Navigation Links
MNI researchers locate neurological basis of depression following sports concussion
Date:1/18/2008

This release is also available in French.

Researchers at the Montreal Neurological Institute of McGill University have identified the neurological basis of depression in male athletes with persisting post-concussion symptoms. The study, published in this weeks issue of Archives of General Psychiatry, has important clinical implications for the treatment of individuals who have suffered a cerebral concussion.

Depression is one of a number of persisting symptoms experienced by athletes following sports concussion. The prevalence of depression in the general population is around 5%, whilst the prevalence of depression in head trauma patients can reach an astounding 40 %.

Until now, very little was known about the neurological basis of the depression frequently reported by athletes following concussion, says Dr. Alain Ptito, neuropsychologist and researcher at the MNI, and lead investigator for the study. Traditional testing methods for concussion yielded normal results with no obvious cognitive or neurological deficits. Persistent complaints have been perceived as subjective and ill-defined without neurological basis. Injury to the brain following concussion takes place at a microscopic level and is therefore difficult to measure in a patient.

Using enhanced brain imaging technology, researchers are now able to gain new insights into the damage caused by concussion. Using functional MRI (fMRI), a computerized imaging technique that measures blood oxygen levels, we were able to detect areas of the brain with abnormal neural activity, explained Dr. Ptito. Dr. Ptito and colleagues tested fifty-six male athletes, 40 with concussion and 16 healthy controls. Using a depression index, 16 of the concussed subjects had no symptoms of depression, 16 expressed mild depression and 8 had moderate symptoms of depressions. Concussed athletes with depression showed reduced brain activity in regions known to be implicated in depression, specifically, the dorsolateral prefrontal cortex and striatum and attenuated deactivation in medial frontal and temporal regions. We discovered that concussed subjects with depression presented with the same pattern of brain activation as that seen for patients with major depression.

Other studies have shown a link between a history of brain injury and probability of developing major depression later in life. Therefore understanding the pathology of depression in concussed subjects has important implications for early intervention and successful outcomes.


'/>"/>

Contact: Anita Kar
anita.kar@mcgill.ca
514-398-3376
Montreal Neurological Institute and Hospital
Source:Eurekalert

Related biology news :

1. Researchers reveal HIV peptides possible pathway into the cell
2. USC researchers identify mechanism that controls activation of stem cells during hair regeneration
3. Researchers put the bite on mosquitoes
4. Researchers find association between food insecurity and developmental risk in children
5. Iowa State researchers look for smaller, cheaper, 1-dose vaccines
6. Japanese and German researchers meet to discuss climate change
7. Type 1 diabetes triggered by lazy regulatory T-cells: McGill researchers
8. Researchers uncover new piece to the puzzle of human height
9. Researchers create mathematical model of fruit fly eyes
10. Snoozing worms help Penn researchers explain the evolution of sleep
11. Researchers move 2 steps closer to understanding genetic underpinnings of autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/4/2017)... 2017   EyeLock LLC , a leader of ... States Patent and Trademark Office (USPTO) has issued U.S. ... of an iris image with a face image acquired ... company,s 45 th issued patent. ... given the multi-modal biometric capabilities that have recently come ...
(Date:3/30/2017)... , March 30, 2017 Trends, opportunities ... (physiological and behavioral), by technology (fingerprint, AFIS, iris recognition, ... recognition, and others), by end use industry (government and ... immigration, financial and banking, and others), and by region ... , Asia Pacific , and ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... They ... a complex biological network, a depiction of a system of linkages and connections ... Korkin, PhD, associate professor of computer science at Worcester Polytechnic Institute (WPI) and ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... with the addition of its newest module, US Hemostats & Sealants. , SmartTRAK’s ... hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic sealants used in surgical ...
(Date:10/11/2017)... ... 11, 2017 , ... The CRISPR-Cas9 system has ... and avoiding the use of exogenous expression plasmids. The simplicity of programming this ... gain-of-function studies. , This complement to loss-of-function studies, such as with RNAi ...
(Date:10/11/2017)...  VMS BioMarketing, a leading provider of patient support solutions, ... Educator (CNE) network, which will launch this week. The VMS ... care professionals to enhance the patient care experience by delivering ... health care professionals to help women who have been diagnosed ... ...
Breaking Biology Technology: