Navigation Links
Luteolin stars in study of healthful plant compounds
Date:7/8/2010

This release is available in Spanish.

Natural compounds in plants may protect us against unwanted inflammation. However, human nutrition researchers agree that many questions remain about exactly how these compounds, known as phytochemicals, do that. Studies led by Agricultural Research Service (ARS) molecular biologist Daniel H. Hwang are providing some of the missing details.

Certain kinds of inflammation can increase risk of cancer and of some other disorders, including heart disease and insulin resistance, according to Hwang. He's with the ARS Western Human Nutrition Research Center at the University of California-Davis.

Some of Hwang's on-going studies build upon earlier research in which he and colleagues teased out precise details of how six natural compounds in plants--luteolin, quercetin, chrysin, eriodicytol, hesperetin, and naringenin--apparently act as anti-inflammatory agents.

Luteolin is found in celery, thyme, green peppers, and chamomile tea. Foods rich in quercetin include capers, apples, and onions. Chrysin is from the fruit of blue passionflower, a tropical vine. Oranges, grapefruit, lemons, and other citrus fruits are good sources of eriodicytol, hesperetin, and naringenin.

Hwang's team showed, for the first time, that all six plant compounds target an enzyme known as "TBK1." Each compound inhibits, to a greater or lesser extent, TBK1's ability to activate a specific biochemical signal. If unimpeded, the signal would lead to formation of gene products known to trigger inflammation.

Of the six compounds, luteolin was the most effective inhibitor of TBK1. Luteolin is already known to have anti-inflammatory properties. However, Hwang and his colleagues were the first to provide this new, mechanistic explanation of how luteolin exerts its anti-inflammatory effects.

The approaches that the researchers developed to uncover these compounds' effects can be used by scientists elsewhere to identify additional anti-inflammatory compounds present in fruits and vegetables.


'/>"/>

Contact: Marcia Wood
Marcia.Wood@ars.usda.gov
301-504-1663
United States Department of Agriculture-Research, Education, and Economics
Source:Eurekalert

Related biology news :

1. Study: Sea stars bulk up to beat the heat
2. Australian filmmakers are stars of science film awards
3. Gold nanostars outshine the competition
4. New retrieval method makes studying cancer proteins easier
5. York U autism-related study discovers how drug interferes with neuronal cell function
6. Study sheds light on triglyceride metabolism
7. Study shows cleaner water mitigates climate change effects on Florida Keys coral reefs
8. Terrorist de-radicalization shows promise, comprehensive study finds
9. Air pollution doesnt increase risk of preeclampsia, early delivery, study finds
10. Exploratory study: High BMI linked to proximity to convenience stores
11. Study finds that simple 2-question survey can better identify hungry children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/9/2016)... -- Elevay is currently known as the ... high net worth professionals seeking travel for work   ... there is still no substitute for a face-to-face meeting. ... deal with a firm handshake. This is why wealthy ... citizenship via investment programs like those offered by the ...
(Date:4/28/2016)... , April 28, 2016 First quarter 2016: ... up 966% compared with the first quarter of 2015 ... SEK 589.1 M (loss: 18.8) and the operating margin was 40% ... 0.32) Cash flow from operations was SEK 249.9 M ... revenue guidance is unchanged, SEK 7,000-8,500 M. The operating ...
(Date:4/19/2016)... , UAE, April 20, 2016 ... implemented as a compact web-based "all-in-one" system solution for ... biometric fingerprint reader or the door interface with integration ... modern access control systems. The minimal dimensions of the ... readers into the building installations offer considerable freedom of ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... 2016 Epic Sciences unveiled a liquid ... to PARP inhibitors by targeting homologous recombination deficiency ... new test has already been incorporated into numerous ... types. Over 230 clinical trials are ... including PARP, ATM, ATR, DNA-PK and WEE-1. Drugs ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with ... in this eBook by providing practical tips, tools, and strategies for clinical researchers. ...
(Date:6/23/2016)... June 23, 2016 /PRNewswire/ - FACIT has announced ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" ... commercialization of a portfolio of first-in-class WDR5 inhibitors ... such as WDR5 represent an exciting class of ... precision medicine for cancer patients. Substantial advances have ...
(Date:6/23/2016)... Lawrence, MA (PRWEB) , ... June 23, 2016 ... ... the Peel Plate® YM (Yeast and Mold) microbial test has received AOAC Research ... test platform of microbial tests introduced last year,” stated Bob Salter, Vice President ...
Breaking Biology Technology: