Navigation Links
MMV and SCYNEXIS offer 400 active compounds for neglected disease drug research at no cost
Date:12/19/2011

In a bid to catalyse malaria and neglected disease drug discovery, MMV and SCYNEXIS, Inc. have assembled a Malaria Box of 400 carefully selected commercially available compounds with antimalarial activity and will provide it to researchers at no cost.

All 400 compounds in the Malaria Box have confirmed activity against the blood-stage of P. falciparum the most deadly of the malaria parasites and were selected by experienced medicinal chemists from an extensive screening of around four million compounds from the chemical libraries of St. Jude Children's Research Hospital, Novartis and GlaxoSmithKline. The Malaria Box includes 200 drug-like compounds as starting points for oral drug discovery as well as 200 probe-like compounds representing the broadest cross-section of chemical diversity for use as biological tools.

"The discovery of novel molecules to feed the pipeline of antimalarial drugs remains a constant challenge," said Tim Wells, CSO of Medicines for Malaria Venture, "and all the more pressing in light of emerging resistance to current therapies. One of the rate-limiting factors for drug discovery is access to the actual active compounds with which to conduct research. With the Malaria Box concept, together with our partner SCYNEXIS, we hope to overcome this hurdle by carefully selecting and making available the most promising molecules to propel malaria drug discovery to the next level."

The scope of the Malaria Box goes beyond the malaria field as the compounds could also be used in research for drugs for other parasitic or neglected diseases. Making the compounds available to the entire neglected-disease community could lead to a better understanding of the similarities and differences between these diseases.

"SCYNEXIS is pleased to participate with MMV in the Malaria Box project as part of our on-going commitment to address the tremendous challenges presented by neglected diseases," said Yves Ribeill, President & CEO of SCYNEXIS, Inc. "SCYNEXIS stands ready to direct its proprietary technologies including its Integrated Parasitology Screening Platform and its HEOS Collaborative Discovery Information Software Platform along with its highly experienced drug discovery teams to find innovative cures for these diseases."

The Malaria Box can be requested free-of-charge from MMV's website. All that is asked in return is that any data gleaned from research on the Box is published, shared and placed into the public domain to continue the virtuous cycle of research.


'/>"/>
Contact: Jaya Banerji
banerjij@mmv.org
41-079-707-7181
Medicines for Malaria Venture
Source:Eurekalert

Related biology news :

1. BI-Clinical Offers 100% Coverage of All ACO Quality Measures Released by CMS
2. Ancient dry spells offer clues about the future of drought
3. Cheap beads offer alternative solar-heating storage
4. 2 top biological imaging centers offer powerful free online tool to researchers and public
5. Submarine springs offer preview of ocean acidification effects on coral reefs
6. BI-Clinical Offers 100% Coverage of All ACO Quality Measures Released by CMS
7. Targeted antibacterial proteins may offer antibiotic alternative
8. Novel monoclonal antibody offers potential treatment for tumors resistant to VEGF therapy
9. Ultrathin flexible brain implant offers unique look at seizures in NIH-funded research
10. New report offers broad approach to assessing impacts of ecological damage
11. Evolution offers clues to leading cause of death during childbirth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... VILNIUS, Lithuania , March 21, 2017 /PRNewswire/ ... identification and object recognition technologies, today announced the ... development kit (SDK), which provides improved facial recognition ... safety cameras on a single computer. The new ... algorithms to improve accuracy, and it utilizes a ...
(Date:3/20/2017)... At this year,s CeBIT Chancellor Dr. Angela Merkel visited the ... the DERMALOG stand together with the Japanese Prime Minster Shinzo Abe. ... largest German biometrics company the two government leaders could see the three ... as DERMALOG´s multi-biometrics system.   Continue Reading ... ...
(Date:3/13/2017)... 13, 2017 Future of security: Biometric Face Matching software  ... ... DERMALOGs Face Matching enables to match face pictures against each other ... identify individuals. (PRNewsFoto/Dermalog Identification Systems) ... DERMALOG,s "Face Matching" is the fastest software for biometric Face Matching on the ...
Breaking Biology News(10 mins):
(Date:3/24/2017)... 2017   Sienna Biopharmaceuticals, Inc. , a privately ... that Richard Peterson will join the company ... Peterson, who brings more than two decades of global ... is retiring at the end of April but will ... joins Sienna from Novan, Inc., where he served as ...
(Date:3/23/2017)... BETHESDA, Md. , March 23, 2017 /PRNewswire/ ... company developing DCVax® personalized immune therapies for solid ... on the $7.5 million financing it announced last ... Company sold to several institutional investors securities totaling ... $.26 per share, and 10,000,000 shares of Class ...
(Date:3/23/2017)... 2017 Kineta, Inc., a biotechnology company ... in immuno-oncology, today announced the discovery and characterization ... that activate interferon response factor 3 (IRF3) via ... tumor regression in a murine colon carcinoma mouse ... complete tumor regression to initial drug treatment were ...
(Date:3/23/2017)... ... March 23, 2017 , ... Advanced ... the hire of Dr. Sigmund “Sig” Floyd as Vice President ? Global Business ... joint development activities. , “Dr. Floyd’s career has spanned 30 years in the ...
Breaking Biology Technology: