Navigation Links
MIT: Why men are more prone to liver cancer
Date:1/15/2008

CAMBRIDGE, Mass.--A fundamental difference in the way males and females respond to chronic liver disease at the genetic level helps explain why men are more prone to liver cancer, according to MIT researchers.

This is the first genome-wide study that helps explain why there is such a gender effect in a cancer of a nonreproductive organ, where you wouldn't expect to see one, said Arlin Rogers, an MIT experimental pathologist and lead author of a paper that appeared last month in the journal Cancer Research.

Men develop liver cancer at twice the rate of women in the United States. In other countries, especially in Asia, the rate for men can be eight or 10 times that for women.

Liver cancer is the fifth most common cancer in the world and the third-biggest killer. Rates in the United States are lower than those in other countries but are rising rapidly, in part due to high hepatitis C infection rates during the 1970s from blood transfusions and IV drug abuse. Obesity and type 2 diabetes are additional risk factors of current concern.

It's an epidemic waiting to happen, said Rogers, a principal research scientist in MIT's Division of Comparative Medicine.

Male and female livers are inherently different, with most of the differences arising during puberty when male livers are exposed to periodic bursts of growth hormone. This prompts male livers to express different genes than female livers, which explains why men and women can have different reactions to certain antibiotics and other medications.

The MIT team studied mice, which also have higher liver cancer rates among males. The mice were infected with Helicobacter hepaticus, which produces the same hepatitis symptoms characteristic of human hepatitis B and C.

In humans and mice, healthy males and females both can respond to acute toxins and other stresses. But the male liver is less well equipped to cope with the chronic inflammation induced by cer
'/>"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2

Related biology news :

1. The importance of mangrove conservation in tsunami prone regions
2. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
3. Clearance of hepatitis C viral infection after liver transplantation
4. Targeting nerve growth factor may cure liver cancer
5. Mountain pine beetle: Canadas new government delivers
6. Using green chemistry to deliver cutting-edge drugs
7. Mixing large doses of both acetaminophen painkiller and caffeine may increase risk of liver damage
8. Jumping genes could make for safer gene delivery system
9. Nanoengineers mine tiny diamonds for drug delivery
10. Computer solution to delivery problem
11. Genetic ancestral testing cannot deliver on its promise, study warns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... Washington, USA -- "Nature has developed, very cleverly, some ... desire in optical design," said Joseph Shaw, director of ... we explore surfaces and structures at the nanoscale, we,ll ... in San Diego in August during a conference called ... Shaw and Rongguang Liang of the University of Arizona ...
(Date:9/17/2014)... Spanish researchers have obtained the first partial genome sequence ... pig found at the site of the Montsoriu Castle ... pig is closely related to today,s Iberian pig. Researchers ... with modern Iberian pigs. , The study, published in ... of pig species, and particularly on that of the ...
(Date:9/17/2014)... team of researchers working on a Carnegie expedition in ... rates have plummeted 40% since the mid-1970s. The scientists ... role in this perilous slowdown. , In a ... reefs, the team compared current measurements of the growth ... with similar measurements taken more than 30 years ago. ...
Breaking Biology News(10 mins):Nature's designs inspire research into new light-based technologies 2Nature's designs inspire research into new light-based technologies 3Iberian pig genome remains unchanged after 5 centuries 2Coral growth rate plummets in 30-year comparison 2
... Veterinary Medicine have identified a gene in Labrador retriever dogs ... intense hunting or retrieving exercise, activities these dogs are trained ... hind limbs. In most cases, their legs get wobbly ... dogs may die. Labradors are the most common dog ...
... mean solar or wind power. In fact, the alternative ... engineering professor James Dumesic look a lot like the ... That,s because the new fuels are identical at the ... is where they come from. Funded by the ...
... have succeeded in tracing intricate biochemical networks involving a ... in specific tissues at particular moments in development. ... Krainer, Ph.D., both professors at CSHL and heads of ... call RNA splicing. Splicing is a key step ...
Cached Biology News:U of M researchers identify gene linked to common ailment in labrador retrievers 2New process derives 'green gasoline' from plant sugars 2CSHL team traces extensive networks regulating alternative RNA splicing 2CSHL team traces extensive networks regulating alternative RNA splicing 3CSHL team traces extensive networks regulating alternative RNA splicing 4
(Date:9/17/2014)... 17, 2014 Shimadzu Scientific ... Chromatograph (2D-LC), which offers a powerful separation ... The system provides a new level of ... is beneficial to scientists analyzing pharmaceutical impurities, ... products. , Comprehensive 2D-LC combines two independent ...
(Date:9/17/2014)... , Sept. 17, 2014 BioClinica®, Inc., ... eClinical Solutions, today announced three of its experts are ... for Clinical Data Management to be held September 28 ... . The Company also announced the innovative ... overall quality in clinical trials acquired earlier this year, ...
(Date:9/17/2014)... Hussey Copper , a leader in ... copper, announces Gilmour Academy Ice Arena,s conversion of more ... solid touch surface to help protect against bacteria.  MD-Cu ... that kills greater than 99.9% of MRSA, E-coli and ... , Innovative Gilmour Academy ...
(Date:9/17/2014)... RXi Pharmaceuticals Corporation (NASDAQ: ... developing and commercializing innovative therapies addressing major unmet ... has been granted a patent by the United ... delivery system for delivering its "original" RNAi compounds ... treatment of diseases with an inflammatory component. Potential ...
Breaking Biology Technology:Shimadzu’s New Nexera-e Two Dimensional Comprehensive Liquid Chromatograph Empowers Laboratories to Separate Even the Most Complex Mixtures 2BioClinica to Present at 20th Annual SCDM Conference 2BioClinica to Present at 20th Annual SCDM Conference 3Innovative Gilmour Academy Ice Arena changes more than 200 fixtures to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 2Innovative Gilmour Academy Ice Arena changes more than 200 fixtures to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 3RXi Pharmaceuticals Strengthens Intellectual Property Portfolio 2RXi Pharmaceuticals Strengthens Intellectual Property Portfolio 3RXi Pharmaceuticals Strengthens Intellectual Property Portfolio 4
... , AquaPure Genomic DNA Isolation ... range: 210 g DNA, , Method ... 1. Dissect tissue sample quickly and freeze in liquid nitrogen. Store , ... , keep tissue on ice at all times including when tissue ...
... Lisa Starr and William D. Huse , Ixsys, ... San Diego, California 92121 , , ... M13 vectors have been used extensively for subcloning mainly because the , ... DNA is a superior starting material for sequencing and in vitro ...
... and Ian Spendlove, Cancer Research,Campaign Academic Unit, Nottingham City Hospital, Hucknall Road,Nottingham NG5 1PB, ... Introduction , ... method of DNA vaccine delivery, and has been ... protective immunity in animal models to both infectious diseases and cancer , ...
Cached Biology Technology:Genomic DNA Isolation From 510 mg Marine Invertebrate Tissue 2Electrotransformation of E. coli With M13 DNA 2Electrotransformation of E. coli With M13 DNA 3Electrotransformation of E. coli With M13 DNA 4Electrotransformation of E. coli With M13 DNA 5Electrotransformation of E. coli With M13 DNA 6Delivery of pCMV-S DNA Using the Helios Gene Gun System Is Superior to Intramuscular Injection in Balb/c Mice 2Delivery of pCMV-S DNA Using the Helios Gene Gun System Is Superior to Intramuscular Injection in Balb/c Mice 3Delivery of pCMV-S DNA Using the Helios Gene Gun System Is Superior to Intramuscular Injection in Balb/c Mice 4Delivery of pCMV-S DNA Using the Helios Gene Gun System Is Superior to Intramuscular Injection in Balb/c Mice 5Delivery of pCMV-S DNA Using the Helios Gene Gun System Is Superior to Intramuscular Injection in Balb/c Mice 6Delivery of pCMV-S DNA Using the Helios Gene Gun System Is Superior to Intramuscular Injection in Balb/c Mice 7Delivery of pCMV-S DNA Using the Helios Gene Gun System Is Superior to Intramuscular Injection in Balb/c Mice 8
XEDAR Antibody...
Rabbit Anti-JNK1/SAPK pan, Polyclonal Antibody...
Low melting point. Ideally suited for in gel enzymatic reactions. Gelling temp. 24-28C Melting temp. 65C. EEO 0.12 Resolution 0.5-20 kb; Rnase/Dnase: none detected....
Rabbit polyclonal to XTP4 ( Abpromise for all tested applications). entrezGeneID: 84299 SwissProtID: Q9BRT3...
Biology Products: