Navigation Links
Luteolin stars in study of healthful plant compounds
Date:7/8/2010

This release is available in Spanish.

Natural compounds in plants may protect us against unwanted inflammation. However, human nutrition researchers agree that many questions remain about exactly how these compounds, known as phytochemicals, do that. Studies led by Agricultural Research Service (ARS) molecular biologist Daniel H. Hwang are providing some of the missing details.

Certain kinds of inflammation can increase risk of cancer and of some other disorders, including heart disease and insulin resistance, according to Hwang. He's with the ARS Western Human Nutrition Research Center at the University of California-Davis.

Some of Hwang's on-going studies build upon earlier research in which he and colleagues teased out precise details of how six natural compounds in plants--luteolin, quercetin, chrysin, eriodicytol, hesperetin, and naringenin--apparently act as anti-inflammatory agents.

Luteolin is found in celery, thyme, green peppers, and chamomile tea. Foods rich in quercetin include capers, apples, and onions. Chrysin is from the fruit of blue passionflower, a tropical vine. Oranges, grapefruit, lemons, and other citrus fruits are good sources of eriodicytol, hesperetin, and naringenin.

Hwang's team showed, for the first time, that all six plant compounds target an enzyme known as "TBK1." Each compound inhibits, to a greater or lesser extent, TBK1's ability to activate a specific biochemical signal. If unimpeded, the signal would lead to formation of gene products known to trigger inflammation.

Of the six compounds, luteolin was the most effective inhibitor of TBK1. Luteolin is already known to have anti-inflammatory properties. However, Hwang and his colleagues were the first to provide this new, mechanistic explanation of how luteolin exerts its anti-inflammatory effects.

The approaches that the researchers developed to uncover these compounds' effects can be used by scientists elsewhere to identify additional anti-inflammatory compounds present in fruits and vegetables.


'/>"/>

Contact: Marcia Wood
Marcia.Wood@ars.usda.gov
301-504-1663
United States Department of Agriculture-Research, Education, and Economics
Source:Eurekalert

Related biology news :

1. Study: Sea stars bulk up to beat the heat
2. Australian filmmakers are stars of science film awards
3. Gold nanostars outshine the competition
4. New retrieval method makes studying cancer proteins easier
5. York U autism-related study discovers how drug interferes with neuronal cell function
6. Study sheds light on triglyceride metabolism
7. Study shows cleaner water mitigates climate change effects on Florida Keys coral reefs
8. Terrorist de-radicalization shows promise, comprehensive study finds
9. Air pollution doesnt increase risk of preeclampsia, early delivery, study finds
10. Exploratory study: High BMI linked to proximity to convenience stores
11. Study finds that simple 2-question survey can better identify hungry children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/9/2017)... MOUNTAIN VIEW, Calif. , March 9, 2017 ... and 23andMe , the leading personal genetics company, ... Zipongo can now provide customers with personalized nutrition plans ... and biometrics, but also genetic markers impacting how their ... Zipongo,s personalized food decision support platform uses biometrics such ...
(Date:3/7/2017)... , March 7, 2017   HireVue , ... top global companies identify the best talent, faster, today ... Chief Sales Officer (CSO) and Diana Kucer ... round out a seasoned executive team poised to drive continued ... building on a year of record bookings in 2017. ...
(Date:3/2/2017)... , March 2, 2017 Summary This ... Perrigo and its partnering interests and activities since 2010. ... Read the ... and Alliance since 2010 report provides an in-depth insight into ... sciences companies. On demand company reports are prepared ...
Breaking Biology News(10 mins):
(Date:3/24/2017)... March 24, 2017 Agenus Inc. (NASDAQ: AGEN), ... antibodies and cancer vaccines, today announced participation at the ...  Annual William Blair and Maidstone Life Sciences conference "Cancer ... in New York, NY . Agenus ... 29 at 9:40 am: Robert B. Stein , ...
(Date:3/23/2017)... 23, 2017  Northwest Biotherapeutics (OTCQB: NWBO) (NW ... therapies for solid tumor cancers, today announced that ... it announced last Friday, March 17, 2017. ... investors securities totaling 28,843,692 shares, comprised of 18,843,692 ... shares of Class C Warrants pre-funded at the ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... ... was recently selected by the Connecticut Technology Council (CTC) as a 2017 Women ... CTC’s thirteenth annual Women of Innovation Awards Dinner. , The dinner recognizes women ...
(Date:3/23/2017)... , March 23, 2017  Agriculture technology company Cool ... financing and note conversion to commercialize its Cool Terra ... focused on developing products that are simultaneously profitable as ... in the last 18 months. This latest round of ... Venture Partners. The company,s primary product, ...
Breaking Biology Technology: