Navigation Links
MIT-led teams unravel heparin death mystery
Date:4/23/2008

CAMBRIDGE, Mass.--An international team of researchers led by MIT has explained how contaminated batches of the blood-thinner heparin were able to slip past traditional safety screens and kill dozens of patients recently in the United States and Germany.

The team, led by Professor Ram Sasisekharan of MIT, identified the chemical structure of the contaminant, known as oversulfated chondroitin sulfate (OSCS). The researchers present their findings and offer new approaches to detecting the contaminant in a report appearing today in the online edition of Nature Biotechnology.

Another team led by Sasisekharan has shown exactly how OSCS can kill-specifically by setting off an allergy-like reaction. The biological effects of the contaminant are outlined in a report also being published online today in the New England Journal of Medicine.

Sophisticated analytical techniques enabled complete characterization of the contaminant present in heparin. Further, this study also provides the scientific groundwork for critical improvements in screening practices that can now be applied to monitor heparin, thus ensuring patient safety, said Sasisekharan, senior author of the papers and the Underwood Prescott Professor of Biological Engineering and Health Sciences and Technology at MIT.

Heparin, a blood thinner often used during kidney dialysis or heart surgery, is normally produced from pig intestines. FDA officials say the contaminated heparin came from factories in China that manufacture the drug for Baxter International.

Baxter recalled its heparin in February after dozens of deaths were reported, dating back to November. The tainted heparin has been blamed for 81 U.S. deaths so far, and earlier this week, the FDA announced that contaminated batches were also found in 10 other countries.

The New England Journal of Medicine study offers the first potential link between the contaminant and the reported deaths. The researcher
'/>"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Singulex Teams With Wyeth Pharmaceuticals to Translate Pre-Clinical Biomarker Research Into Clinical Study Design
2. Pew Institute teams with Chantecaille Cosmetics to protect global marine life
3. Unravelling new complexity in the genome
4. MIT unraveling secrets of red tide
5. Scientists unravel plants natural defenses
6. Rebuilding the evolutionary history of HIV-1 unravels a complex loop
7. Unravelling the Northwests Viking past
8. Scientists unravel the genetic coding of the pea
9. Honeybee researcher to unravel properties governing lifespan with support from Norway
10. Computation to unravel how genes are regulated and shed light on how cells become different
11. Bleeding, not inflammation, is major cause of early lung infection death
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2015)... , Apr. 6, 2015 NXT-ID, Inc. ... a biometric authentication company focused on the growing ... filed provisional patent 62/143028 for MINIATURE, ... ENERGY TRANSFER  NXT-ID introduces a new ... This patent surrounds the use of miniature antenna ...
(Date:4/1/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... mobile commerce market, announces the second shipment of a ... early access pre-order customers. Feedback from ... including Walmart, Target, AT&T, Dunkin, Donuts, Stop & Shop ... all outlets and very easy to use. Several users ...
(Date:3/26/2015)... TORONTO , March 26, 2015 ... premier family, social, recreation and athletic club, today announced ... designed to allow freedom of movement for members and ... "Following a comprehensive process, we selected FST,s IMID ... sophistication and convenience for our members and staff, in ...
Breaking Biology News(10 mins):NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2
... This release is available in Spanish . ... ruminants ward off damaging gastrointestinal nematodes that can cause illness ... Animal scientist Joan Burke at the ARS Dale Bumpers Small ... several universities, has patented formulations of Sericea lespedeza , ...
... lizards supports an old idea about how species can ... and biologists have speculated that these "morphs" could be ... types of individuals within the same population could eventually ... conducted by researchers at the University of California, Santa ...
... perceive even the slightest vibration and touch of the ... the mediation of these sensations. Ion channels are pores ... external signals. Mechanosensitive ion channels open at the slightest ... the cell membrane, which causes an electrical current until ...
Cached Biology News:Forage plant wards off ruminant gastrointestinal nematode 2Evolutionary game of rock-paper-scissors may lead to new species 2Evolutionary game of rock-paper-scissors may lead to new species 3Evolutionary game of rock-paper-scissors may lead to new species 4MDC researchers link protein tether to touch perception 2
(Date:4/30/2015)... The following is an open letter sent April ... Blood Corp (NYSE: CO ) from Jayhawk Capital. ... directors of China Cord Blood Corp (" China Cord ") ... share from Golden Meditech Holdings Co Ltd ("Golden Med"). Certainly, ... benefit Golden Med and Mr. Kam, the Chairman of both ...
(Date:4/30/2015)...  The Paul G. Allen Family Foundation announced today ... six groups of researchers with projects at the frontier ... growing mature human brain cells in the laboratory. The ... over three years.  "This new cohort ... significant because the field of neuronal maturation is at ...
(Date:4/30/2015)... Calif. , April 30, 2015  Asterias Biotherapeutics, ... the emerging field of regenerative medicine, today announced that ... on Thursday, May 7, 2015 after the close of ... conference call and webcast on Thursday, May 7, 2015 ... discuss the results and recent corporate developments. ...
(Date:4/30/2015)... WuXi PharmaTech (Cayman) Inc. ("WuXi" or the "Company") (NYSE: ... provider, today announced that its board of directors has ... 2015, from a consortium (the "Consortium") led by Dr. ... chief executive officer of the Company, and Ally Bridge ... "Transaction") involving the acquisition of all outstanding shares of ...
Breaking Biology Technology:April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 2April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 3April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 4April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 5The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 2The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 3The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 4The Paul G. Allen Family Foundation Awards $7.5 Million To Study Brain Cell Growth And Development 5Asterias Biotherapeutics to Report First Quarter Results on May 7, 2015 2Asterias Biotherapeutics to Report First Quarter Results on May 7, 2015 3WuXi PharmaTech Announces Receipt of Proposal 2WuXi PharmaTech Announces Receipt of Proposal 3WuXi PharmaTech Announces Receipt of Proposal 4WuXi PharmaTech Announces Receipt of Proposal 5WuXi PharmaTech Announces Receipt of Proposal 6
... REDWOOD CITY, Calif., Sept. 15 Cardica, Inc.,(Nasdaq: ... million milestone,payment from Cook Medical (Cook) for the successful ... in the heart known as,patent foramen ovales (PFO), a ... of the general population., "Patients with PFO may ...
... China Biopharma,Inc. (OTC Bulletin Board: CBPC) announced today that ... State of Delaware an amendment to its Certificate,of Incorporation ... China,Biopharma,s common stock ("Common Stock") will begin trading on ... symbol CHBO., By unanimous written consent dated July ...
... /Xinhua-PRNewswire/ -- Sinovac Biotech Ltd. (Amex:,SVA), a leading ... of clinical trials in Ukraine for its inactivated ... are being conducted by,Biolik Biopharmaceutical Company, a vaccine ... in the Country. Biolik will,also market and distribute ...
Cached Biology Technology:Cardica Receives $1 Million Milestone Payment From Cook Medical for Development of Heart Defect Closure Device 2Cardica Receives $1 Million Milestone Payment From Cook Medical for Development of Heart Defect Closure Device 3Cardica Receives $1 Million Milestone Payment From Cook Medical for Development of Heart Defect Closure Device 4China Biopharma Effects 1 for 100 Reverse Stock Split 2China Biopharma Effects 1 for 100 Reverse Stock Split 3Sinovac Initiates Clinical Trials for Inactivated Hepatitis A Vaccine in Ukraine 2Sinovac Initiates Clinical Trials for Inactivated Hepatitis A Vaccine in Ukraine 3