Navigation Links
MIT links gene to cholesterol
Date:10/11/2007

CAMBRIDGE, MA--MIT researchers have discovered a link between a gene believed to promote long lifespan and a pathway that flushes cholesterol from the body.

The finding could help researchers create drugs that lower the risk of diseases associated with high cholesterol, including atherosclerosis (clogged arteries) and Alzheimer's disease.

The study focused on a gene called SIRT1, which the researchers found prevents cholesterol buildup by activating a cellular pathway that expels cholesterol from the body via HDL (high density lipoprotein or good cholesterol).

SIRT1 is an important mediator of cholesterol efflux, and as such it's predicted to play a role in the development of age-associated diseases where cholesterol is a contributing factor, said Leonard Guarente, MIT professor of biology and senior author of a paper on the work to be published in the Oct. 12 issue of Molecular Cell.

Drugs that enhance the effects of SIRT1 could lower the risk of cholesterol-related diseases, Guarente said. Potential drugs could be based on polyphenols, which are found in red wine and have been shown to enhance SIRT1. However, the quantities naturally found in red wine are not large enough to have a significant impact on cholesterol levels.

In earlier studies, Guarente has shown that high levels of SIRT1 can be achieved with extreme calorie restriction, but that is unappealing for most people.

If you had a drug that could increase expression of SIRT1, that could replicate the effects of calorie restriction, Guarente said. This is not going to replace the need for a healthy lifestyle, but it's a supplement that could potentially make you healthier.

SIRT1 is the mammalian homologue to SIR2, a gene that has been shown to slow aging in yeast and roundworms. Researchers have been curious to find out whether SIRT1 has similar effects.

In the new MIT study, researchers found that low SIRT1 levels in mice lead to cholesterol buildup in cells such as macrophages, a type of immune cell, due to reduced activity of a protein called LXR (liver X receptor).

LXR is responsible for transporting cholesterol out of macrophage cells. When full of cholesterol, the macrophages can generate plaques that clog arteries. SIRT1 boosts LXR activity, so that cholesterol is expelled from macrophages and out of the body by HDL.


'/>"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
Source:Eurekalert

Related biology news :

1. Study Links Ebola Outbreaks To Animal Carcasses
2. NASA links nanobacteria to kidney stones and other diseases
3. Insight into DNAs weakest links may yield clues to cancer biology
4. One gene links newborn neurons with those that die in diseases such as Alzheimers
5. Genetic links could unlock clues to leading cause of blindness
6. Climate model links higher temperatures to prehistoric extinction
7. Genetics links whale to two different ocean basins
8. Scientists discover a genetic switch that links animal growth and cancer
9. Hap1 protein links circulating insulin to brain circuits that regulate feeding behavior in mice
10. Imaging study links key genetic risk for Alzheimers disease to myelin breakdown
11. Queensland scientists identify molecule that links both sides of the brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... SANTA MONICA, Calif. , April 13, 2017 /PRNewswire/ ... New York will feature emerging and ... Innovation Summits. Both Innovation Summits will run alongside the ... variety of speaker sessions, panels and demonstrations focused on ... east coast,s largest advanced design and manufacturing event will ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
(Date:4/5/2017)... 2017 Today HYPR Corp. , leading ... component of the HYPR platform is officially FIDO® ... security architecture that empowers biometric authentication across Fortune 500 ... secured over 15 million users across the financial services ... home product suites and physical access represent a growing ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology today ... designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) ... able to cross the cell membrane and bind intracellular STAT3 and inhibit its ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO of ... Club. The event entitled “Stem Cells and Their Regenerative Powers,” was ... Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. Hanson, M.D., ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program ... honoring scientists who have made outstanding contributions to analytical chemistry and ... 2018, the world’s leading conference and exposition for laboratory science, which will be ...
(Date:10/9/2017)... ... October 09, 2017 , ... The Giving Tree Wellness Center ... the needs of consumers who are incorporating medical marijuana into their wellness and ... , As operators of two successful Valley dispensaries, The Giving Tree’s two founders, ...
Breaking Biology Technology: