaques could help identify plaques at risk for thrombosis. The findings, which appear in the March issue of Circulation Cardiovascular Imaging, offer a non-invasive application in the diagnosis and treatment of patients with atherosclerosis.

Atherosclerosis is a chronic disease of the human vascular system associated with lipid (cholesterol) accumulation and inflammation. It can remain silent and undetected for many years, but can cause acute cardiovascular events such as stroke or heart attack. This often occurs when a high-risk, dangerous atherosclerotic plaque disrupts at the vessel surface facing the blood, followed by partial or complete blockage of blood flow through the lumen by a thrombus. An unmet challenge of diagnostic medicine is to find such plaques before disruption occurs in order to prevent these occurrences.

While most studies have focused on the plaque within the vessel wall, the flow of blood in the vessel (hemodynamics) also is known to be important in the progression and disruption of plaques.

In this study the researchers, led by James A. Hamilton, PhD, professor of biophysics and physiology at BUSM, found that the measurement of endothelial sheer stress (ESS), which is the indirect stress from the friction of blood flow over the vascular endothelium surface, can identify plaques in the highest risk category. After performing a non-invasive MRI examination of the aorta in a preclinical model with both stable and unstable plaques, a pharmacological "trigger" was used to induce plaque disruption. Low ESS was associated with plaques that disrupted and had other "high-risk" features, such as positive remodeling, which is an outward expansion of the vessel wall that "hides" the plaque from detection by many conventional methods.

These results are consistent with previous studies that examined coronary arteries of other experimental models using invasive intravascular ultrasound method to measure features of vulnerability but without an endpoint of plaque disruption, which is the outcome of the highest risk plaques.

"Our results indicate that using non-invasive MRI assessments of ESS together with the structural characteristics of the plaque offers a comprehensive way to identify the location of "high-risk" plaque, monitor its progression and assess the effect of interventions," said Hamilton. "Early identification of "high-risk" plaques prior to acute cardiovascular events will provide enhanced decision making and might improve patient management by allowing prompt aggressive interventions that aim to stabilize plaques."


Contact: Jenny Eriksen
Boston University Medical Center

Related biology news :

1. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
2. Microbiologists can now measure extremely slow life
3. New Center for Carbon Measurement to drive UKs low carbon economy
4. NASA satellite measurements imply Texas wind farm impact on surface temperature
5. New study by WHOI scientists provides baseline measurements of carbon in Arctic Ocean
6. Not-so-precious: Stripping gold from AFM probes allows better measurement of picoscale forces
7. SMOS satellite measurements improve as ground radars switch off
8. First seabed sonar to measure marine energy effect on environment and wildlife
9. ATP splitting in membrane protein dynamically measured for the first time
10. Ship-borne measurements show EU policies have improved air quality in harbors
11. Researchers develop rapid method to measure carbon footprints
Post Your Comments:
(Date:11/12/2015)... CAMBRIDGE, Mass. , Nov. 12, 2015 /PRNewswire/ ... Broad Institute of MIT and Harvard for use ... chemical discovery information management tools. The partnership will ... share both biological and chemical research information internally ... tools will be used for managing the Institute,s ...
(Date:11/10/2015)... NEW YORK , Nov. 10, 2015 /PRNewswire/ ... refers to behavioral biometrics that helps to identify ... prevent fraud. Signature is considered as the secure ... for the identification of a particular individual because ... offers more accurate results especially when dynamic signature ...
(Date:11/2/2015)... , Nov. 2, 2015  SRI International has ... to provide preclinical development services to the National Cancer ... SRI will provide scientific expertise, modern testing and support ... of preclinical pharmacology and toxicology studies to evaluate potential ... --> The PREVENT Cancer Drug Development Program is ...
Breaking Biology News(10 mins):
(Date:11/30/2015)... , Nov. 30, 2015 /PRNewswire/ - Zenith Epigenetics Corp. ("Zenith" ... Norman C.W. Wong to its Board of Directors ... to Zenith with a wealth of experience as co-founder of ... biology. --> --> Dr. ... Epigenetics, board of directors. Zenith,s long standing expertise in epigenetics ...
(Date:11/30/2015)... 2015  Champions Oncology, Inc. (CSBR), engaged in the ... the development and use of oncology drugs, today announced ... be presenting at the LD MICRO Investor Conference on ... (PST).  The conference, held at the Luxe Sunset Bel ... , will feature 200 small/micro-cap companies and is expected ...
(Date:11/30/2015)... Nov. 30, 2015  HUYA Bioscience International, the leader ... pharmaceutical innovations, today announced it has signed a ... (KDDF) to foster collaboration between KDDF and HUYA with ... of healthcare products for the global market. ... source of new innovative preclinical and clinical stage compounds. ...
(Date:11/30/2015)... and MAGDEBURG, Germany , November ... NeuroRehabilitation (ECNR) in Vienna, Austria ... European Congress of NeuroRehabilitation (ECNR) in Vienna, ... --> NovaVision, a wholly owned subsidiary of Vycor Medical, ... version of its Internet-delivered NovaVision Therapy Suite at the ...
Breaking Biology Technology: