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MIT: Making waves in the brain
Date:4/26/2009

activity with precise timing via a laser and an optical fiber over the brain," explains co-lead author Marie Carln, a postdoctoral fellow at the Picower Institute.

The trick for inducing gamma waves was the selective activation of the "fast-spiking" interneurons, named for their characteristic pattern of electrical activity. When these cells were driven with high frequency laser pulses, the illuminated region of cortex started to produce gamma oscillations. "We've shown for the first time that it is possible to induce a specific brain state by activating a specific cell type" says co-author Christopher Moore, associate professor of neuroscience and an investigator in the McGovern Institute. In contrast, no gamma oscillations were induced when the fast-spiking interneurons were activated at low frequencies, or when a different class of neurons was activated.

The authors further showed that these brain rhythms regulate the processing of sensory signals. They found that the brain's response to a tactile stimulus was greater or smaller depending on exactly where the stimulus occurred within the oscillation cycle. "It supports the idea that these synchronous oscillations are important for controlling how we perceive stimuli," says Moore. "Gamma rhythms might serve to make a sound louder, or a visual input brighter, all based on how these patterns regulate brain circuits."

Because this new approach required a merger of expertise from neuroscience and molecular genetics, three different laboratories contributed to its completion. In addition to Tsai, Moore and Carln of MIT, co-authors include Jessica Cardin, research affiliate at the McGovern Institute and the University of Pennsylvania, and Karl Deisseroth and Feng Zhang at Stanford University. Other co-authors were Konstantinos Meletis, a postdoctoral fellow at the Picower Institute, and Ulf Knoblich, a graduate student in MIT's Department of Brain and Cognitive Sciences.


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Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2

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