Navigation Links
MIT model could improve some drugs' effectiveness
Date:9/23/2007

CAMBRIDGE, MA--MIT researchers have developed a computer modeling approach that could improve a class of drugs based on antibodies, molecules key to the immune system. The model can predict structural changes in an antibody that will improve its effectiveness.

The team has already used the model to create a new version of cetuximab, a drug commonly used to treat colorectal cancer, that binds to its target with 10 times greater affinity than the original molecule.

The work, which will appear Sept. 23 in an advance publication of Nature Biotechnology, results from a collaboration using both laboratory experiments and computer simulations, between MIT Professors Dane Wittrup and Bruce Tidor.

New and better methods for improving antibody development represent critical technologies for medicine and biotechnology, says Wittrup, who holds appointments in MIT's Department of Biological Engineering and Department of Chemical Engineering. Tidor holds appointments in Biological Engineering and the Department of Electrical Engineering and Computer Science.

Antibodies, which are part of nature's own defense system against pathogens, are often used for diagnostics and therapeutics. Starting with a specific antibody, the MIT model looks at many possible amino-acid substitutions that could occur in the antibody. It then calculates which substitutions would result in a structure that would form a stronger interaction with the target.

Combining information about protein (antibody) structure with calculations that address the underlying atomic interactions allows us to make rational choices about which changes should be made to a protein to improve its function, said Shaun Lippow, lead author of the Nature Biotechnology paper.

Protein modeling can reduce the cost of developing antibody-based drugs, Lippow added, as well as enable the design of additional protein-based products such as enzymes for the conversion of biomas
'/>"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study Models Impact Of Anthrax Vaccine
2. Scientists identify new model Of NK cell development
3. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
4. Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
5. Molecular models advance the fight against malaria
6. NYU and MSKCC research provides model for understanding chemically induced cancer initiation
7. Genetic therapy reverses nervous system damage in animal model of inherited human disease
8. Disease progression model of pancreatic cancer developed by Penn researchers
9. A new way to share models of biological systems
10. Understanding biases in epidemic models important when making public health predictions
11. Climate model links higher temperatures to prehistoric extinction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/12/2015)... 2015  New research unveiled at Black Hat ... to steal users, fingerprints. Information released today by ... scanners on mobile devices, making the security of ... on mobile devices, HYPR Corp. recently released a ... systems with strong cryptographic security. More information on ...
(Date:8/6/2015)... Calif. , Aug. 6, 2015  Today, ... will visit Crossmatch ™ to learn firsthand ... and protect data. Crossmatch is a world leader ... technologies and expertise are helping federal agencies and ... and security.   "The vast majority ...
(Date:8/5/2015)... , Aug. 5, 2015 The biosensors market ... in applications, penetration into newer sectors, and development of ... global biosensors space has seen the entry of multiple ... so far. (Photo - http://photos.prnewswire.com/prnh/20150805/255570 ) ... Analysis of the Global Biosensors Market ( ...
Breaking Biology News(10 mins):HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3Rep. Honda to Visit Crossmatch in Redwood City 2Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4
... wheat ( Triticum aestivum ) is one of the "big ... consumed by people. Fully 35% of the world,s 7 billion ... international team of scientists, including a group from Cold Spring ... its full genome. The study reveals the evolution ...
... a surprise to hear that most adult entertainment club workers ... bartenders, waitresses and hostesses don,t have great medical benefits. ... repeated unwanted sexual advances and behavior. Add in the prevalence ... a perfect storm for unchecked health risks. To ...
... unique aroma signature of the durian revered as the ... the world,s foulest smelling food has uncovered several new ... ACS, Journal of Agricultural and Food Chemistry . ... food shops in the United States and elsewhere, has a ...
Cached Biology News:Bread wheat's large and complex genome is revealed 2Bread wheat's large and complex genome is revealed 3Rhode Island Hospital: Adult entertainment workers likely to benefit from health care intervention 2
(Date:8/31/2015)... ... August 31, 2015 , ... ... of its properties such as low carbon footprints and compostability. These properties can ... petroleum based plastics. On the basis of applications, the market for biodegradable plastics ...
(Date:8/31/2015)... Aug. 31, 2015 Research and Markets ( ... "Argentina Biomedical Sensors Market - Growth, Trends & Forecasts ... The Argentina Biomedical Sensors market is estimated at $0.17 ... the period 2014-2020 The near future will ... formulation of each individual. These sensors can be set ...
(Date:8/31/2015)... DUBLIN , Aug. 31, 2015 Research ... of the "Israel Biomedical Sensors Market - Growth, ... The Israel Biomedical Sensors market is ... of 3.73% over the period 2014-2020 The ... to the genetic formulation of each individual. These sensors ...
(Date:8/31/2015)... BALTIMORE , Aug. 31, 2015  For people ... may brighten their day. The biotechnology company, located in ... outlined one of the best potential therapies yet for ... paper entitled, " Correction of Down syndrome and Edwards ... the journal DNA Research . Elixirgen plans to ...
Breaking Biology Technology:Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 2Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 3Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 4Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 5Argentina Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts 2014-2020 2Israel Biomedical Sensors Market 2015 - Growth, Trends & Forecasts to 2020 2New Down syndrome therapy discovered 2
... Sept. 17 Synvista,Therapeutics, Inc. (Amex: SYI ) ... to the Company,s Web site http://www.synvista.com . The,text ... team at Synvista Therapeutics has made tremendous progress in ... and to redefine,the treatment of cardiovascular disease in diabetics ...
... Sigma-Aldrich Corporation,(Nasdaq: SIAL ) will be presenting ... September 24th at 8:30 AM ET at the Grand ... live audio broadcast over the,Internet available at http://ir.sigmaaldrich.com ... file. For the webcast on, http://ir.sigmaaldrich.com users will ...
... Alfacell Corporation,(Nasdaq: ACEL ) announced today ... of Oppenheimer & Co. as a financial advisor ... alternatives to enhance,shareholder value, including a possible sale ... not be limited to, strategic partnership,transactions., "Alfacell ...
Cached Biology Technology:Synvista Therapeutics Posts Letter to Stockholders on Web Site 2Synvista Therapeutics Posts Letter to Stockholders on Web Site 3Synvista Therapeutics Posts Letter to Stockholders on Web Site 4Synvista Therapeutics Posts Letter to Stockholders on Web Site 5Synvista Therapeutics Posts Letter to Stockholders on Web Site 6Alfacell Hires Advisors to Advance Strategic Alternatives 2Alfacell Hires Advisors to Advance Strategic Alternatives 3
Human Cell Line Slides...
... 2 Detection System combines the indirect ... principle and Signets unique formulation of ... and reliablility. Signet reagents will achieve ... and automated protocols. ,Signets USA Detection ...
... Level 2 Detection System combines the ... bonding principle and Signets unique formulation ... specificity and reliablility. Signet reagents will ... manual and automated protocols. ,Signets ...
Ideally suited for resolving DNA and RNA 10-1000 bases especially PCR products ranging from 100-1000 bp. Gelling temp. (4%) 27C Melting temperature 65C. EEO: 0.10 Rnase/Dnase: none detected...
Biology Products: