Navigation Links
MDC researcher Zsuzsanna Izsvák receives advanced European research grant
Date:2/16/2012

Dr. Zsuzsanna Izsvk, research group leader at the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, has been named recipient of a European Research Council (ERC Advanced) grant worth EUR 1.94 million for her research on "jumping genes" (transposons). With the aid of the ERC grant, in the next five years she will focus on investigating how mobile DNA elements (transposons) influence the pathogenesis of cancer and other diseases in the human genome. Altogether, nine MDC researchers, including Dr. Izsvk, have received grants of more than one million euros from the ERC.

About half of the human genome consists of transposon-derived sequences. Active transposons can jump to various sites of the DNA, insert themselves into the genome of the host and continue to spread in this way. Due to this characteristic, transposons are also called "jumping genes".

As a consequence of mutations, in the course of time most of these "jumping genes" in the human genome have lost their mobility; only a few are still active. These remnants of transposons were long considered to be without any function. However, latest studies have shown that transposons are by no means "junk DNA", but rather can influence the regulation of genes.

"The human genome is much more complex than previously assumed. In many processes in the body and also in disease, transposons may be the decisive factor," Dr. Izsvk said. "That is why we need to take a closer look at transposons and their influence."

With the ERC grant, Dr. Izsvk wants to explore the influence of transposons under stress conditions that are triggered by environmental influences, such as toxins or heavy metals, and to understand the association between transposon-derived regulatory sequences and human diseases. Furthermore, together with her team, Dr. Izsvk wants to advance the use of artificially produced transposons for gene therapy.

Dr. Izsvk has worked for over twenty years in transposon research. After several years of research at the University of Minnesota in Minneapolis/USA and at the Netherlands Cancer Institute in Amsterdam, the Hungarian researcher joined the MDC in Berlin-Buch in 1999. She has headed the research group "Mobile DNA" since 2004. At an award ceremony in Stockholm that same year she received the European Young Investigator Award (EURYI), endowed with approximately one million euros, for her research on mobile genetic elements.


'/>"/>
Contact: bachtler@mdc-berlin.de
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Related biology news :

1. Wistar Institute researcher receives New Innovator award from NIH
2. NC State researchers get to root of parasite genome
3. Researchers find animal with ability to survive climate change
4. Researchers find an essential gene for forming ears of corn
5. Researchers note differences between people and animals on calorie restriction
6. Researcher working on destruction of chemical weapons
7. Researchers study acoustic communication in deep-sea fish
8. Researchers discover that growing up too fast may mean dying young in honey bees
9. Researchers study how pistachios may improve heart health
10. UI researchers find potentially toxic substance present in Chicago air
11. Researchers develop new self-training gene prediction program for fungi
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/30/2017)... 30, 2017   Invitae Corporation (NYSE: ... information companies, today announced that it will report its ... 2017 guidance on Monday, February 13, 2017, and Invitae,s ... at 4:45 p.m. Eastern / 1:45 p.m. Pacific. ... briefly review financial results, guidance, and recent developments and ...
(Date:1/24/2017)... PHILADELPHIA , Jan. 24, 2017  It ... a baby,s sock that monitors vital signs and ... instance, an infant,s oxygen saturation level drops. But ... undue alarm to parents, with no evidence of ... "These devices are marketed aggressively to parents of ...
(Date:1/18/2017)... 18, 2017  In vitro diagnostic (IVD) companies were ... acquisitions (M&A), and Kalorama Information expects that trend to ... been shifting. Generally, uncertainty in reimbursement and healthcare reform ... has changed the acquisitions landscape. Instead of looking to ... buying partners outside of their home country and also ...
Breaking Biology News(10 mins):
(Date:2/21/2017)... San Francisco, CA (PRWEB) , ... February 21, ... ... is pleased to announce that Dr. Trevor Heritage has joined its executive team ... a revolutionary system designed to provide insights to help improve the diagnosis and ...
(Date:2/21/2017)... (PRWEB) , ... February 21, 2017 , ... ... GMP cell therapy manufacturing facility at its headquarters laboratory in Poway, California. ... utilizing the experience of both in-house personnel and consultants, VetStem constructed and validated ...
(Date:2/21/2017)... a returning partner of the Amgen Tour of California , ... of the men,s and women,s events for the next five editions ... of California will mark the start of ... cycling teams in the world racing from Northern to ... from Heart Disease TM Women,s Race empowered with SRAM ...
(Date:2/21/2017)... 2017   Invitae Corporation (NYSE: NVTA), one ... that members of the company,s management team will present ... Conference on Monday, March 6, 2017 at approximately 4:00 ... Boston, Massachusetts . The live, ... visiting the investors section of the company,s website at ...
Breaking Biology Technology: