Navigation Links
MDC researchers develop new tool to investigate ion channels
Date:2/10/2010

Neurotoxins from cone snails and spiders help neurobiologists Sebastian Auer, Annika S. Strzebecher and Dr. Ines Ibaez-Tallon of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, to investigate the function of ion channels in neurons. Ion channels in the cell membrane enable cells to communicate with their environment and are therefore of vital importance. The MDC researchers have developed a system which for the first time allows the targeted, long-lasting investigation of ion channel function in mammals and also the blockade of the ion channels with neurotoxins. In transgenic mice they succeeded in blocking chronic pain by introducing a toxin gene into the organism (Nature Method, doi:10.1038/NMETH.1425)*.

There are approximately 500 species of cone snails, each producing 50 200 different conotoxins. A similar number of peptide toxins are produced by snakes, spiders, sea anemones, scorpions and other venomous animals. The animals use the neurotoxins to paralyze their prey.

Scientists estimate that more than 100,000 neurotoxins exist. They have become a topic of enormous research interest: Using neurotoxins researchers can target different ion channels, receptors and other signaling molecules and characterize their physiological function.

This kind of research can also give them insight into disease processes and eventually help them to find new therapies to eventually block hyperactive ion channels. For instance, a compound (Ziconotide) based on the toxin of a cone snail is already used to treat severe chronic pain in patients.

Dr. Ibaez-Tallon's research group is concentrating on two ion channels in the membrane of neurons which are activated by electric stimulation (action potential). Once activated, they allow the influx of calcium ions into the neuron, and the cell then releases chemicals (neurotransmitters), which send the signal to the next neuron.

During the last decade
'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
MDC researchers develop new tool to investigate ion channels
(Date:7/27/2014)... largest prevalence studies to date, researchers from the U.K. ... the hepatitis C virus (HCV). Findings published in Hepatology, ... of Liver Diseases, indicate that genotype 1 is the ... of which one-third reside in East Asia. Genotype 3, ... most prevalent, followed by genotypes 2, 4, 6, and ...
(Date:7/27/2014)... the potential for global climate change to cut food ... ignored the interactions between increasing temperature and air pollution ... crops. , A new study involving researchers at MIT ... that policymakers need to take both warming and air ... study looked in detail at global production of four ...
(Date:7/27/2014)... patients, scientists have identified more than two dozen ... six that had not been previously reported. The ... partially funded by the National Institutes of Health ... laboratories. , "Unraveling the genetic underpinnings of Parkinson,s ... in this complex disease, and hopefully, may one ...
Breaking Biology News(10 mins):Hepatitis C virus genotype 1 is most prevalent worldwide 2Study: Climate change and air pollution will combine to curb food supplies 2Study: Climate change and air pollution will combine to curb food supplies 3NIH scientists find 6 new genetic risk factors for Parkinson's 2
... temperatures and the ability to conserve water for long periods ... arid parts of the world. But is this global ... the open-access, peer-reviewed journal PLoS ONE April 9, ... Haifa, Israel now show that this is indeed the case, ...
... Calif., April 9, 2009Scientists at Burnham Institute for Medical ... (UC San Diego) School of Medicine have demonstrated in ... the immune system when encapsulated in polytetrafluorethylene (PTFE). The ... 1 diabetes, was published online on April 8 in ...
... if you stare at the downward motion of a waterfall ... appear to drift upward. MIT neuroscientists have found that ... visual perception but also in our tactile perception, and that ... you feel the world can actually change how you see ...
Cached Biology News:Scorpion biodiversity 2Device protects transplanted pancreatic cells from the immune system 2MIT: How you feel the world impacts how you see it 2
(Date:7/28/2014)... (PRWEB) July 28, 2014 The National ... in Muncie IN, is pleased to announce that it ... National Museum of the United States Air Force. , ... year-long process that concluded this spring with an on-site ... Dayton, OH museum. , The National Museum of ...
(Date:7/25/2014)... 2014 "Ischemic Stroke and Cerebral ... data on the Ischemic Stroke and Cerebral Stroke ... and data relating to the clinical trials on ... global Ischemic Stroke Research Report 2014 at: ... the trial numbers and their recruitment status as ...
(Date:7/25/2014)... -- Trillions of bacteria live in each person,s digestive ... digest food and stave off harmful infections, but their ... To help shed light on the role of these ... professor Eric Alm recently tracked fluctuations in the bacterial ... The findings, described in the July 25 issue of ...
(Date:7/25/2014)... 25, 2014 Research and Markets ... Metabolomics Market 2014-2018" report to their offering. ... Metabolomics or Metabonomics is the scientific study ... a new experimental technique that is being widely ... Metabolites are small molecules that are present in ...
Breaking Biology Technology:AMA’s National Model Aviation Museum Granted Full Civilian Museum Certification by the National Museum of the United States Air Force 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 3Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2
... DIEGO, Nov. 2, 2010 Ardea Biosciences, Inc. (Nasdaq: ... been awarded a $733,438 grant from the Department of ... Patient Protection and Affordable Care Act.  Ardea submitted three ... active development, for expenses incurred during 2009 and 2010. ...
... 2010 Vaccinex, Inc. announced today that it has ... under the Qualifying Therapeutic Discovery Project (QTDP) Program to ... monoclonal antibodies, VX15, VX5 and VX35.  The QTDP grant ... by the U.S. Department of Health and Human Services ...
... ... ... var shortURL = ""; BitlyCB.alertResponse = ... the first one. for (var r in data.results) { first_result = data.results[r]; break; } for (var key in first_result) ...
Cached Biology Technology:Ardea Biosciences Awarded a $733,438 Grant from the U.S. Government Under the Patient Protection and Affordable Care Act 2Ardea Biosciences Awarded a $733,438 Grant from the U.S. Government Under the Patient Protection and Affordable Care Act 3NEURO-BIOTECH CORPORATION: Updates and latest developments 2NEURO-BIOTECH CORPORATION: Updates and latest developments 3NEURO-BIOTECH CORPORATION: Updates and latest developments 4NEURO-BIOTECH CORPORATION: Updates and latest developments 5NEURO-BIOTECH CORPORATION: Updates and latest developments 6NEURO-BIOTECH CORPORATION: Updates and latest developments 7NEURO-BIOTECH CORPORATION: Updates and latest developments 8NEURO-BIOTECH CORPORATION: Updates and latest developments 9
... The Mini-PROTEAN 3 Dodeca cell with multi-casting ... of up to 12 mini format handcast (8.3 ... cm) gels. The cell requires 3.4-4.4 L of ... cooling coil that attaches to an external refrigerated ...
...
... has been developed to significantly increase the ... Stability is increased at room temperature ... This product is subjected to 0.2 ... azide. This formulation insures consistently high ...
...
Biology Products: