Navigation Links
MIT: Remote-control nanoparticles deliver drugs directly into tumors
Date:11/16/2007

CAMBRIDGE, MA--MIT scientists have devised remotely controlled nanoparticles that, when pulsed with an electromagnetic field, release drugs to attack tumors. The innovation, reported in the Nov. 15 online issue of Advanced Materials, could lead to the improved diagnosis and targeted treatment of cancer.

In earlier work the team, led by Sangeeta Bhatia, M.D.,Ph.D., an associate professor in the Harvard-MIT Division of Health Sciences & Technology (HST) and in MIT's Department of Electrical Engineering and Computer Science, developed injectable multi-functional nanoparticles designed to flow through the bloodstream, home to tumors and clump together. Clumped particles help clinicians visualize tumors through magnetic resonance imaging (MRI).

With the ability to see the clumped particles, Bhatias co-author in the current work, Geoff von Maltzahn, asked the next question: Can we talk back to them?

The answer is yes, the team found. The system that makes it possible consists of tiny particles (billionths of a meter in size) that are superparamagnetic, a property that causes them to give off heat when they are exposed to a magnetic field. Tethered to these particles are active molecules, such as therapeutic drugs.

Exposing the particles to a low-frequency electromagnetic field causes the particles to radiate heat that, in turn, melts the tethers and releases the drugs. The waves in this magnetic field have frequencies between 350 and 400 kilohertzthe same range as radio waves. These waves pass harmlessly through the body and heat only the nanoparticles. For comparison, microwaves, which will cook tissue, have frequencies measured in gigahertz, or about a million times more powerful.

The tethers in the system consist of strands of DNA, a classical heat sensitive material, said von Maltzahn, a graduate student in HST. Two strands of DNA link together through hydrogen bonds that break when heated. In the presence of the ma
'/>"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
2. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
3. Mountain pine beetle: Canadas new government delivers
4. Using green chemistry to deliver cutting-edge drugs
5. Jumping genes could make for safer gene delivery system
6. Nanoengineers mine tiny diamonds for drug delivery
7. Computer solution to delivery problem
8. Genetic ancestral testing cannot deliver on its promise, study warns
9. Carnegie Mellon researchers to develop new drug delivery system
10. Socioeconomic position associated with effectiveness of HIV drugs
11. MIT model could improve some drugs effectiveness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... that prompts millions of Americans to undertake jaunts into the ... a little longer within a century, according to new research. ... areas of the United States as summer temperatures linger later ... Global Ecology and Biogeography . For instance, the paper ... tree of New Hampshire could change color one to ...
(Date:9/18/2014)... genetic information is stored in DNA, tiny strands of ... our bodies. To express this genetic data, our DNA ... instructions into proteins that perform tasks in our cells. ... type of RNA molecule. Unlike all other known RNAs, ... Although circRNA molecules are abundant, little has been known ...
(Date:9/18/2014)... AZ, Sept. 18, 2014 -- Arizona turned its newborn ... just a few short months, earning it the first-ever Newborn ... The March of Dimes presented Will Humble, M.P.H., Arizona,s Department ... held here today. Mr. Humble established a policy of full ... to send newborn blood samples to the lab for analysis, ...
Breaking Biology News(10 mins):Fall foliage season may be later, but longer on warmer Earth 2Fall foliage season may be later, but longer on warmer Earth 3Fall foliage season may be later, but longer on warmer Earth 4Scientists find how mysterious 'circular RNA' is formed, claim muscular dystrophy link 2March of Dimes honors Arizona with first-ever newborn screening award 2March of Dimes honors Arizona with first-ever newborn screening award 3
... rise, so does the pressure on the plant kingdom. The ... will absorb some of the extra CO 2 and ... now, researchers have hypothesized about one major roadblock: nitrogen. ... they take up from the atmosphere. The more they get, ...
... Wash.There really is a balance of nature, but as accepted ... Washington State University researchers writing in the journal Nature ... typical of organic farms work better at fighting pests and ... pests and their natural enemies in potatoes and found organic ...
... Alberta, June 30, 2010 Innovotech Inc. (TSX-V: IOT), ... has secured funding in excess of $900,000 from Agriculture ... its unique, environmentally friendly seed treatment and plant spray ... infections. "With the potential to increase crop yields ...
Cached Biology News:Nitrogen pollution alters global change scenarios from the ground up 2Nitrogen pollution alters global change scenarios from the ground up 3'Balanced' ecosystems seen in organic ag better at controlling pests 2
(Date:9/18/2014)... September 18, 2014 ... http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has announced the addition ... Global Strategic Business Report" report ... ,This report analyzes the worldwide markets ... by the following Product Segments: Polymeric ...
(Date:9/18/2014)... Washington, D.C. (PRWEB) September 18, 2014 ... Dick Durbin and Sen. Jim Risch for National Lab ... research projects from across the national laboratory system. Durbin ... Caucus, which aims to increase awareness of the reach ... breakthrough technologies and discoveries to address some of our ...
(Date:9/18/2014)... 2014 Research and Markets ... N-acetylcysteine Industry Report 2014" report to their ... Report 2014 is a professional and in-depth study ... industry. The report provides a basic ... and industry chain structure. The N-acetylcysteine market analysis ...
(Date:9/18/2014)... , Sept. 18, 2014 Research ... "Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, ... report to their offering. The global ... CAGR of 22.7% from 2014 to 2019. Factors such ... growing adoption of companion diagnostics by the pharmaceutical industry, ...
Breaking Biology Technology:Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3Global N-acetylcysteine Industry Report 2014 2Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 2Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 3
... Arpida Ltd,(SIX: ARPN) announced today its financial results for the six ... to date, - Regulatory setback for intravenous iclaprim in ... - Company restructuring completed, , Cash ... CFO Harry Welten, MBA, commented: "Our cost-saving measures ...
... , , , , ... the healthcar e field using technology in ... patient care, what isn,t clear is the exact role technology will play ... the right information, be it clinical or administrative, at the right time, ...
... particles have been used to bring stem cells to ... to increase the capacity of cells to repair damaged ... disciplinary research, published in The Journal of the ... technique where endothelial progenitor cells a type of ...
Cached Biology Technology:Arpida Reports Interim Results For Six Months to 30 June 2009 2Healthcare Continues to Use OnBase in 'Meaningful' Ways 2Healthcare Continues to Use OnBase in 'Meaningful' Ways 3Healthcare Continues to Use OnBase in 'Meaningful' Ways 4Nanomagnets guide stem cells to damaged tissue 2
...
... Perkin Elmer UltraVIEW system and want to enjoy ... iQ software? No problem. Our experienced team ... existing microscope, lasers, Sutter filter wheel, Piezo Stage ... with our precision controller unit and workstation... for ...
... The DNA Engine Dyad instrument is ... Featuring MJ's world-class thermal performance, ... color display, as well as point-and-click navigation ... The Dyad can be easily and economically ...
...
Biology Products: