Navigation Links
MIT researchers develop a better way to see molecules at work in living brain cells
Date:10/7/2010

CAMBRIDGE, Mass. -- By creating a better way to see molecules at work in living brain cells, researchers affiliated with MIT's Picower Institute for Learning and Memory and the MIT Department of Chemistry are helping elucidate molecular mechanisms of synapse formation. These studies could also help further understanding of how synapses go awry in developmental diseases such as autism and Fragile X syndrome. The study will appear in the Oct. 7 issue of Cell.

Using the new technique, which is more accurate and sensitive than existing methods, the researchers found that certain protein-protein interactions can affect early phases of synapse maturation. Their work will help scientists understand exactly how two adjacent neurons form a synapsethe meeting point where information transfer among brain cells occurs. This method provides information on the dynamics of proteins in synapses on a minute-by-minute time scale, the researchers said.

"How nascent contacts mature into excitatory or inhibitory synapses is an area of intense interest," said Amar Thyagarajan, Autism Speaks Postdoctoral Fellow in the laboratory of Alice Y. Ting, associate professor of chemistry. "Trans-synaptic signaling complexes seem like a good place to start looking for clues to this process since they mediate signaling into the pre- and post-synaptic cells during this process."

Study co-authors Thyagarajan and Ting are Picower Institute affiliates.

The researchers studied the interaction of the proteins neurexin and neuroligin on the surface of neurons. These adhesion molecules--two of many in the brain that regulate synapse formation, maturation, function and plasticity--not only function as the "glue" that hold neurons together but also mediate signaling so that the appropriate molecular components are recruited for the pre- and postsynaptic cells.

Neurexins and neuroligins can be thought of as a chemical bridge and communication network
'/>"/>

Contact: Jennifer Hirsch
jfhirsch@mit.edu
617-253-1682
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... /PRNewswire/ - Today, FindBiometrics, the leading source of biometrics industry news, ... website design. "When we launched FindBiometrics 12 years ... O,Neill , founder and CEO of FindBiometrics. "Now it,s maturing ... the key players on a very broad scale.  We are ...
(Date:1/22/2015)... Wis. , Jan. 15, 2015  BellBrook Labs, ... drug discovery, announced the launch of a TR-FRET ... the company,s Transcreener UDP Assay, a high throughput ... The new assay will allow for sensitive detection ...
(Date:1/22/2015)... POINT ROBERTS, Washington , January 20, 2015 ... sectors including technology and tech stocks, releases video from the ... pickpocket and security consultant Apollo Robbins . ... about the Wocket™ biometric smart wallet, a product of NXT-ID, ...
Breaking Biology News(10 mins):Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3
... marrow that can continuously make red and white blood ... lab. This development could lead to simpler ... and a continuous supply of blood for transfusions. ... the tissues supporting bone marrow in the body, said ...
... has been awarded the distinction of Fellow in the ... to the field of microbial genomics and ecology, particularly ... technologies. Election as a Fellow is an ... is a presidential professor in OU,s Department of Botany ...
... of socioeconomic status and children,s educational environment. Nevertheless, ... spite of high parental education and support for ... Boulder psychologists Angela Friend, John C. DeFries and ... influences on reading disability, the most commonly identified ...
Cached Biology News:Biomedical researchers create artificial human bone marrow in a test tube 2University of Oklahoma researcher named 2008 AAAS Fellow 2The effect of parental education on the heritability of children's reading disability 2
(Date:3/4/2015)... -- Launched by the Assistance Publique ... December 2011, ,SARAH, - the French national collaborative ... in advanced hepatocellular carcinoma (HCC) has enrolled more than ... SARAH, a large French study of patients with advanced, ... completed patient enrolment, exceeding its 400-patient target, according to ...
(Date:3/3/2015)... WASHINGTON , March 3, 2015 NASA astronaut ... his launch this month to spend a year living and ... live satellite interviews from 5:30 to 7 a.m. EDT Monday, ... Moscow as he completes the final weeks of ... by a video on NASA Television highlighting his mission training ...
(Date:3/3/2015)... March 3, 2015 /CNW/- SQI Diagnostics Inc. (TSX:V: SQD), ... technologies and products for advanced microarray diagnostics, today ... CFE  to its Management team. In his capacity ... its transition from a development stage to a ... advance the Company,s capital market strategy and to ...
(Date:3/3/2015)... NEW YORK , March 3, 2015 ... that Jeffrey I.D. Lewis has joined the ... Practice, resident in the New York ... also handles trademark matters, as well as other intellectual ... registered patent attorney, Mr. Lewis represents both plaintiffs and ...
Breaking Biology Technology:Treatment of Primary Liver Cancer: SARAH Study Completes Enrolment, Results Expected Late 2016 2Treatment of Primary Liver Cancer: SARAH Study Completes Enrolment, Results Expected Late 2016 3Treatment of Primary Liver Cancer: SARAH Study Completes Enrolment, Results Expected Late 2016 4Treatment of Primary Liver Cancer: SARAH Study Completes Enrolment, Results Expected Late 2016 5NASA Astronaut Scott Kelly Available for Interviews before One-Year Space Station Mission 2SQI Diagnostics Appoints Chief Financial Officer 2SQI Diagnostics Appoints Chief Financial Officer 3Leading Patent Attorney Jeffrey Lewis Joins Fried Frank's Intellectual Property Litigation Practice 2Leading Patent Attorney Jeffrey Lewis Joins Fried Frank's Intellectual Property Litigation Practice 3
... and KARLSRUHE, Germany , June 16, 2010 ,The medical devices company ... "Growth requires space" had already been the motto of,the last company move back in ... The US market ... Campbell to Irvine, California , one,of high-tech industry centers in ...
... of researchers to examine biological specimens, enabling a ... in X-ray diffraction methods have helped extend the ... significant progress has been made in optical microscopy ... on fluorescent labeling technologies, which prohibit the quantitative ...
... N.M. The world,s smallest chess board about ... pea-sized microbarbershop were winners in this year,s design contest ... at Sandia National Laboratories in mid May. The ... Sandia,s microfabrication facility, one of the most advanced in ...
Cached Biology Technology:joimax(R) Moves Into Larger Premises 2Researchers use X-ray diffraction microscope to reveal 3-D internal structure of whole cell 2Researchers use X-ray diffraction microscope to reveal 3-D internal structure of whole cell 3Texas Tech, U of Utah win Sandia microdevice competition 2Texas Tech, U of Utah win Sandia microdevice competition 3Texas Tech, U of Utah win Sandia microdevice competition 4
Applications: Beadlyte® assay Stability: 2 years at 4°C (lyophilized) or 6 months at -20°C (rehydrated) ...
Human acetylcholine receptor (AChR)-alpha. Exhibits homogenous, high affinity,binding to the receptor. Binds weakly to a64-78. Inhibits binding of many,myasthenia gravis sera to human AChR....
Dnase and Rnase free...
...
Biology Products: