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MIT creates tiny backpacks for cells
Date:11/6/2008

ed onto a surface. The bottom layer tethers the polymer to the surface, the middle layer contains the payload, and the top layer serves as a "hook" that catches and binds cells.

Once the layers are set up, cells enter the system and flow across the surface, getting stuck on the polymer hooks. The patch is then detached from the surface by simply lowering the temperature, and the cells float away, with backpacks attached.

"The rest of the cell is untouched and able to interact with the environment," said Albert Swiston, lead author of the paper and a graduate student in materials science and engineering.

The researchers found that T cells with backpacks were able to perform their normal functions, including migrating across a surface, just as they would without anything attached.

By loading the backpacks with magnetic nanoparticles, the researchers can control the cells' movement with a magnetic field.

Because the polymer synthesis and assembly takes place before the patches are attached to cells, there is plenty of opportunity to tweak the process to improve the polymers' effectiveness and ensure they won't be toxic to cells, the researchers say.


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Contact: Teresa Herbert
therbert@mit.edu
617-258-5403
Massachusetts Institute of Technology
Source:Eurekalert

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