Navigation Links
MDC and FMP researchers identify edema inhibitor
Date:4/5/2013

n the renal principal cells and stay there permanently." Once the thirst is quenched, the levels of the hormone AVP are reduced and aquaporin-2 is shuttled back into the interior of the renal cell until it is needed again.

However, if the AVP level is too high, as is the case in patients with chronic heart failure, aquaporin-2 remains permanently in the plasma membrane of the renal principal cell and directs the water continuously from the primary urine into the renal collecting duct principal cells. These cells funnel the excess water into the body tissue. "This process contributes to edema," Dr. Klumann said.

Discovery of how translocation of water channels can be inhibited

How can aquaporin-2 be prevented from settling permanently in the plasma membrane and thus triggering diseases or making them worse? Using a new research approach, the scientists were able to identify an inhibitor which prevents the translocation of the water channel aquaporin-2 into the cell membrane. At the same time they discovered a new regulatory mechanism of water homeostasis at the molecular level.

The researchers used "small molecules", low molecular weight organic compounds, which penetrate well into cells. They tested 17 700 such substances in renal cells and ultimately filtered out a substance that blocks the redistribution of aquaporin-2 to the plasma membrane. The substance (4-acetyldiphyllin) prevents phosphorylation, an important biological and regulatory activation step. In particular, the compound prevents a phosphorylation reaction that is catalyzed by a protein termed protein kinase A. This protein is activated in the signaling cascade that is triggered by AVP in the renal principal cells. In the presence of 4-acetyldiphillin protein kinase A cannot add a phosphate group to aquaporin-2, with the result that the water channels can no longer redistribute to the plasma membrane.

The new research findings may not only be of interes
'/>"/>

Contact: Bachtler, Barbara
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Barrow researchers identify
2. Researchers discover brain cancer treatment using genetic material from bone marrow cells
3. Notre Dame researchers are using new technologies to combat invasive species
4. University of Montreal researchers discover how drug prevents aging and cancer progression
5. Researchers question evaluation methods for protected areas in the Amazon
6. Penn Researchers attach Lyme disease antibodies to nanotubes, paving way for diagnostic device
7. Researchers find novel mechanism regulating replication of insulin-producing beta cells
8. Researchers find novel way plants pass traits to next generation
9. Ludwig cancer researchers honored among first class of fellows in AACR Academy
10. Researchers issue forecast for moderate New England red tide in 2013
11. Researchers spot molecular control switch for preterm lung disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/12/2015)...   MedNet Solutions , an innovative SaaS-based eClinical ... research, is proud to announce that iMedNet ... technology platform, has led the way to significant and ... 2015.   Q2 2015 and Q1 2015 were, respectively, ... value sold in the company,s 15 year history.  In ...
(Date:8/11/2015)... -- Today, ZUK announced its Android smartphone Z1, featuring ... revenues in 2015 that relate to sales of FPC1155 for this ... 2,200 MSEK for 2015. Jörgen Lantto, CEO of FPC, ... smartphone manufacturer in China and we ... 155 for Z1 , ...
(Date:8/6/2015)... Germany , August 6, 2015 ... Instruments (SMI) shows the world,s first Eye ... on Epson,s Moverio BT-200 see-through head mounted display and ... solution, unprecedented quality and efficiency is brought to personalized ... For the first time, professionals and researchers can integrate ...
Breaking Biology News(10 mins):MedNet Solutions Experiences Explosive Corporate Growth 2FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3
... pathway that plays a critical role in the growth ... important insight into the development of the vascular system ... inhibiting the blood vessels that fuel cancers, diabetic eye ... published online on Oct. 14 in Nature Genetics. was ...
... 13, 2007Today at the Prostate Cancer Foundations Annual Scientific ... common foods such as tomatoes and fish, maintaining a ... may help prevent prostate cancer, and help men live ... men will be diagnosed with prostate cancer in their ...
... been awarded to the Intergov-ernmental Panel on Climate Change (IPCC) ... about man-made climate change, and to lay the foundations for ... In particular, the 4th United Nations Climate Report on global ... and May 2007 revealed new facts and has been a ...
Cached Biology News:Study reveals a key to blood vessel growth and possible drug target 2Study reveals a key to blood vessel growth and possible drug target 3Leading researchers to reveal comprehensive dos and don'ts for prostate cancer 2Leading researchers to reveal comprehensive dos and don'ts for prostate cancer 3Nobel Peace Prize 2007 to intergovernmental panel on climate change 2
(Date:9/2/2015)... ... September 02, 2015 , ... The wet ... use of special anti-vascular endothelial growth factor agents given by injection into the ... not have a scientific protocol for the many millions diagnosed with it. AMD ...
(Date:9/2/2015)... -- Biovista Inc. is glad to announce ... science challenge, a global competition hosted by the Rare ... the latest life science innovations and technologies. ... capability to support Steven Laffoon and his ... Niemann-Pick Disease Type A (NPA), a rare and fatal ...
(Date:9/2/2015)... -- Aytu BioScience, Inc. (OTCQB: AYTU), a specialty healthcare ... conditions, announced today that it has closed the final ... raising a total of $5.175 million, which includes proceeds ... Josh Disbrow , Chief Executive Officer of ... to be used to conduct clinical studies for both ...
(Date:9/2/2015)... , September 2, 2015 ... des Wettbewerbs BeHEARD von 2015 bekanntgeben zu können. ... Rare Genomics Institute. Biovista unterstützt mit ... für die Behandlung anderer Krankheiten als denen, für ... Laffoon und sein Team bei der Wylder ...
Breaking Biology Technology:StemCell GeneticMed Announces That It Has Started Stem Cell Treatments for Age Related Dry Macular Degeneration (AMG) 2Biovista Sponsors Wylder Nation Foundation's Research on Acid Sphingomyelinase Deficiency 2Aytu BioScience Completes $5.175 Million Private Placement 2Aytu BioScience Completes $5.175 Million Private Placement 3Biovista sponsert die Forschung von Wylder Nation Foundation zum Thema Mangel an saurer Sphingomyelinase 2
... CHENGDU, China, Oct. 1, 2011 /PRNewswire-Asia-FirstCall/ -- ... or the "Company"), a pharmaceutical company that ... Chinese medicine, branded generics and active pharmaceutical ... of the manufacturing environmental assessment at its ...
... 2011 Life Technologies Corporation (NASDAQ: ... detailing key steps of the Ion PGM™ sequencer ... at the core of Ion semiconductor sequencing are now openly ... as well as scientists that are closely watching the growth ...
... , Troy, N.Y. Waste heat is a byproduct ... driving a car to flying an aircraft or operating ... have developed new nanomaterials that could lead to techniques ... work. The key ingredients for making marble-sized pellets of ...
Cached Biology Technology:JCM Receives the Approval for its Manufacturing Environmental Assessment 2Open Ion Community Fuels Race to Win Three $1M Prizes 2Open Ion Community Fuels Race to Win Three $1M Prizes 3Open Ion Community Fuels Race to Win Three $1M Prizes 4Open Ion Community Fuels Race to Win Three $1M Prizes 5Rensselaer engineers 'cook' promising new heat-harvesting nanomaterials in microwave oven 2
The imaging screen-K (Kodak), tritium, is a 20 x 25 cm storage phosphor screen that is used for the quantitation and imaging of 32P, 33P, 35S, 14C, and 3H....
The filter 695RDF55 Reflect 635 for the Molecular Imager FX is a band pass filter for Cy5 and Alexa Fluor 635 dyes....
The filter 605DF50 for the Molecular Imager FX is a band pass filter for ethidium bromide, SYPRO Red, SYPRO Ruby, Alexa Fluor 532 and 546, and Cy3 dyes when using the 635 nm laser....
... The Model 175 tube gel cell is ... gels for 2-D electrophoresis applications. The upper ... OD tubes 9-23 cm long for isoelectric ... upper buffer chamber and cooling core, lower ...
Biology Products: