Navigation Links
MIT: New tissue scaffold regrows cartilage and bone
Date:5/11/2009

CAMBRIDGE, Mass.--MIT engineers and colleagues have built a new tissue scaffold that can stimulate bone and cartilage growth when transplanted into the knees and other joints.

The scaffold could offer a potential new treatment for sports injuries and other cartilage damage, such as arthritis, says Lorna Gibson, the Matoula S. Salapatas Professor of Materials Science and Engineering and co-leader of the research team with Professor William Bonfield of Cambridge University.

"If someone had a damaged region in the cartilage, you could remove the cartilage and the bone below it and put our scaffold in the hole," said Gibson. The researchers describe their scaffold in a recent series of articles in the Journal of Biomedical Materials Research.

The technology has been licensed to Orthomimetics, a British company launched by one of Gibson's collaborators, Andrew Lynn of Cambridge University. The company recently started clinical trials in Europe.

The scaffold has two layers, one that mimics bone and one that mimics cartilage. When implanted into a joint, the scaffold can stimulate mesenchymal stem cells in the bone marrow to produce new bone and cartilage. The technology is currently limited to small defects, using scaffolds roughly 8 mm in diameter.

The researchers demonstrated the scaffold's effectiveness in a 16-week study involving goats. In that study, the scaffold successfully stimulated bone and cartilage growth after being implanted in the goats' knees.

The project, a collaboration enabled by the Cambridge-MIT Institute, began when the team decided to build a scaffold for bone growth. They started with an existing method to produce a skin scaffold, made of collagen (from bovine tendon) and glycosaminoglycan, a long polysaccharide chain. To mimic the structure of bone, they developed a technique to mineralize the collagen scaffold by adding sources of calcium and phosphate.

Once that was done
'/>"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2

Related biology news :

1. NIST issues first reference material for tissue engineering
2. Lithium may help radiation target cancer, spare healthy tissue
3. Gene therapy appears safe to regenerate gum tissue
4. Model tissue system reveals cellular communication via amino acids
5. Therapeutic hypothermia is promising strategy to minimize tissue damage
6. Stem cells replace stroke-damaged tissue in rats
7. A new way to assemble cells into 3-D microtissues
8. High-fat diets inflame fat tissue around blood vessels, contribute to heart disease
9. Advancement in tissue engineering promotes oral wound healing
10. Building better bones and tissue in the lab
11. Columbia University scientist devises new way to more rapidly generate bone tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/14/2014)... cancer tumors scavenge and hoard copper that is an ... be a fatal weakness. , Researchers at Duke ... cells by delivering a trove of copper along with ... with the mineral, leaving non-cancer cells healthy. , The ... for other uses, could soon be tested in clinical ...
(Date:10/14/2014)... been millions of years since T. rex ... Ohio University scientists is breathing life back into dinosaurs ... snouts. The research has important implications for how dinosaurs ... enhance the sense of smell and cool their brains. ... University doctoral student Jason Bourke, lead author of the ...
(Date:10/14/2014)... how to produce enough food to feed the world ... Organization of the United Nations predicts that food production ... feed a growing global population, and plants are one ... Plants—grains, cereals, fruits, vegetables, and more—feed humans directly ... tap into our knowledge of how plants work to ...
Breaking Biology News(10 mins):Prostate cancer's penchant for copper may be a fatal flaw 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3Building a bridge from basic botany to applied agriculture 2Building a bridge from basic botany to applied agriculture 3
... 7, 2012 Compared with open farmland, wooded "shade" plantations ... a new University of Utah study says forests remain the ... as open farmland replaces forests and "agroforests" where crops ... and shifts in the populations of various types of birds ...
... New York University College of Nursing,s (NYUCN) Joyce K. ... Professor and Founding Director of the Division of Special ... a $2.5 million four-year National Institutes of Health (NIH) ... bowel syndrome (IBS) constipation". The primary ...
... with a black mask, pale belly and scarlet breast ... named by Cornell University graduates following an expedition to the ... , is described in a paper published in the July ... of the American Ornithologists, Union. The new species was ...
Cached Biology News:Birds do better in 'agroforests' than on farms 2Birds do better in 'agroforests' than on farms 3Birds do better in 'agroforests' than on farms 4Birds do better in 'agroforests' than on farms 5NYU College of Nursing's Dr. Anastasi awarded $2.5 million from NIH to study IBS symptom management 2New bird species discovered in 'cloud forest' of Peru 2
(Date:10/17/2014)... looking-glass to Wonderland, mirrors in the real world can ... new class of mirror that works like no other. ... (OSA) new high-impact journal Optica , ... type of mirror that forgoes a familiar shiny metallic ... unusual magnetic property of a non-metallic metamaterial. , ...
(Date:10/17/2014)... 17, 2014 Bioquell, provider of ... by health facilities around the world to decontaminate ... treated. Among the many places the hydrogen peroxide ... Presbyterian Hospital Dallas and at the National Institutes ... robots have been utilized to decontaminate patient rooms, ...
(Date:10/17/2014)... The Europe Fuel Additives Market report defines ... analysis and forecast of revenue. , Browse through the ... get an idea of the in-depth analysis provided. This ... European fuel additives market, and is supported by various ... Fuel additives are chemicals that are used to enhance ...
(Date:10/17/2014)... The Middle East and Africa Location Based ... in the Middle East and Africa with analysis and forecast ... million in 2014 to $3,403.1 million by 2019, at a ... the TOC of the Middle East and Africa Location Based ... in-depth analysis provided. It also provides a glimpse of the ...
Breaking Biology Technology:Magnetic mirrors enable new technologies by reflecting light in uncanny ways 2Magnetic mirrors enable new technologies by reflecting light in uncanny ways 3Magnetic mirrors enable new technologies by reflecting light in uncanny ways 4Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 2Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 3Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 4Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 5Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 6The Europe Fuel Additives Market is estimated to grow to $1,401.4 million by 2018 - New Report by MicroMarket Monitor 2The Europe Fuel Additives Market is estimated to grow to $1,401.4 million by 2018 - New Report by MicroMarket Monitor 3The Europe Fuel Additives Market is estimated to grow to $1,401.4 million by 2018 - New Report by MicroMarket Monitor 4The Middle East and Africa Location Based Services (LBS) market is estimated to reach $3,403.1 million by 2019 - New Report by MicroMarket Monitor 2The Middle East and Africa Location Based Services (LBS) market is estimated to reach $3,403.1 million by 2019 - New Report by MicroMarket Monitor 3The Middle East and Africa Location Based Services (LBS) market is estimated to reach $3,403.1 million by 2019 - New Report by MicroMarket Monitor 4
... West Allis, Wis .- Merge Healthcare has been informed ... NASDAQ for the time being, but the company does not ... Listing Qualifications Panel made the determination to continue the listing of ... 7 deadline for the filing of its annual report for the ...
... - With the support of a local equity investor, ... game development, and it is intent on marketing its games ... , and Nintnedo . , ,Selling its products to ... Frozen Codebase Productions, LLC and its president, Ben ...
... - After receiving FDA clearance for two new brain ... prepared to market its products to healthcare providers. , ... Center for Devices and Radiologic Health in June ... new products to its line of brain mapping solutions ...
Cached Biology Technology:Emerging game developer begins work on prototypes 2Kyron wins FDA approval for brain imaging technology 2
... Best: DASGIPs Process Control integrates Process ... comprehensive documentation for cultivation processes. A ... pH, dissolved oxygen, temperature and agitation ... Profiles, e.g. constant or scheduled media ...
... Microarrays designed for immunological studies, vaccine ... the flexible and powerful Paraflo microfluidic ... available as part of our comprehensive ... Custom Probe Content Probe content ...
... designed to meet your needs. Two probe ... per array (2 arrays/1" x 3" glass ... array/slide). Features ... extended length delivers higher sensitivity compared to ...
... Kit contains in vitro synthesized, polyadenylated transcripts ... probes on Agilents microarrays, with minimal self- ... positive microarray control in the hybridization protocol. ... a required component of the Agilent One-Color ...
Biology Products: