Navigation Links
MGH researcher Gary Ruvkun named a co-recipient of the Lasker Award
Date:9/13/2008

discovery that plant genes could be silenced by the action of tiny RNAs similar to the worm sequences studied by Ruvkun and Ambros implied that the same mechanism operated in plants and animals.

In 2000 Ruvkun's team discovered let-7, another tiny regulatory RNA that shuts down its target gene the same way that lin-4 silences lin-14. They also found that the let-7 RNA sequence had been snipped out of a larger RNA molecule that folds back on itself in a hairpin shape. Later that year Ruvkun published evidence that animals from fish to flies to humans have their own versions of let-7, implying that the mechanism is universal to all but the most primitive animal species.

In 2001 Ruvkun collaborated with Craig Mello, PhD, of UMass and Andrew Fire, PhD, then at the Carnegie Institution, to show that the microRNAs of both lin-4 and let-7 are released from their precursor hairpin RNA molecules by the enzyme Dicer, which is also critical to the RNA interference process that Mello and Fire had discovered and for which they received the 2006 Nobel Prize.

It now appears that the human genome contains between 500 and 1,000 microRNAs involved in a broad range of normal and disease-related activities. Researchers have just begun exploring their potential for the diagnosis, prognosis and treatment of disorders. In addition to continuing investigation of RNA's role in controlling gene expression, Ruvkun's team studies other mechanisms involved in the development, metabolism and longevity of C. elegans, including genes involved in the regulation and storage of fat.

Ruvkun is a professor of Genetics at Harvard Medical School and an investigator at the MGH Center for Computational and Integrative Biology. He holds a bachelor's degree in Biophysics from the University of California at Berkeley and a PhD in Biophysics from Harvard University. Among the many other awards he has received some shared with Ambros and Baulcombe are the Fra
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Curbing coal emissions alone might avert climate danger, say researchers
2. Researchers develop nano-sized cargo ships to target and destroy tumors
3. Gap junction protein vital to successful pregnancy, researchers find
4. Cortisol and fatty liver: Researchers find cause of severe metabolic disorders
5. Researchers seeking to identify Alzheimers risk focus on specific blood biomarker
6. Childrens National researcher receives ACCP Distinguished Investigator Award
7. New once-a-week treatment for type 2 diabetes developed by Mount Sinai researcher
8. ISU researchers help map first plant-parasitic nematode genome sequence
9. Collaboration between researchers yields more comprehensive portrait of brain cancer
10. Tel Aviv University researchers create new stem cell screening tool
11. NYU Cancer Institute researcher among first NIH EUREKA award recipients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... April 14, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces ... the 2015 New York Design Awards under the category  ... York City Design Awards are part of a global ... 2,500 ratings from the marketplace, industry and judging panel. ...
(Date:4/9/2015)... , April 9, 2015 Synaptics Inc. (NASDAQ: ... announced today that it will report financial results for ... 23, 2015, after the close of market. The company ... investors at 2:00 p.m. PT (5:00 p.m. ET), during ... To participate on the live call, analysts and investors ...
(Date:4/2/2015)... At its 2015 ACMG Annual Clinical Genetics ... the American College of Medical Genetics and Genomics (ACMG) ... Board.  Members of the ACMG Board of Directors serve ... advancing its policies and programs. ACMG is the national ... an eventful time in medical genetics and genomics.  We ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3Synaptics to Report Third Quarter Results on April 23 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8
... ... Incident and Crash Reporting, WALL, N.J., July 1 ... finger-based biometric,identification and wireless public safety today announced an award ... related services. With this award, officers on patrol will be,able ...
... published in the July/August 2008 issue of BioScience ... , Camille Bonneaud, Joan Burnside, and Scott V. Edwards. , ... to birds, thus expanding what has been learned from studies ... ecology and evolution of the whole class. ***************, ...
... new, patented catalyst developed by scientists at the U.S. ... reliably and economically reduce between 95 and 100 percent ... has been licensed to Integrated Fuel Technologies, Inc. (IFT), ... and Kirkland. IFT plans to integrate the technology ...
Cached Biology News:Ohio Law Enforcement Agency Deploys BIO-key(R) Mobile Reporting Software 2Ohio Law Enforcement Agency Deploys BIO-key(R) Mobile Reporting Software 3BioScience tip sheet July/August 2008 2BioScience tip sheet July/August 2008 3Integrated Fuel Technologies gets worldwide license for Argonne-developed Diesel DeNOx Catalyst 2Integrated Fuel Technologies gets worldwide license for Argonne-developed Diesel DeNOx Catalyst 3
(Date:5/6/2015)... Columbia, PA (PRWEB) May 06, 2015 ... the most comprehensive lines of standard and custom ... Known for its innovative engineering and design, robust construction, ... chambers is designed to meet all of your temperature, ... to announce the addition of the TPS Smart 1.0 ...
(Date:5/6/2015)... 6, 2015 Whitefox ( ... today that it has signed an agreement with  ... PEIX ) for the delivery of an industrial scale membrane ... consumption of water, energy and emissions in ... This project is fully aligned with ...
(Date:5/5/2015)...  Blueprint Medicines (NASDAQ: BPMC ) today ... of 9,367,708 shares of common stock at a ... shares of common stock issued upon the full ... purchase additional shares. The gross proceeds from the ... $168.6 million, before underwriting discounts and estimated offering expenses. ...
(Date:5/5/2015)... Hayden-McNeil is pleased to announce they ... for smaller courses. This program is specifically designed for ... , “I’m very excited about offering our publishing ... said Jeff McCarthy, Hayden-McNeil president. “By working with more ... to make education both more effective and affordable.” , ...
Breaking Biology Technology:The TPS 3.5” Smart 1.0 Controller Raises the Tech Standard on Environmental Test Chambers 2Whitefox Signs Agreement With Pacific Ethanol Inc. 2Blueprint Medicines Announces Closing of Initial Public Offering 2Hayden-McNeil Expands Publishing Program to Service Lower Enrollment Courses 2
... Wis. - Hospitals are complex organizations and new IT ... These organization generate large volumes of data and support ... on business requirements. Automating Peripherals Inc. (API) ... Fargo, N.D., has signed a contract to purchase API's ...
... to Buinevicius, the first wave of streaming media was ... but by and large, the money hasn't followed. The ... to being a communication tool that can improve productivity ... email, corporations, government organizations and educational institutions are beginning ...
... discussed with small companies and startups, far too often ... be the cornerstone of any companys long-term survival program. ... etc., training takes priority in these companies. , ... sets can become obsolete just as fast! As new ...
Cached Biology Technology:API Signs Tech Deal for Healthcare HR Management 2The Big Differentiator, Training! 2
... General description: Designed for use with ... CLS number is a new product number, ... If showing no availability yet, please order ... contact customer service for assistance. Comp Dim: ...
... pTriEx™ vectors combine the proven features of ... systems and provides all of the benefits ... one vector backbone. The pTriEx vectors have ... target genes in all three expression systems. ...
... is a complete, flexible system designed ... samples, as is frequently required in ... around Instechs miniature Clark-style polarographic electrode. ... in diameter (3.2 mm), it is ...
... The GSTTag Monoclonal Antibody is a ... affinity to the 26 kDa glutathione-S-transferase ... This purified antibody is suitable for ... sequence expressed in E. coli , ...
Biology Products: