Navigation Links
Lyncean Technologies Inc. receives $1.2 M from NCRR to develop new imaging technique
Date:5/11/2009

Lyncean Technologies, Inc. has just received a Phase I SBIR grant of $1,296,403 from the National Center for Research Resources (NCRR) to develop "Differential Phase Contrast Imaging" using the unique x-ray beam produced by the Compact Light Source (CLS). The grant will allow Lyncean to continue its ongoing development of the Compact Light Source and its applications to new methods of imaging (http://www.eurekalert.org/pub_releases/2009-01/lti-fsf010609.php).

The Compact Light Source effort was funded by the National Institute of General Medical Sciences (NIGMS) Small Business Innovation Research (SBIR) program as an advanced technology related to the NIGMS Protein Structure Initiative (PSI). The CLS technology is based on an electron beam stored in a miniature storage ring colliding repeatedly with an opposing infrared light pulse stored in a high-finesse cavity. Each collision produces x-rays through inverse Compton scattering. The entire x-ray source fits in a 10x25 ft room similar in size to those used for Magnetic Resonance Imaging in medical clinics.

The first scientific publication using the CLS x-ray beam employed a technique called Differential Phase Contrast Imaging (DPCI) developed by Professor Franz Pfeiffer (now at TU Munich) and collaborators at the Paul Scherrer Institute in Switzerland (http://journals.iucr.org/s/issues/2009/01/00/issconts.html). DPCI uses a pair of micron-scale gratings to create three images: an absorption image enhanced by the x-ray beam quality, a second image sensitive to the phase of the x-ray wave front, and a third image sensitive to the local scattering power. This technique has been primarily developed at the x-ray beam lines in large synchrotrons, and it relies on a small point-like, monochromatic x-ray source to achieve the coherence necessary for the fringes. The DPCI technique has already demonstrated superior visualization of soft tissue in many publications. The Compact Light Source has an x-ray beam that is a perfect match for the technique.

This new grant will permit the development of an x-ray imaging system called "The Clinical High Resolution Imaging System (CHRIS)" which takes advantage of the unique properties of the CLS x-ray beam. The CLS x-ray beam emerges from a tiny spot (about 100 microns) and diverges in a cone to illuminate first the sample and then the gratings which are specifically designed to produce x-ray fringes. The diverging monochromatic beam already produces very high resolution images and tomography, due to the point-like source and monochromatic x-ray energy (http://www.eurekalert.org/multimedia/pub/11554.php?from=128323). In addition, the gratings permit the creation of the two additional images, using the new phase and scattering contrast mechanisms, which are not possible in conventional radiographs (http://www.eurekalert.org/multimedia/pub/11553.php?from=128323). The combination of these three images can distinguish subtle variations in soft tissue at an extremely fine scale.

When complete, the CHRIS development aims towards a product which will enable the development of clinical applications of this new imaging method towards cancer detection, mammography, osteoarthritis, small animal imaging and other clinical radiological applications which require the detection of fine structure within soft tissue.


'/>"/>

Contact: Ronald Ruth
ronald_ruth@lynceantech.com
650-320-8300
Lyncean Technologies, Inc.
Source:Eurekalert

Related biology news :

1. NIH awards UC $9 million grant to improve patient point-of-care technologies
2. Patent Issued for e-Smart Technologies, Inc.s First Biometric Match-on-Card Technology
3. Titanium Group to Showcase Products and Technologies in Prestigious Government Seminar
4. e-Smart Technologies Responds to Press Release Issued By IDsmart LLC
5. e-Smart Technologies, Inc. Responds to Information Subpoenas From Securities & Exchange Commission
6. e-Smart(R) Technologies, Inc., Announces Next Generation Superthin Polyimide Flexible Circuit Biometric Super Smart Card(TM) card, the i am(TM) Card.
7. Material Technologies Holds First Electrochemical Fatigue Sensor Training for Private Inspection Firms
8. e-Smart(R) Technologies Delivers Its New Super Smart Card(TM) in South Korea.
9. e-SMART Technologies Continues Delivery of Its New Super SMART Card in South Korea
10. Phoenix Technologies and Atmel Collaborate to Create Next-Generation Security Solutions for PCs
11. Atmel and Phoenix Technologies Collaborate to Create Next-generation Security Solutions for PCs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/6/2017)... , Jan. 6, 2017  Privately-held CalciMedica, Inc., ... in healthy volunteers of a novel calcium release-activated ... acute pancreatitis. Acute pancreatitis, sudden ... mild disorder, but can be very serious.  In severe ... sepsis, where extended hospital stays, time in the ...
(Date:1/4/2017)... , Jan. 4, 2017  CES 2017 – ... biometric sensor technology, today announced the launch of ... sensor systems, the highly-accurate biometric sensor modules that ... biometric technology, experience and expertise. The two new ... designed specifically for hearables, and Benchmark BW2.0, a ...
(Date:12/20/2016)... 2016 The rising popularity of mobility ... is stoking significant interest in keyless access systems. ... low energy (BLE), biometrics and near-field communication (NFC) ... of wireless technologies in the automotive industry. This ... access systems opens the market to specialist companies ...
Breaking Biology News(10 mins):
(Date:1/24/2017)... ... 2017 , ... Amendia, Inc., designer, developer, and manufacturer of ... Executive Vice President and Chief Financial Officer. , Steve has over 30 years ... career at Howmedica, Inc., he has since served in various finance, IT, and ...
(Date:1/24/2017)... Switerland (PRWEB) , ... January 24, 2017 , ... ... first commercially available malaria Plasmodium falciparum culture panels with standard concentrations of histidine ... which are available in a range of concentrations from six different malaria strains, ...
(Date:1/24/2017)... (PRWEB) , ... January 23, 2017 , ... ... that supports innovative science through unique partnerships, seeks outstanding early career nominees for ... innovation is critical to meeting the needs of a world in which one ...
(Date:1/24/2017)... CORAL GABLES, Fla. , Jan. 23, 2017 ... interdisciplinary network focused on scientific discovery and solutions, ... is creating the Frost Institutes for Science and ... technology, engineering, and mathematics (STEM) to help solve ... University of Miami President Julio Frenk ...
Breaking Biology Technology: