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MIT sculpts 3-D particles with light
Date:12/3/2007

ed last year by Doyle and his students. The second mask, which is based on MIT professor Edwin Thomas' work in multibeam lithography, adds three-dimensional texture and other physical traits, such as porosity.

The collaboration sprung from a conversation between Ji-Hyun Jang, a postdoctoral associate in Thomas' lab, and Dhananjay Dendukuri, a recent Ph.D. recipient in Doyle's lab, who are also authors on the paper.

It's very easy to integrate the (second) phase mask into the microfluidic apparatus, said Thomas, Morris Cohen Professor of Materials Science and Engineering and head of the Department of Materials Science and Engineering. Professor Doyle was controlling the overall shape, and now what we're doing is controlling these inner labyrinth networks.

Adding inner texture is desirable because it increases the particles' surface-to-volume ratio, which means if the particle is loaded with probes, there are more potential binding sites for target molecules.

In a paper published in Science earlier this year, Doyle and MIT graduate student Daniel Pregibon showed that the particles can be used as probes to identify DNA and other molecules.

Other applications for the particles include tissue engineering. For example, they could form a scaffold that would both provide structural support for growing cells and release growth factors and other nutrients. The particles can be designed so diffusion occurs in a particular direction, allowing researchers to control the direction of nutrient flow.


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Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
Source:Eurekalert

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