Navigation Links
MDC scientists show how hematopoietic stem cell development is regulated
Date:10/6/2009

self-renewal. Moreover, the HSCs were restricted in their formation of B cells and T cells (blood cells of the lymphatic system and important cells of the immune system).

However, the HSCs were able to form red blood cells, which are important for oxygen transport and belong to the blood cells of the myeloerythroid system. In other words, the DNA methylation level regulates which blood cell lineages develop or not from a hematopoietic stem cell.

Cancer stem cells

Methylation processes also play a role in numerous cancer diseases. As the MDC researchers were able to show, the DNA methylation by the enzyme Dnmt1 also controls the development of leukemic stem cells.

If the DNA methylation level is low, cancer stem cell renewal is restricted. Moreover, the formation of leukemic cells of B-cell lineage (acute B-cell leukemia ALL) is blocked.

The question is whether diseased stem cells can be switched off, possibly through a blockade of the enzyme Dnmt1. Dr. Rosenbauer and his research team want to make a more detailed investigation of this question in a further project.


'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. UK scientists working to help cut ID theft
2. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
3. Comet probes reveal evidence of origin of life, scientists claim
4. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
5. Male elephants get photo IDs from scientists
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
8. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
9. Clemson scientists shed light on molecules in living cells
10. Scientists tackle mystery mountain illness
11. T. rex quicker than Becks, say scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/18/2015)... , June 18, 2015 NXT-ID, Inc. (NASDAQ: ... focused on the growing mobile commerce market announces that its ... segment on "Money on the Mark", scheduled to air on ... June 20 th . The broadcast ... from 7:00 to 8:00pm EST. NXT-ID, Inc.,s CEO Gino ...
(Date:6/17/2015)... Germany , June 17, 2015 ... today launched new Investigator ® STR assay kits for ... the United States . The new genetic fingerprint kits ... markers (short tandem repeats or STRs) for DNA matching. They ... quality of DNA in each sample, a novel QIAGEN technology ...
(Date:6/17/2015)... BEACH GARDENS, Fla. , June 17, 2015 ... management solutions, today announced that its U.are.U ® ... Togo,s Eateries, Inc., a ... fast casual sandwich chain, to increase security, improve ... Crossmatch fingerprint readers enable instant, non-repudiable identity confirmation ...
Breaking Biology News(10 mins):NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3
... The National Institute of Neurological Disorders and Stroke (NINDS), ... a three-year, $900,000 grant to the Center for Biomedical ... The grant will fund the center,s biomarker research in ... detect changes in brain function and biochemistry. Led ...
... February 14, 2013 The 18th century natural philosopher ... as a consequence of the cumulative effort, across generations, ... view of evolution was largely abandoned with the advent ... most important traits and many medical illnesses across generations. ...
... assortment of amphibian species living in a pond, the more ... a parasitic infection that can cause severe deformities, including the ... the University of Colorado Boulder. The findings, published ... idea that greater biodiversity in larger-scale ecosystems, such as forests ...
Cached Biology News:NIH funds research to identify Parkinson's biomarkers 2NIH funds research to identify Parkinson's biomarkers 3Life experiences put their stamp on the next generation: New insights from epigenetics 2CU-Boulder amphibian study shows how biodiversity can protect against disease 2CU-Boulder amphibian study shows how biodiversity can protect against disease 3CU-Boulder amphibian study shows how biodiversity can protect against disease 4
(Date:7/3/2015)... 3, 2015 ... osoitteessa  http://www.openinnovationinscience.at Wienissä pidettävään ... Science" -jatkokoulutusohjelmaan 22.7.2015 asti.  ... tekemän, kansainvälisiä tutkijoita ja tiedemiehiä ... suurinta haastetta ovat kannustimien puute ...
(Date:7/3/2015)... Forskere kan søke ... Science", som finner sted i ... på  http://www.openinnovationinscience.at , og søknadsperioden varer frem ... to største utfordringene innen helsevitenskapen er mangelen ... og kompleksiteten av nåværende forskningsresultater, i følge ...
(Date:7/2/2015)... ELLYN, Ill. , July 2, 2015 ... Colton Eakins are gaining invaluable real-world experiences ... of Technology this summer. The students will ... Dr. Jeff Wereszczynski,s research group at IIT. The ... Dr. Tom Carter , Physics; Dr. Kathy ...
(Date:7/2/2015)... ... July 02, 2015 , ... In’Tech Medical SAS ... in Orthopedics, announced today the acquisition of Turner Medical, Inc ., thus ... surgical instruments to the Spine Industry. The acquisition of Turner Medical ideally supplements ...
Breaking Biology Technology:Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 2Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 3Lansering av verdens første Open Innovation-program for utdanning av forskere 2Lansering av verdens første Open Innovation-program for utdanning av forskere 3COD Students Participate in Prestigious Summer Internships 2In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 2In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 3
... Catholic Health Initiatives, (CHI) Institute for Research and ... have announced a joint strategic partnership to focus ... community hospitals across their system. ... clinical R&D and molecular diagnostics laboratory that supports ...
... (Nasdaq: LIFE ), a provider of innovative ... bioenergy crop company, today announced they have completed sequencing the ... SOLiD™ 4.0 System by Life Technologies. The sequence ... crop and advances its development as a high yielding, low-cost ...
... a global leader in material science and high-performance polymer ... 6 languages: English, Chinese, French, German, Japanese, and Spanish. ... Account Managers and modified customer support hours to better ... for download at http://www.zeusinc.com . ...
Cached Biology Technology:BioFortis and Catholic Health Initiatives' Center for Translational Research Announce Biorepository Information Technology Strategic Partnership to Drive Progress in Personalized Medicine 2BioFortis and Catholic Health Initiatives' Center for Translational Research Announce Biorepository Information Technology Strategic Partnership to Drive Progress in Personalized Medicine 3Life Technologies and SG Biofuels Complete Sequence of Jatropha Genome 2Life Technologies and SG Biofuels Complete Sequence of Jatropha Genome 3Life Technologies and SG Biofuels Complete Sequence of Jatropha Genome 4Zeus Catalog Available in Six Languages 2
Homo sapiens postsynaptic protein CRIPT Antigen: Recombinant Protein...
... quadrupole 1200L sets the new standard ... - incorporating the latest technologies and ... chromatography analytical needs. The Atmospheric ... Transmission Quadrupole Analyzer provide superior selectivity ...
Human Legumain Affinity Purified Polyclonal Ab...
Mouse Endoglin/CD105 Fluorescein MAb (Clone 209701)...
Biology Products: