Navigation Links
MDC researchers develop new tool to investigate ion channels
Date:2/10/2010

Neurotoxins from cone snails and spiders help neurobiologists Sebastian Auer, Annika S. Strzebecher and Dr. Ines Ibaez-Tallon of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, to investigate the function of ion channels in neurons. Ion channels in the cell membrane enable cells to communicate with their environment and are therefore of vital importance. The MDC researchers have developed a system which for the first time allows the targeted, long-lasting investigation of ion channel function in mammals and also the blockade of the ion channels with neurotoxins. In transgenic mice they succeeded in blocking chronic pain by introducing a toxin gene into the organism (Nature Method, doi:10.1038/NMETH.1425)*.

There are approximately 500 species of cone snails, each producing 50 200 different conotoxins. A similar number of peptide toxins are produced by snakes, spiders, sea anemones, scorpions and other venomous animals. The animals use the neurotoxins to paralyze their prey.

Scientists estimate that more than 100,000 neurotoxins exist. They have become a topic of enormous research interest: Using neurotoxins researchers can target different ion channels, receptors and other signaling molecules and characterize their physiological function.

This kind of research can also give them insight into disease processes and eventually help them to find new therapies to eventually block hyperactive ion channels. For instance, a compound (Ziconotide) based on the toxin of a cone snail is already used to treat severe chronic pain in patients.

Dr. Ibaez-Tallon's research group is concentrating on two ion channels in the membrane of neurons which are activated by electric stimulation (action potential). Once activated, they allow the influx of calcium ions into the neuron, and the cell then releases chemicals (neurotransmitters), which send the signal to the next neuron.

During the last decade
'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
MDC researchers develop new tool to investigate ion channels
(Date:9/22/2014)... areas of sea ice melt in the summer and when ... thinner and more reduced. As the Arctic summers are getting ... reduced sea ice in the Arctic will remove less CO2 ... are representative, then sea ice plays a greater role than ... global CO2 budgets", says Dorte Haubjerg Sgaard, PhD Fellow, Nordic ...
(Date:9/21/2014)... of cowpea (black-eyed peas) is a fascinating example of ... fascinating is the story of the scientist behind the ... Legume of the 21st Century to serve as an ... book was recently published by the Crop Science Society ... Agriculture (IITA). , Singh has devoted his life,s work ...
(Date:9/21/2014)... and barnacles secrete very sticky proteins that help them ... by these natural adhesives, a team of MIT engineers ... repair ships or help heal wounds and surgical incisions. ... researchers engineered bacteria to produce a hybrid material that ... bacterial protein found in biofilms slimy layers formed ...
Breaking Biology News(10 mins):Arctic sea ice helps remove CO2 from the atmosphere 2Engineered proteins stick like glue -- even in water 2Engineered proteins stick like glue -- even in water 3
... R.I. [Brown University] The cactus, stalwart of the desert, ... plant communities found the world over. In a paper ... the National Academy of Sciences , Brown University biologists and ... between 5 and 10 million years ago and coincided with ...
... NEW ... in Brazil,s Pantanal and Cerrado regions can benefit both cattle and wildlife, ... , The technique, which has been adapted for a variety of ... periods of time before moving onto other pastures. The result is a ...
... Osama bin Laden,s leadership, al Qa,ida has been one ... responsible for more than 10,000 deaths and injuries in ... http://www.start.umd.edu/start/publications/br/BackgroundReport_AQAttacks.pdf > by the National Consortium for the Study ... of Maryland (START) . "Al-Qa,ida, the terrorist ...
Cached Biology News:Succulent plants waited for cool, dry Earth to make their mark 2Succulent plants waited for cool, dry Earth to make their mark 3Grazing as a conservation tool 2Bin Laden's attacks among the most lethal: UMD study 2
(Date:9/22/2014)... LEXINGTON, Mass. , Sept. 22, 2014 /PRNewswire/ ... GEVA ), a biopharmaceutical company developing ... appointment of Robert Bazemore as Chief ... Patel , President and Chief Executive Officer, Robert ... the company,s lead program, sebelipase alfa for LAL ...
(Date:9/21/2014)... time, scientists have discovered how to produce ultra-thin "diamond ... greater than that of today,s strongest nanotubes and polymers. ... led by John V. Badding, a professor of chemistry ... 21 September 2014 issue of the journal Nature ... our discovery is intriguing because the threads we formed ...
(Date:9/20/2014)... HealthTronics, Inc. , a ... products and services, has signed a distribution agreement ... Corporation for its high precision laser technology. ... invasive, mobile, surgical technology—offering more choices for healthcare ... HealthTronics will make available Clinicon’s FDA-cleared SureLase™ CO2 ...
(Date:9/19/2014)... disease risks, the biological characteristics people care most about ... heightthe textbook example of a complex traitattributes like risk ... genetic and environmental influences, making it challenging to find ... typically mate two individuals that differ in key waysfor ... study their descendents, looking for genes that tend to ...
Breaking Biology Technology:Synageva BioPharma Appoints Robert Bazemore As Chief Operating Officer 2Synageva BioPharma Appoints Robert Bazemore As Chief Operating Officer 3Synageva BioPharma Appoints Robert Bazemore As Chief Operating Officer 4Smallest possible diamonds form ultra-thin nanothreads 2Smallest possible diamonds form ultra-thin nanothreads 3Smallest possible diamonds form ultra-thin nanothreads 4HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 2HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 3Want to link genes to complex traits? Start with more diversity 2
... 2011 Bacterin International Holdings, Inc. (NYSE Amex: ... revolutionary bone graft material and antimicrobial coatings for medical applications, ... Healthcare Conference. The conference will be held at the Four ... Bacterin,s chairman and CEO, Guy Cook, and CFO, John ...
... NEWTOWN SQUARE, Pa., Aug. 24, 2011 Kibow Biotech, ... worldwide licensing and marketing agreement with the current licensing ... a patented, 100% natural, probiotic dietary supplement indicated for ... moderate to severe renal failure. Developed by Kibow, Azodyl™ ...
... generated stem cells from one of the most rapidly progressing ... into the condition as it will enable scientists to model ... certain nerve cells die. Scientists, funded with a 300,000 ... a patient diagnosed with one of the most progressive types ...
Cached Biology Technology:Bacterin International to Present at Stifel Nicolaus 2011 Healthcare Conference on September 8, 2011 2Kibow Biotech, Inc. Secures $2.4 Million Towards Its Human Clinical Trials by Continued Veterinary Licensing Agreement 2Stem cell study offers hope for Parkinson's patients 2
The thermal printer, 120 V, is used to record fluorescence data acquired with the VersaFluor fluorometry systems. The printer includes a cable and power adaptor....
The Econo gradient pump rack is a preassembled rack that is used to hold the components of the Econo gradient pump kits....
... Use this kit to purify genomic DNA from ... by bead beating in a deep well plate using ... This requires a high velocity plate shaker (available through ... to a silica membrane spin filter plate. The DNA ...
... with FAM-Labeled Substrate (green fluorescence; Ex=488 ... serine protease activation • No lysing, ... Kits utilize cell-permeable, fluorescently labeled inhibitors ... chymotrypsin-like activity in whole living cells. ...
Biology Products: