Navigation Links
MIT systems biologists use computer models to predict animal cell behavior
Date:3/23/2011

CAMBRIDGE, Mass. -- Biological systems, including cells, tissues and organs, can function properly only when their parts are working in harmony. These systems are often dauntingly complex: Inside a single cell, thousands of proteins interact with each other to determine how the cell will develop and respond to its environment.

To understand this great complexity, a growing number of biologists and bioengineers are turning to computational models. This approach, known as systems biology, has been used successfully to model the behavior of cells grown in laboratory dishes. However, until now, no one has used it to model the behavior of cells inside a living animal.

In the March 22 online edition of the journal Science Signaling, researchers from MIT and Massachusetts General Hospital report that they have created a new computational model that describes how intestinal cells in mice respond to a natural chemical called tumor necrosis factor (TNF).

The work demonstrates that systems biology offers a way to get a handle on the complexity of living systems and raises the possibility that it could be used to model cancer and other complex diseases, says Douglas Lauffenburger, head of MIT's Department of Biological Engineering and a senior author of the paper.

"You're not likely to explain most diseases in terms of one genetic deficit or one molecular impairment," Lauffenburger says. "You need to understand how many molecular components, working in concert, give rise to how cells and tissues are formed either properly or improperly."

Systems biology, a field that has grown dramatically in the past 10 years, focuses on analyzing how the components of a biological system interact to produce the behavior of that system for example, the many proteins that interact with each other inside a cell to respond to hormones or other external stimuli.

"The beauty of systems biology is that it doesn't ignore the biologic
'/>"/>

Contact: Caroline McCall
cmccall5@mit.edu
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New Systems Biology Awards enable detailed study of microbes
2. ICSU launches new program to understand the human impact on Earths life-support systems
3. SAIC Awarded $37 Million Contract to Support U.S. Army Program Executive Office - Enterprise Information Systems
4. Kalyon wins Thomas Baron Award in Fluid-Particle Systems
5. Researchers apply systems biology and glycomics to study human inflammatory diseases
6. Complex systems and Mars missions help understand how life began
7. Systems biology brings hope of speeding up drug development
8. Carnegie Mellon developing automated systems to enable precision farming of apples, oranges
9. Toward a systems biology map of iron metabolism
10. Old and young brains rely on different systems to remember emotional content
11. Ocean acidification could have broad effects on marine ecosystems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... RALEIGH, N.C. , Dec. 16, 2014 Valencell, ... licensed its PerformTek biometric technology to industry leaders such ... highly accurate, clinically validated, biometric wearable products. These products ... 6-9 in Las Vegas . ...
(Date:12/15/2014)... Dec. 12, 2014 Research and Markets ( ... "Global Facial Recognition Market 2015-2019" report to their ... Facial recognition is a technology used for the ... facial feature of a person such as nose, jaw ...
(Date:12/11/2014)...  That blood pressure plays a role in human health has ... term for high blood pressure – was first described as ... that,s used in measuring blood pressure was invented in 1896. ... hypertension, its triggers and its effects. In fact, recent findings ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... One of the few studies of its type has found ... Oregon university were "food insecure" at some point during the ... emotional health and other issues. Contrary to concerns about ... weight gain, another reality is that many students are not ...
... The sponges of the future will do more than clean ... to soak up a drug and deliver it directly to a ... store unwanted gases. These technologies are what University at ... when he led the design of a new material called UBMOF-1. ...
... to kill insects and fungi also kill honeybee larvae within ... researchers. The team also found that N-methyl-2-pyrrolidone (NMP) -- an ... -- is highly toxic to honeybee larvae. "We found ... kill bee larvae," said Jim Frazier, professor of entomology, Penn ...
Cached Biology News:Study identifies high level of 'food insecurity' among college students 2Study identifies high level of 'food insecurity' among college students 3Swiss cheese crystal, or high-tech sponge? 2Common crop pesticides kill honeybee larvae in the hive 2Common crop pesticides kill honeybee larvae in the hive 3
(Date:12/24/2014)... 2014  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical ... that the Company closed its previously announced private ... Jack W. Schuler , Birchview Fund LLC and ... before offering expenses.  The proceeds will be used ...
(Date:12/24/2014)... 2014 “Preparative & Process Chromatography ... Consumables (Columns, Solvents, Buffers, Valves, Guages, Seals), Accessories, ... - Forecasts to 2019” provides a detailed overview ... market trends, and strategies impacting the preparative and ...
(Date:12/24/2014)... Boston, MA (PRWEB) December 23, 2014 Earlier ... James L. Sherley, director of the Adult Stem Cell Technology ... overlooked and under appreciated unique property of adult tissue stem ... Misunderstood in the Past, Important for the Future,” embodied the ...
(Date:12/24/2014)... On Friday, December 19, 2014, President Obama signed ... Appropriations Act of 2015, which for the first time, ... the Congressionally Directed Medical Research Programs (CDMRP) administered by ... working in conjunction with its allies on Capitol Hill, ...
Breaking Biology Technology:Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2
... PRINCETON, N.J., May 26 Medarex, Inc. (Nasdaq: ... live webcast at 4:00 p.m. Eastern Time on Tuesday, June ... Product Development at Medarex will provide an update and recent ... archive can be accessed through the Investor Relations section of ...
... announces it is developing a novel technology that can ... but can also be used in a wide range ... art, currency, electronic components, high value added ingredients, to ... go to: http://www.prnewswire.com/mnr/trutag/38547/ (Photo: ...
... 26 Vaxart, Inc., a biotechnology company focused on ... company has created a candidate vaccine for H1N1 influenza ... for immune responses in animals, just 25 days after ... the research-grade H1N1 vaccine to its successful avian flu ...
Cached Biology Technology:Medarex to Host Clinical Program Update Conference Call on Tuesday, June 2, 2009 2Photos: Breakthrough Technology Enables Edible TruTag(TM) to Prevent Counterfeit Medicine 2Photos: Breakthrough Technology Enables Edible TruTag(TM) to Prevent Counterfeit Medicine 3Vaxart Begins Animal Testing of H1N1 Flu Vaccine Candidate 2
... The wide and long ... of Polaroid gel documentation systems. ... holds the camera in place ... that allows photography on the ...
... tissue microarrays are derived from Paraffin embedded ... quality control procedures to ensure the highest ... assembled in one block, sectioned at a ... coated slides. Sections are large (3-5 mm ...
... Zyagen tissue microarrays are derived from ... to rigorous quality control procedures to ensure ... are manually assembled in one block, sectioned ... on coated slides. Sections are large (3-5mm ...
... is used for single-color real-time detection using ... JOE fluorophores and features a real-time PCR ... from 96 wells, a gene expression macro ... The system includes the optical module and ...
Biology Products: