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MRI may be noninvasive method to measure breast cancer prognosis
Date:12/8/2011

inally associated with one of the DCE measures. Each of the DCE kinetics parameters significantly discriminated grade III tumors from grades I and II and luminal A from luminal B and basal-like intrinsic subtypes.

"When we looked at these measures, we realized there was a correlation with biomarkers," Parsian said.

Although these are preliminary data, she hopes that someday MRI might provide valuable noninvasive information about tumor biology for selecting and guiding targeted therapies.

Parsian said larger prospective studies are needed to confirm these results and that MRI may complement biopsy to sample the whole tumor and reflect tumor heterogeneity.

"I think the final goal of radiology is to get more information while doing the least amount of intervention possible for the patient," she said. "It would be great if we could improve our understanding of breast cancer biology and predict response to different therapies with imaging. Our study suggests MRI may play a valuable role in this process."


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Contact: Jeremy Moore
Jeremy.Moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

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