Navigation Links
Lymph nodes can be key in spreading prion infectivity
Date:9/24/2007

Lymph nodes can be crucial for spreading low doses of infective prion agents -the pathogens responsible for conditions such as scrapie and Creutzfeldt-Jakob disease - into the nervous system, according to new research published in the online open access journal BMC Veterinary Research. While we can show that the regional lymph node plays no pivotal role in the neuroinvasion of prions for high doses of infection, we cannot rule out the possibility that lymph nodes are still involved in the distribution of prions throughout the body to other non-neural tissues.

The research, carried out by scientists in the group of Michael Beekes at the Robert-Koch Institute in Berlin, Germany, sheds new light on the important issue of how prion agents are transmitted from the site of infection to the brain and spinal cord, where they cause irreparable and fatal damage.

Christine Kratzel and colleagues investigated the role of the lymphoreticular system - which comprises the network of lymph nodes that is part of the body's defence system - in the spread of scrapie infection to nerve tissue in hamsters. The team discovered that if a lymph node close to the site of infection is removed within six days after a high or a medium dose of infective agent has been administered, the animal still develops the disease. However, if the node is removed 4 weeks before infection, a high dose causes the disease while a low dose does not (over the course of the 314 day time period for the study). The results suggest that for low doses of infective agent the lymphoreticular system is important in facilitating neuroinvasion i.e. the spread of prions from the infection site to the central nervous system.

The team also noted that after a node had been removed and the wound not yet healed, prion infection is substantially accelerated.

The findings are important because the role of the lymphoreticular system and inflammatory processes in the spread of prion infect
'/>"/>

Contact: Charlotte Webber
press@biomedcentral.com
44-020-763-19980
BioMed Central
Source:Eurekalert

Page: 1 2

Related biology news :

1. Source of molecular triggers in cutaneous T cell lymphoma identified
2. Imaging Lymph Nodes with Nanoparticles
3. Potential Cure for Lymphoma in HIV patients
4. TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas
5. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
6. Reversal of role for a viral protein associated with the development of lymphoma
7. Tadpole soon to help in the fight against cancer and lymphedema
8. Combination therapy improves AIDS-related lymphoma outcome
9. Malaria parasites develop in lymph nodes
10. Antibiotic treats lymphoma of the eye
11. Interaction between lymph and liver cells may affect immune response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... , Dec. 12, 2014 Research and Markets ... the "Global Facial Recognition Market 2015-2019" report ... Facial recognition is a technology used ... the overall facial feature of a person such as ...
(Date:12/11/2014)... 2014  Data Sciences International (DSI), the global leader ... series of digital telemetry implants to meet the ... part of the PhysioTel™ Digital platform, was designed ... data when incorporating functional endpoints into repeat-dose toxicology ...
(Date:12/10/2014)... DIEGO , Dec. 9, 2014 CIE San Diego ... provides the connective tissue that enhances care coordination among social ... client-level information; earned a second $1 million grant from the ... in community and; will be recognized as a "Live Well ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3New telemetry implants expected to change how large animal toxicology studies are conducted 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... a group of human subjects to operate a robot-controlled joystick, ... "learns" to control certain muscle movements, the more likely it ... results, the investigators say, could alter rehabilitation approaches for people ... , In a report on the work in the ...
... and exercise performance measures of trained cyclists at high ... a lot -- up to 45% -- while others ... level. , Ten cyclists who took sildenafil at altitude ... kilometers by 15% compared to placebo trials at altitude. ...
... for breast cancer do not increase their life expectancy ... analysis by researchers from UC Davis, UCSF, the University ... addition, the researchers showed that tamoxifen is an extraordinarily ... per year of life saved. The study will be ...
Cached Biology News:New approach to vaccine development provides potent, long-lasting immunity 2New approach to vaccine development provides potent, long-lasting immunity 3Viagra improves high altitude exercise performance up to 45% for some 2Viagra improves high altitude exercise performance up to 45% for some 3Viagra improves high altitude exercise performance up to 45% for some 4Tamoxifen for breast cancer prevention does not benefit most women 2Tamoxifen for breast cancer prevention does not benefit most women 3
(Date:1/22/2015)... January 22, 2015 Pipette.com has added ... to their comprehensive portfolio of Eppendorf products. , The ... purchase a Centrifuge 5424/5424 R and receive the following:, ... Eppendorf Research plus or Eppendorf Reference 2 , ...
(Date:1/22/2015)... Selexis SA, a serial innovation company with proven ... for drug discovery to commercial manufacturing, announced today all ... Sequencing (NGS) data packages. The NGS analysis of ... the integrity of the gene, validation of the left ...
(Date:1/22/2015)...  Varian Medical Systems (NYSE: VAR ), world leader ... commitment to sustainability with inclusion on a prestigious list of ... healthcare equipment company among the Corporate Knights Global 100 Most ... at Davos, Switzerland . ...
(Date:12/24/2014)... Md. , Dec. 24, 2014  United Therapeutics Corporation ... Inc. (NYSE: MDT ) has submitted a ... Administration (FDA) for the use of Medtronic,s SynchroMed ® ... developed catheter) for use with United Therapeutics, Remodulin ® ...
Breaking Biology Technology:Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Varian Honored Among World's 100 Most Sustainable Corporations 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4
... today announced that it has secured $38 million in ... in 2004, the company has raised $92 million in ... round, which consists of two tranches, was led by ... rata participation of existing investors Apax Partners, Clarus Ventures, ...
... April 7 , - ... Ansell Global Healthcare Educational Program, Accepted,for Accreditation , ... leader in healthcare barrier,protective solutions, has announced it has ... community in the area of continued,education. , ...
... Geographical Society,s awards ceremony on Wednesday, April 15, at ... polar explorers - of this planet and of Mars. ... the gargantuan task of relocating the society,s library, described ... the western hemisphere," from New York to Wisconsin in ...
Cached Biology Technology:Aerovance Secures $38 Million in Equity Financing 2Aerovance Secures $38 Million in Equity Financing 3Ansell Healthcare Espresses Firm Commitment to Support Continued Education of Healthcare Professionals Worldwide 2Ansell Healthcare Espresses Firm Commitment to Support Continued Education of Healthcare Professionals Worldwide 3Ansell Healthcare Espresses Firm Commitment to Support Continued Education of Healthcare Professionals Worldwide 4American Geographical Society awards honor Henson, Smith on April 15 at UD 2American Geographical Society awards honor Henson, Smith on April 15 at UD 3American Geographical Society awards honor Henson, Smith on April 15 at UD 4
Mouse monoclonal antibody to PPP2R2C - protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform...
These 96-well 0.2 ml thin-wall PCR plate caps are caps that are used to seal 96-well, 0.2 ml thin-wall PCR plates. Supplied as 300 caps....
ImmunoPure Plus Immobilized Protein G, , , , Support: Cross-linked 6%, beaded agarose , Capacity: > 20 mg human IgG/ml of gel ...
Mouse polyclonal antibody to ALS2CR8 - amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8...
Biology Products: