Navigation Links
MDC researchers discover molecule responsible for axonal branching
Date:9/21/2009

The human brain consists of about 100 billion (1011) neurons, which altogether form about 100 trillion (1014) synaptic connections with each other. A crucial mechanism for the generation of this complex wiring pattern is the formation of neuronal branches. The neurobiologists Dr. Hannes Schmidt and Professor Fritz G. Rathjen at the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, have now discovered a molecule that regulates this vital process. At the same time they have succeeded in elucidating the signaling cascade induced by this molecule (PNAS, Early Edition, 2009, doi:10.1073)*.

Through the ramification of its fiber-like axon, a single neuron can send branches and thus transmit information into several target areas at the same time. In principle, neurobiologists distinguish between two kinds of axonal branching: branching of the growth cone at the tip of an axon and the sprouting of collaterals (interstitial branching) from the axon shaft.

Both forms of axonal branching can be observed in sensory neurons, which transmit the sensation of touch, pain and temperature, among others. When the axons of these neurons reach the spinal cord, their growth cones first split (bifurcate) and consequently the axons divide into two branches growing in opposite directions. Later new branches sprout from the shaft of these daughter axons which penetrate the gray matter of the spinal cord.

Through investigations on sensory neurons, Dr. Hannes Schmidt and his colleagues were able to identify a protein which triggers the splitting of the growth cone of the sensory axons: the peptide CNP (the abbreviation stands for C-type natriuretic peptide). In transgenic mice the scientists were able to show that CNP is formed in the spinal cord precisely when sensory neurons grow into it. In the absence of CNP bifurcation can no longer occur which results in reduced neuronal connectivity in the spinal cord.

The new findings suppl
'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... Stanford researchers has developed a protein therapy that disrupts ... from original tumor sites, travel through the blood stream ... , This process, known as metastasis, can cause cancer ... of patients who succumb to cancer fall prey to ... associate professor of bioengineering who describes a new therapeutic ...
(Date:9/19/2014)... resource unveiled today by researchers from several Harvard ... provides both experienced and aspiring researchers with the ... operate robots made from soft, flexible materials. , ... cutters, and other advances in manufacturing technology, soft ... Using principles drawn from conventional rigid robot design, ...
(Date:9/19/2014)... A University of Oklahoma biology professor will study ... control leg movements with a National Science Foundation ... four-year project. , Ari Berkowitz, professor in the ... Sciences, will focus on the differences between the ... understand what neurotransmitters they use and what connections ...
Breaking Biology News(10 mins):Stanford researchers create 'evolved' protein that may stop cancer from spreading 2Stanford researchers create 'evolved' protein that may stop cancer from spreading 3Stanford researchers create 'evolved' protein that may stop cancer from spreading 4Soft robotics 'toolkit' features everything a robot-maker needs 2
... of a human brain and squeeze it into a special chamber ... chamber filled with cerebral spinal fluid and thread both of them ... makes the neurons and other brain cells behave as if they ... battery of sensors that monitor how the cells respond when exposed ...
... special issue of ZooKeys , initiated by ... Vladimir Blagoderov bring together 18 papers by 81 authors to ... history collections. Centuries of exploration and discovery have documented ... biodiversity are, for the most part, distributed across varied ...
... discovered the structure and operating procedures of a ... alternative to antibiotics. In research published in ... Science USA, scientists from Monash University, The ... how the bacteriophage lysin, PlyC, kills bacteria that ...
Cached Biology News:Vanderbilt-led team to develop 'microbrain' to improve drug testing 2Vanderbilt-led team to develop 'microbrain' to improve drug testing 3Vanderbilt-led team to develop 'microbrain' to improve drug testing 4Vanderbilt-led team to develop 'microbrain' to improve drug testing 5Bringing natural history collections out of the dark 2New recruits in the fight against disease 2
(Date:9/22/2014)... Follow us on LinkedIn ... has groomed and nurtured anti-aging products and technologies ... on appearance maintenance is benefitting the market for ... obtained from the bacterium, Clostridium Botulinum, which arrests ... With cosmetic indications for botulinum toxin ranging from ...
(Date:9/22/2014)... (Nasdaq: NEOG ) announced today that net ... year, which ended Aug. 31, was $8,883,000 — a ... the first quarter of last year. Adjusted for a ... share in the current quarter were $0.24, compared to ... increased 15% to $67,599,000, from the previous year,s first ...
(Date:9/22/2014)... Olso, Norway (PRWEB) September 22, 2014 ... convenient new parcel and pallet measuring device ... ScanTape™ eliminates manual data entry, offering greater ease ... time savings that result can significantly enhance productivity—an ... in industries where processing volume equals profits. ...
(Date:9/21/2014)... For the first time, scientists have discovered how to ... strength and stiffness greater than that of today,s strongest ... a research team led by John V. Badding, a ... published in the 21 September 2014 issue of the ... point of view, our discovery is intriguing because the ...
Breaking Biology Technology:Strong Demand for Non-Invasive Cosmetic Procedures Drives the Global Botulinum Toxin Market, According to New Report by Global Industry Analysts, Inc. 2Strong Demand for Non-Invasive Cosmetic Procedures Drives the Global Botulinum Toxin Market, According to New Report by Global Industry Analysts, Inc. 3Neogen reports 13% net income increase 2Neogen reports 13% net income increase 3Neogen reports 13% net income increase 4Neogen reports 13% net income increase 5Neogen reports 13% net income increase 6Neogen reports 13% net income increase 7ScanTape™ Handheld Dimensioner Increases Processing Volume 2Smallest possible diamonds form ultra-thin nanothreads 2Smallest possible diamonds form ultra-thin nanothreads 3Smallest possible diamonds form ultra-thin nanothreads 4
... Inc.,(Nasdaq: VTIV ) today announced that Eran ... Officer, will make a presentation at the,2008 UBS ... which will,be held February 11-13, 2008. The conference ... management presentations and,extensive Q&A opportunities., inVentiv,s presentation ...
... Services to Unprecedented Number of ... Elderly and Bariatric Patients, MALVERN, Pa., Feb. 4 ... the first facility in the United,States to install the ... (http://www.usa.siemens.com/healthcare ) -- the,MAGNETOM(R) Verio. Combining 3 Tesla ...
... Chantix and Cialis Lead, Many Heavily Advertised Brands ... Manhattan Research, a leader in,syndicated research and marketing ... the top pharmaceutical branded,product websites ranked by offline ... are based on the comprehensive online consumer,research study ...
Cached Biology Technology:inVentiv Health to Present at the 2008 UBS Global Healthcare Services Conference 2Johns Hopkins Bayview at Forefront of Expanding Access to MRI With First Install of Siemens New MAGNETOM Verio 2Johns Hopkins Bayview at Forefront of Expanding Access to MRI With First Install of Siemens New MAGNETOM Verio 3Manhattan Research Ranks the Top Pharmaceutical Branded Websites by Rx Request Rates 2
GLP expression profiling service on the Affymetrix platform. Starting material can be blood, tissue or RNA. 5 day turnaround. Standard and custom post analyses of microarray data available....
... Microplate Luminometer has been designed,for the ... for,all measurements of glow and flash ... the light remain nearly constant,over a ... as for very fast reactions,requiring at ...
... blotting. Get results sooner and save hours of ... Eliminates the need for a membrane transfer step ... are ready-to-use. No reagents to prepare or mix ... required. Guarantees a simple to perform, mistake-free detection ...
... The EZ-Tn5™ Plasmid-Based Deletion Machine is ... vitro transposition system developed by Goryshin and ... generation of nested families of deletions and ... cloned in a transposon-containing plasmid vector. Although ...
Biology Products: