Navigation Links
MDC researchers prevent virus induced myocarditis
Date:4/2/2009

Life-threatening cardiac arrhythmia can be a consequence of myocarditis an inflammation of the cardiac muscle that can be caused by the Coxsackievirus. In mice, Dr. Yu Shi, Chen Chen, and Professor Michael Gotthardt of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, have now abolished the infection by blocking the receptor which is required for virus entry. "We did not detect a single cardiomyocyte that was infected by the virus. Inflammation of the heart muscle associated with this virus infection did not develop," Dr. Shi said. (Journal of American College of Cardiology, 2009; 53:1219-1226, doi:10.1016/j.jacc.2008.10.064).*

The receptor used by the Coxsackievirus to infect the heart is the Coxsackie-adenovirus-receptor (CAR). It can be found in the cell membrane of myocardial fibers. Ulrike Lisewski, Dr. Shi, Michael Radke, and Prof. Gotthardt discovered only recently that CAR is necessary for a regular heart beat.

In their current study, the researchers could demonstrate that genetically engineered mice without CAR were protected from cardiac infection caused by the Coxsackievirus. Moreover, the mice did not show any evidence of inflammatory cardiomyopathy. That is why Professor Gotthardt assumes contrary to previous hypotheses that the direct effects of the virus infection, and not the autoimmune response, primarily determine the disease process.

This distinction is important in order to develop effective methods for future therapies of viral myocarditis. One therapeutic option could be to use CAR as a drug target and to block this receptor with a pharmacological agent.

"However," Dr. Shi explained, "complete blockage of CAR in mice leads to cardiac arrhythmia." Ultimately, the researchers aim to block the receptor transiently, so that only the virus entry is affected without a permanent effect on the heart beat.


'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers examine bacterial rice diseases, search for genetic solutions
2. UC Davis researchers identify a protein that may help breast cancer spread, beat cancer drugs
3. Researchers discover link between schizophrenia and diabetes
4. Cancer Genomics Browser gives cancer researchers a powerful new tool
5. Mayo Clinic researchers discover and manipulate molecular interplay that moves cancer cells
6. Two Hutchinson Center researchers named HHMI Early Career Scientists
7. Tiny but toxic: MBL researchers discover a mechanism of neurodegeneration in Alzheimers disease
8. Researchers develop flow sensors based on hair structures of blind cavefish
9. To fight drug addiction, UB researchers target the brain with nanoparticles
10. Diabetics on high-fiber diets might need extra calcium, report UT Southwestern researchers
11. Researchers find the earliest evidence of domesticated maize
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/11/2017)... NEW BRUNSWICK, N.J. , Jan. 11, 2017  Michael Johnson, ... from Foundation Venture Capital Group, Inc., has been named to the ... Johnson, 27,  was one of 600 people in 20 fields ... only four percent of the 15,000 applicants were selected. ... He is currently a PhD ...
(Date:1/6/2017)... 2017  Delta ID Inc., a leader in consumer-grade ... automotive at CESĀ® 2017. Delta ID has collaborated with ... the use of iris scanning as a secure, reliable ... in a car, and as a way to elevate ... Delta ID and Gentex will demonstrate (booth #7326 ...
(Date:1/3/2017)... VEGAS , Jan. 3, 2017 Onitor, ... the introduction of Onitor Track, an innovative biometric data-driven ... men, showcasing this month at the 2017 Consumer Electronics ... In the U.S., the World Health ... more than two-thirds of adults who are overweight or ...
Breaking Biology News(10 mins):
(Date:1/20/2017)... , January 20, 2017 ... cancer is one of leading causes of death worldwide. ... Although the number of cancer related deaths increased gradually ... Rising in incidence rate of various cancers continues to ... a research report by Global Market Insights, Inc. cancer ...
(Date:1/19/2017)... , Jan. 19, 2017 /PRNewswire -- WuXi AppTec, ... open-access capability and technology platform, today announced that ... biology focused preclinical drug discovery contract research organization ... become a wholly-owned subsidiary of WuXi, and will ... and providing greater services. The acquisition will further ...
(Date:1/19/2017)... Jan. 19, 2017  ArmaGen, Inc., today announced ... Ph.D., as chief executive officer, as well as ... brings to ArmaGen more than 17 years of ... development of biotherapeutics and pharmaceuticals. ... diverse experience and skillset necessary to lead ArmaGen ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... the full spectrum of drug and device development, and Prism Clinical Research ... and clinicians, today announced Verified Clinical Trials (VCT) has been selected ...
Breaking Biology Technology: