Navigation Links
MIT: Prenatal arsenic exposure detected in newborns
Date:11/22/2007

CAMBRIDGE, Mass MIT researchers have found that the children of mothers whose water supplies were contaminated with arsenic during their pregnancies harbored gene expression changes that may lead to cancer and other diseases later in life. In addition to establishing the potential harmful effects of these prenatal exposures, the new study also provides a possible method for screening populations to detect signs of arsenic contamination.

This is the first time evidence of such genome-wide changes resulting from prenatal exposure has ever been documented from any environmental contaminant. It suggests that even when water supplies are cleaned up and the children never experience any direct exposure to the pollutant, they may suffer lasting damage.

The research will be reported in the Nov. 23 issue of PLoS Genetics (published by the Public Library of Science).

The evidence comes from studies of 32 mothers and their children in a province of Thailand that experienced heavy arsenic contamination from tin mining. Similar levels of arsenic are also found in many other regions, including the US Southwest.

The research was led by Mathuros Ruchirawat, Director of the Laboratory of Environmental Toxicology of the Chulabhorn Research Institute (CRI) in Thailand, and Leona D. Samson, Director of MITs Center for Environmental Health Sciences (CEHS) and the American Cancer Society Professor in the Departments of Biological Engineering and Biology at MIT. The first author of the study is Rebecca C. Fry, a research scientist at CEHS. Coauthors include Panida Navasumrit of the CRI and Chandni Valiathan, graduate student at MITs Computational and Systems Biology Initiative.

The team analyzed blood that had been collected from umbilical cords at birth. The exposure of mothers to arsenic during their pregnancy was independently determined by analyzing toenail clippings the most reliable way of detecting past arsenic exposure.

The team found a collection of about 450 genes whose expression had been turned on or turned off in babies who had been exposed to arsenic while in the womb. That is, these genes had either become significantly more active (in most cases) or less active than in unexposed babies.

We were looking to see whether we could have figured out that these babies were exposed in utero just by using the gene expression screening on the stored blood samples, Samson says. The answer was a resounding yes.

Further, the team found that a subset of just 11 of these genes could be used as a highly reliable test for determining whether babies had been born to mothers exposed to arsenic during pregnancy. Since blood samples are already taken routinely for medical tests this may provide an easier way of screening for such exposure.

The gene expression changes the group found in the exposed children are mostly associated with inflammation, which can lead to increased cancer risk. Recognizing the damaging effects of the arsenic exposure, the government has provided alternative water sources to the affected villages, Fry says, which means that following these children as they grow older (they are now toddlers) has the potential to show how long-lasting the effects of the prenatal exposure may be. However, she adds, this may be complicated by the fact that many people are still using the local water for cooking.

It's not yet clear how long the changes may last. We will be testing whether these gene expression changes have persisted in these children, Fry says.

This is the first time such a response to prenatal arsenic exposure has been found in humans. But it is not entirely unexpected, Samson explains, because in mice, when mothers are transiently exposed to arsenic in the drinking water, their progeny, in their adult life, are much more cancer-prone.

Further research could include studies of possible ways of reversing or mitigating the damage, perhaps through dietary changes, nutritional supplements, or drug treatments to counteract the gene expression changes.

Also, the group plans to do follow-up studies in different locations and with larger groups of subjects to confirm the value of the 11 marker genes as a reliable indicator of arsenic exposure. The researchers also aim to determine whether the gene expression changes are specific to arsenic.

This study is an example of the CEHSs efforts to promote collaborative interdisciplinary research into global environmental health issues, specifically in the developing world.


'/>"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
Source:Eurekalert

Related biology news :

1. Folic acid lowers blood arsenic levels, according to Mailman School of Public Health study
2. Folic acid lowers blood arsenic levels in Bangladesh
3. Dartmouth researchers show effects of low dose arsenic on development
4. Meth exposure in young adults leads to long-term behavioral consequences
5. UCR engineers to develop new tool to measure how environmental exposures affect health
6. Researchers developing device to predict proper light exposure for human health
7. Nanoparticle exposures happen, says expert
8. Time spent in car drives up air pollution exposure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/21/2016)... --> ... report "Emotion Detection and Recognition Market by Technology (Bio-Sensors, NLP, ... Voice Recognition and Others), Services, Application Areas, End ... published by MarketsandMarkets, the global Emotion Detection and ... Billion by 2020, at a CAGR of 31.9%, ...
(Date:1/20/2016)... 2016  Synaptics Incorporated (NASDAQ: SYNA ), ... announced sampling of S1423, its newest ClearPad ® ... screen applications including smartwatches, fitness trackers, and touch ... rectangular shapes, as well as thick and curved ... on screen, while wearing gloves, and supports swipes ...
(Date:1/13/2016)... January 13, 2016 --> ... a new market report titled - Biometric Sensors Market - ... 2015 - 2023. According to the report, the global biometric sensors ... anticipated to reach US$1,625.8 mn by 2023, expanding at ... terms of volume, the biometric sensors market is expected ...
Breaking Biology News(10 mins):
(Date:2/9/2016)... , Feb. 9, 2016 This market research ... current and future prospects of the market in terms ... include companies engaged in the manufacture of microbiology culture ... summary with a market snapshot providing the overall information ... this report. This section also provides the overall information ...
(Date:2/8/2016)... ON , Feb. 8, 2016 /PRNewswire/ - BIOREM Inc. ... to the top ten finalists for clean technology companies in ... are the top 10 companies listed on the TSX Venture ... oil & gas, clean technology & life sciences, ... with equal weighting given to return on investment, market cap ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... ... Board of Directors. Todorow is the Executive Vice President for Corporate Services and ... Todorow oversees Finance, Accounts Payable, Payroll, Billing Operations, Treasury, Managed Care Contracting, Supply ...
(Date:2/8/2016)... , Feb. 8, 2016  NanoViricides, Inc. (NYSE MKT: NNVC) ... CEO, Eugene Seymour , MD, MPH, will present information about ... the Waldorf-Astoria Hotel in New York City . ... be in the Windsor Room at 5:30PM EST. Registered attendees can ... New York City . --> ...
Breaking Biology Technology: