Navigation Links
MDC researchers prevent virus induced myocarditis
Date:4/2/2009

Life-threatening cardiac arrhythmia can be a consequence of myocarditis an inflammation of the cardiac muscle that can be caused by the Coxsackievirus. In mice, Dr. Yu Shi, Chen Chen, and Professor Michael Gotthardt of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, have now abolished the infection by blocking the receptor which is required for virus entry. "We did not detect a single cardiomyocyte that was infected by the virus. Inflammation of the heart muscle associated with this virus infection did not develop," Dr. Shi said. (Journal of American College of Cardiology, 2009; 53:1219-1226, doi:10.1016/j.jacc.2008.10.064).*

The receptor used by the Coxsackievirus to infect the heart is the Coxsackie-adenovirus-receptor (CAR). It can be found in the cell membrane of myocardial fibers. Ulrike Lisewski, Dr. Shi, Michael Radke, and Prof. Gotthardt discovered only recently that CAR is necessary for a regular heart beat.

In their current study, the researchers could demonstrate that genetically engineered mice without CAR were protected from cardiac infection caused by the Coxsackievirus. Moreover, the mice did not show any evidence of inflammatory cardiomyopathy. That is why Professor Gotthardt assumes contrary to previous hypotheses that the direct effects of the virus infection, and not the autoimmune response, primarily determine the disease process.

This distinction is important in order to develop effective methods for future therapies of viral myocarditis. One therapeutic option could be to use CAR as a drug target and to block this receptor with a pharmacological agent.

"However," Dr. Shi explained, "complete blockage of CAR in mice leads to cardiac arrhythmia." Ultimately, the researchers aim to block the receptor transiently, so that only the virus entry is affected without a permanent effect on the heart beat.


'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers examine bacterial rice diseases, search for genetic solutions
2. UC Davis researchers identify a protein that may help breast cancer spread, beat cancer drugs
3. Researchers discover link between schizophrenia and diabetes
4. Cancer Genomics Browser gives cancer researchers a powerful new tool
5. Mayo Clinic researchers discover and manipulate molecular interplay that moves cancer cells
6. Two Hutchinson Center researchers named HHMI Early Career Scientists
7. Tiny but toxic: MBL researchers discover a mechanism of neurodegeneration in Alzheimers disease
8. Researchers develop flow sensors based on hair structures of blind cavefish
9. To fight drug addiction, UB researchers target the brain with nanoparticles
10. Diabetics on high-fiber diets might need extra calcium, report UT Southwestern researchers
11. Researchers find the earliest evidence of domesticated maize
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2016)... LONDON , April 26, 2016 ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... a partnership to integrate the Onegini mobile security ... (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The ... enhanced security to access and transact across channels. ...
(Date:4/14/2016)... TEL AVIV, Israel , April 14, 2016 /PRNewswire/ ... in Behavioral Authentication and Malware Detection, today announced the ... has already assumed the new role. Goldwerger,s ... for BioCatch, on the heels of the deployment of ... In addition, BioCatch,s behavioral biometric technology, which discerns unique ...
(Date:3/23/2016)... , March 23, 2016 ... Interesse erhöhter Sicherheit Gesichts- und Stimmerkennung mit ... Inc. (NASDAQ: MESG ), ein ... dass das Unternehmen mit SpeechPro zusammenarbeitet, um ... der Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, im ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... Boston, MA (PRWEB) , ... April 28, 2016 ... ... (EDT), Asymmetrex will deliver a talk on its first-in-class technologies for ... the 2016 Meeting on RNAiMicroRNA Biology to Reprogramming & CRISPR-based Genome ...
(Date:4/27/2016)... ... April 27, 2016 , ... Shimadzu Scientific Instruments (SSI) ... 2016 Marijuana Business Conference and Expo. Shimadzu’s high-performance instruments enable laboratories to test ... Expo attendees can stop by booth 1021 to learn how Shimadzu’s instruments can ...
(Date:4/27/2016)... and RESEARCH TRIANGLE PARK, N.C. ... (NASDAQ: UTHR ) announced today that ... of United Therapeutics will provide an overview and update ... st Annual Health Care Conference. The ... at 10:00 a.m. Eastern Time, and can be accessed ...
(Date:4/27/2016)... ... 27, 2016 , ... A compact PET scanner called NuPET™ ... (Magnetic Resonance Imaging) in existing third-party MRI systems. PET and MRI are complementary ... subjects. Simultaneous PET/MRI imaging offers a solution to many challenges that face researchers ...
Breaking Biology Technology: