Navigation Links
MIT links gene to cholesterol
Date:10/11/2007

CAMBRIDGE, MA--MIT researchers have discovered a link between a gene believed to promote long lifespan and a pathway that flushes cholesterol from the body.

The finding could help researchers create drugs that lower the risk of diseases associated with high cholesterol, including atherosclerosis (clogged arteries) and Alzheimer's disease.

The study focused on a gene called SIRT1, which the researchers found prevents cholesterol buildup by activating a cellular pathway that expels cholesterol from the body via HDL (high density lipoprotein or good cholesterol).

SIRT1 is an important mediator of cholesterol efflux, and as such it's predicted to play a role in the development of age-associated diseases where cholesterol is a contributing factor, said Leonard Guarente, MIT professor of biology and senior author of a paper on the work to be published in the Oct. 12 issue of Molecular Cell.

Drugs that enhance the effects of SIRT1 could lower the risk of cholesterol-related diseases, Guarente said. Potential drugs could be based on polyphenols, which are found in red wine and have been shown to enhance SIRT1. However, the quantities naturally found in red wine are not large enough to have a significant impact on cholesterol levels.

In earlier studies, Guarente has shown that high levels of SIRT1 can be achieved with extreme calorie restriction, but that is unappealing for most people.

If you had a drug that could increase expression of SIRT1, that could replicate the effects of calorie restriction, Guarente said. This is not going to replace the need for a healthy lifestyle, but it's a supplement that could potentially make you healthier.

SIRT1 is the mammalian homologue to SIR2, a gene that has been shown to slow aging in yeast and roundworms. Researchers have been curious to find out whether SIRT1 has similar effects.

In the new MIT study, researchers found that low SIRT1 levels in mice lead to cholesterol buildup in cells such as macrophages, a type of immune cell, due to reduced activity of a protein called LXR (liver X receptor).

LXR is responsible for transporting cholesterol out of macrophage cells. When full of cholesterol, the macrophages can generate plaques that clog arteries. SIRT1 boosts LXR activity, so that cholesterol is expelled from macrophages and out of the body by HDL.


'/>"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
Source:Eurekalert

Related biology news :

1. Study Links Ebola Outbreaks To Animal Carcasses
2. NASA links nanobacteria to kidney stones and other diseases
3. Insight into DNAs weakest links may yield clues to cancer biology
4. One gene links newborn neurons with those that die in diseases such as Alzheimers
5. Genetic links could unlock clues to leading cause of blindness
6. Climate model links higher temperatures to prehistoric extinction
7. Genetics links whale to two different ocean basins
8. Scientists discover a genetic switch that links animal growth and cancer
9. Hap1 protein links circulating insulin to brain circuits that regulate feeding behavior in mice
10. Imaging study links key genetic risk for Alzheimers disease to myelin breakdown
11. Queensland scientists identify molecule that links both sides of the brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/3/2017)... WASHINGTON , April 3, 2017 /PRNewswire-USNewswire/ ... single-cell precision engineering platform, detected a statistically ... cell product prior to treatment and objective ... highlight the potential to predict whether cancer ... prior to treatment, as well as to ...
(Date:3/29/2017)... , March 29, 2017  higi, the health IT ... North America , today announced a ... the acquisition of EveryMove. The new investment and acquisition ... of tools to transform population health activities through the ... data. higi collects and secures data today ...
(Date:3/24/2017)... -- Research and Markets has announced the addition of ... - Industry Forecast to 2025" report to their offering. ... The Global Biometric Vehicle ... around 15.1% over the next decade to reach approximately $1,580 million ... estimates and forecasts for all the given segments on global as ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... At its ... announced Dr. Suneel I. Sheikh, the co-founder, CEO and chief research scientist of ... been selected for membership in ARCS Alumni Hall of Fame . ASTER ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/10/2017)... CALIF. (PRWEB) , ... October 10, 2017 , ... San ... part of its corporate rebranding initiative announced today. The bold new look is ... reach, as the company moves into a significant growth period. , It will also ...
(Date:10/10/2017)... SomaGenics announced the receipt of a Phase ... (Single Cell), expected to be the first commercially available ... from single cells using NGS methods. The NIH,s recent ... development of approaches to analyze the heterogeneity of cell ... for measuring levels of mRNAs in individual cells have ...
Breaking Biology Technology: