Navigation Links
MIT engineers design 'living materials'
Date:3/23/2014

an capture nonliving materials such as gold nanoparticles, incorporating them into the biofilms.

By programming cells to produce different types of curli fibers under certain conditions, the researchers were able to control the biofilms' properties and create gold nanowires, conducting biofilms, and films studded with quantum dots, or tiny crystals that exhibit quantum mechanical properties. They also engineered the cells so they could communicate with each other and change the composition of the biofilm over time.

First, the MIT team disabled the bacterial cells' natural ability to produce CsgA, then replaced it with an engineered genetic circuit that produces CsgA but only under certain conditions specifically, when a molecule called AHL is present. This puts control of curli fiber production in the hands of the researchers, who can adjust the amount of AHL in the cells' environment. When AHL is present, the cells secrete CsgA, which forms curli fibers that coalesce into a biofilm, coating the surface where the bacteria are growing.

The researchers then engineered E. coli cells to produce CsgA tagged with peptides composed of clusters of the amino acid histidine, but only when a molecule called aTc is present. The two types of engineered cells can be grown together in a colony, allowing researchers to control the material composition of the biofilm by varying the amounts of AHL and aTc in the environment. If both are present, the film will contain a mix of tagged and untagged fibers. If gold nanoparticles are added to the environment, the histidine tags will grab onto them, creating rows of gold nanowires, and a network that conducts electricity.

'Cells that talk to each other'

The researchers also demonstrated that the cells can coordinate with each other to control the composition of the biofilm. They designed cells that produce untagged CsgA and also AHL, which then stimulates other cells to start prod
'/>"/>

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Chemical spill activates Virginia Tech engineers in effort to determine long-term effects
2. Engineers teach old chemical new tricks to make cleaner fuels, fertilizers
3. Duke engineers make strides toward artificial cartilage
4. UCLA engineers develop new metabolic pathway to more efficiently convert sugars into biofuels
5. Stanford engineers monitor heart health using paper-thin flexible skin
6. Natures phenomena might teach Virginia Tech engineers new tricks
7. Cornell engineers solve a biological mystery and boost artificial intelligence
8. Iowa State computer, electrical engineers working to help biologists cope with big data
9. Maintaining Earths sustainability: Scientists, engineers, educators take coordinated approach
10. Nanoengineers can print 3D microstructures in mere seconds
11. WHOI scientists/engineers partner with companies to market revolutionary new instruments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... September 16, 2014 Schizophrenia is associated with increased ... body of research suggests that the relationship between schizophrenia ... patients to use nicotine to self-medicate symptoms and cognitive ... published in the current issue of Biological Psychiatry ... that the level of nicotine receptors in the brain ...
(Date:9/16/2014)... practically all vital functions in an organism. For ... particular substances and control immune system responses. Researchers ... function independently of each other, but instead form ... networks, you find many similarities with online social ... of Plant Systems Biology. "Some proteins are good ...
(Date:9/15/2014)... Human skin and gut microbes influence processes from digestion ... are the most biodiverse terrestrial ecosystems on the planet, ... trees in the tropics. Smithsonian scientists and colleagues working ... samples from a single tree were home to more ... from 57 tree species contained more than 7,000 different ...
Breaking Biology News(10 mins):Smoking and schizophrenia linked by alterations in brain nicotine signals 2Good networkers make prime targets 2Smithsonian scientists discover tropical tree microbiome in Panama 2
... model in mice because their symptoms are complex and ... transferred to a mouse. The lack of animal models ... strategically altering a protein-making molecule, a mouse was made ... and cause paralysis of the arms and legs in ...
... for making some of our immune proteins into the inflammatory ... that will appear in the June 8 issue of the ... study, conducted by a team of researchers in Italy, also ... those genes into risk factors for intestinal disorders. ...
... in <A HREF=",http://chinese.eurekalert.org/zh/pub_releases/2009-05/bc-pmp051909.php,">Chinese . A protein ... to take on a similar role in bacterial cells, ... journal BMC Microbiology . The Arabidopsis thaliana ... cells, polar regions keeping cell division at its ...
Cached Biology News:A new mouse model provides insight into genetic neurological disorders 2Immune genes adapt to parasites 2Plant Min protein sits tight and rescues E. coli 2
(Date:9/16/2014)... Pharma Packaging Solutions announced ... for their 89th year in business. Adding ... Packaging Solutions is preparing packaging operations changes ... new procedures. Establishing training and system validation ... Pharma Packaging Solutions will be ready to ...
(Date:9/16/2014)... NEW ORLEANS , Sept. 16, 2014 ... Austin, Texas -based cybersecurity company focused on ... 2FA ONE, will support the ability to generate a ... As a pioneer of user-based RFID authentication, ... used for physical access, for many years. RFID authentication ...
(Date:9/15/2014)... , Sept. 15, 2014   Global ... innovator of scientific products and services for satellite ... Acquisition Solution for Integrated Services (OASIS) from the ... GST was selected to provide the government best-value ... Small Business (SB) category in Pool 4. The ...
(Date:9/15/2014)... go downhill fast when a patient has sepsis, a ... a patient,s blood -- often too fast for antibiotics ... spleen and developed by a team at Harvard,s Wyss ... way doctors treat sepsis. , "Even with the ... care units at least 30 percent of the time," ...
Breaking Biology Technology:Adding Serialization Capabilities and Expanded Capacity, Pharma Packaging Solutions Is Preparing for 89th Year of Business 22FA, Inc. Announces RFID-based One-Time Password (OTP) Authentication 2Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 2Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 3Blood-cleansing biospleen device developed for sepsis therapy 2Blood-cleansing biospleen device developed for sepsis therapy 3Blood-cleansing biospleen device developed for sepsis therapy 4
... 16 Today, Grifols S.A. (Grifols), a global healthcare ... new national testing laboratory in San Marcos, Texas at ... Construction of the laboratory represents the first phase ... production facilities. When completed, the new facilities will ...
... interactions of millions of proteins. These are the building blocks ... problem is that proteins are extremely difficult to study, particularly ... in all sizes and weights. Now, Kris Gevaert from VIB/Ghent ... have achieved a breakthrough in protein research. Using yeast, they ...
... 21, Inc. (Nasdaq: NXXI ), the developer and ... and Diabetes Essentials® brands that help consumers manage blood ... chronic joint pain, today announced financial results for the ... 30, 2009. , For the quarter ended June ...
Cached Biology Technology:Grifols Breaks Ground on New National Testing Laboratory 2Powerhouses in the cell dismantled 2Nutrition 21 Announces Financial Results for Q4 of Fiscal 2009 and Full Year Fiscal 2009 2Nutrition 21 Announces Financial Results for Q4 of Fiscal 2009 and Full Year Fiscal 2009 3Nutrition 21 Announces Financial Results for Q4 of Fiscal 2009 and Full Year Fiscal 2009 4Nutrition 21 Announces Financial Results for Q4 of Fiscal 2009 and Full Year Fiscal 2009 5Nutrition 21 Announces Financial Results for Q4 of Fiscal 2009 and Full Year Fiscal 2009 6
... optically clear polystyrene with frosted labeling ... for cell counting. 100% integrity tested. ... new product number, created to easily ... no availability yet, please order under ...
Packaging: package with 500 l Patent/trademark/license (electronic): (r) Registered trademark of Molecular Probes...
... VersaDoc MP 4000 System is a ... system capable of supporting a wide ... chemiluminescence, densitometry, and chemiflourescence. Red, ... imaging of multiplexed fluorescent samples, reducing ...
... hydrophobic barrier pen for immunohistochemistry and in ... frozen or paraffin-embedded tissue sections mounted on ... heat-stable, water-repellent barrier that keeps staining reagents ... of reagents when differentially staining two sections ...
Biology Products: