Navigation Links
MIT finds key to avian flu in humans
Date:1/6/2008

CAMBRIDGE, Mass.--MIT researchers have uncovered a critical difference between flu viruses that infect birds and humans, a discovery that could help scientists monitor the evolution of avian flu strains and aid in the development of vaccines against a deadly flu pandemic.

The researchers found that a virus's ability to infect humans depends on whether it can bind to one specific shape of receptor on the surface of human respiratory cells.

Now that we know what to look for, this could help us not only monitor the bird flu virus, but it can aid in the development of potentially improved therapeutic interventions for both avian and seasonal flu, said Ram Sasisekharan, MIT Underwood Prescott Professor of Biological Engineering and Health Sciences and Technology, and the senior author of a paper on the work that will appear in the Jan. 6 issue of Nature Biotechnology.

Flu viruses come in many strains, and not all of them can infect humans. Strains known as H1 or H3 have jumped from birds to humans and hence are tailored to attack cells of the human upper respiratory tract. H5 strains are usually confined to birds, but when they do infect humans they can have very high fatality rates.

In the past decade, isolated outbreaks of avian flu (H5N1) in humans have raised concerns that a deadly pandemic could arise if the avian flu evolves to a form that can easily infect humans and pass from person to person. Some scientists believe such an outbreak could rival the 1918 Spanish flu that killed 50 million to 100 million people worldwide.

Scientists already knew that whether an influenza virus infects humans depends on whether its hemagglutinin, a protein found on the virus surface, can bind to sugar (or glycan) receptors in the respiratory tract. Human respiratory cells have glycan receptors classified as alpha 2-6; avian respiratory cells' glycan receptors are known as alpha 2-3. This classification is based on how the sugars are
'/>"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New report finds great potential for Swedish medical technology
2. Threatened bird species finds home at Western
3. Brain-computer link systems on the brink of breakthrough, study finds
4. RAND study finds evidence disease management programs
5. Study finds first-ever genetic animal model of autism
6. New study finds biodiversity conservation secures ecosystem services for people
7. Wildlife Conservation Society study finds seasonal seas save corals with tough love
8. Study of malaria parasite in patient blood finds distinct physiological states
9. New test finds diisobutyl phthalate in some cardboard food packaging -- recycling is the issue
10. Evolutionary comparison finds new human genes
11. Baker Institute finds increased domestic production wont make US self-sufficient in natural gas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/10/2015)... BOULDER, Colo. , March 10, 2015 ... Space Flight "Personalized Medicine in Human ... Ph.D. and Thomas J. Goodwin , Ph.D. was ... articles of the past two years. Specifically, ... three most downloaded scientific papers published in 2013 and ...
(Date:3/5/2015)... , March 5, 2015 In Brazil ... of companies already using these solutions and 42 percent planning ... the latter, approximately 25 percent of the companies will be ... While the majority of companies in the region are currently ... the hybrid model will command significant attention in the coming ...
(Date:3/2/2015)... 2, 2015 Synaptics Inc. (NASDAQ: ... interface solutions, today announced a new implementation of ... enable rapid and secure transactions and reliable identification ... is a turnkey solution providing mouse and keyboard ... integrate fingerprint ID solutions into their product offerings, ...
Breaking Biology News(10 mins):"Personalized Medicine in Human Space Flight" Listed Among Most Influential Papers of 2013 and 2014 2Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 2Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 3Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 4Synaptics Unveils New Fingerprint ID Solution for Gamers 2Synaptics Unveils New Fingerprint ID Solution for Gamers 3
... VTT Technical Research Centre of Finland indicates that there is ... sold in Finland as regards fuel consumption in normal driving. ... using six used cars of different make under laboratory conditions. ... fuel consumption is significantly higher with 95E10 petrol than with ...
... A group of scientists at the Instituto Gulbenkian de Cincia, ... skeleton and organ size. The team, led by Florence Janody, ... the proteins that regulates the skeleton of the cell also ... and proliferation. Their findings have implications for cancer research, as ...
... organ in the human body that metabolizes foreign compounds such ... liver as an alarm system, researchers are starting to better ... their effects on the human body. One ... the Virginia Tech Institute of Critical Technology and Applied Science,s ...
Cached Biology News:VTT: No significant difference in car fuel consumption between E10 and E5 petrol grades 2Scientists uncover role for cell scaffold in tumor formation 2Engineered liver may shed light on effects of chemicals in the environment 2
(Date:3/26/2015)... , March 26, 2015 PAREXEL ... global clinical research organization , announced ... definitive agreement to acquire all of the ... a leading provider of specialized pharmacovigilance services, ... the collection, detection, assessment, monitoring, and prevention ...
(Date:3/26/2015)... 2015 WriteResult, a premier provider of ... Yale University’s School of Public Health and New Haven ... a 4 month-long project. The goal of the study ... families with free access to fresh produce and nutrition ... concerns like high blood pressure, diabetes and weight gain. ...
(Date:3/25/2015)... 2015 Optimal Research, LLC has been nominated ... Award "Best Clinical Site or Trial Network". ... been selected as a nominee in this ViE award ... Recommended" distinction in 2014. The ViE awards were created ... and positive contributions of companies and individuals in the ...
(Date:3/25/2015)... Accelovance, a therapeutically focused contract research organization ... Research Organization" at the upcoming Vaccine Industry Excellence (ViE) ... This is the eighth consecutive year Accelovance has ... for "Best Contract Research Organization" in 2009, 2010, and ... "We,re excited to be a finalist for ...
Breaking Biology Technology:PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 3PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 4Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 2Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 3Optimal Research Nominated 2015 Vaccine Industry Excellence (ViE) Award 2Accelovance Nominated for 2015 Vaccine Industry Excellence (ViE) Awards 2
... June 25 BioNeutral announced today that,Steve Browand ... advanced,chemical technology products to the military, Homeland Security ... the test,results announced by Dr. Tierno, regarding anthrax, ... Tierno and the performance of the,company,s formulations in ...
... ingredient, GanedenBC30, to power new raisin bran probiotic muffins. , ... ... Street Gourmet, one of the fastest growing manufacturers of gourmet frozen ... fortified with the high-survivability probiotic, GanedenBC30 (Bacillus coagulans GBI-30, ...
... CLAREMONT, Calif., June 25 /Xinhua-PRNewswire-FirstCall/ --,Kiwa Bio-Tech ... that on June 23rd, 2008, Kiwa Bio-Tech ... documents from the Ministry of,Commerce of the ... to,wholesale other companies, fertilizer products, including chemical,fertilizers, ...
Cached Biology Technology:BioNeutral Laboratories Announces the Appointment of Stephen Browand as a Director to Head Military, Homeland Security and Governmental Affairs 2Main Street Gourmet Launches New Probiotic Muffins 2Main Street Gourmet Launches New Probiotic Muffins 3Kiwa Bio-Tech Receives Authorization From the Ministry of Commerce of the People's Republic of China to Wholesale Other Fertilizer Manufacturers Products 2Kiwa Bio-Tech Receives Authorization From the Ministry of Commerce of the People's Republic of China to Wholesale Other Fertilizer Manufacturers Products 3
Without sodium bicarbonate. Sterile, Cell culture tested...
... Bioactive peptides are molecules of peptidic nature ... or activity which can be developed at ... and agro-food applications. In this way it ... superior properties for therapeutic applications. Primm offers ...
... is a fluorescence scanner with 1 or ... Packing, Protein, CGH, ) spotted on standard ... of InnoScan700 scanners include three different models:, ... a simultaneous dual fluorescence scanner (635nm and ...
... neurons in vesicles called synaptosomes. ... bouton. Synaptosomes may be centrifuged ... cellular debris. Abnormalites in neurotransmitter release ... condtions. Conditions of release may ...
Biology Products: