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MRI contrast agents change stem cell proliferation
Date:11/1/2010

f Sinerem and Endorem were needed for cell labeling to achieve similar MRI detectability."

The researchers concluded that it will be necessary to evaluate the efficiency of cell labeling for every new contrast agent combination aimed at being followed in vivo by MRI. Also, the effect on biological behavior of cells should be examined. They noted that their results were limited to examining the effects of labeling on proliferation, not differentiation.

"Although labeling of stem cells with MRI is promising, there are some limitations," concluded Dr. Crabbe. "More optimal particles are needed that can be taken up without the need of potentially toxic agents. Also, there is the problem of particle dilution over time as cells divide. When grafted cells continue to proliferate, loss of signal occurs."

According to Dr. Julio Voltarelli, professor of clinical medicine and clinical immunology at the University of Sao Pulo, Brazil and section editor for Cell Transplantation there has been a knowledge gap regarding the survival and distribution of stem cell populations used for in vivo therapy.

"Many studies have tried to close this gap by using radioactive or nonradioactive labeling of the cells in order to follow their fate in the organism," said Dr. Voltarelli. "However, this paper demonstrates that such labeling may alter stem cell behavior, such as proliferative potential, and give biased information when compared to nonlabeled cells."


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Contact: David Eve
celltransplantation@gmail.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

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