Navigation Links
Lupus gene finding prompts call for more DNA samples
Date:12/2/2007

Wellcome Trust researchers have identified a key gene involved in the disease Lupus, which affects around 50,000 people in the UK, mostly women. The lead researcher behind the study has called for more patients to volunteer DNA samples to enable them to further study the underlying causes of the disease.

Lupus or Systemic Lupus Erythematosus (SLE) is an autoimmune disease which frequently causes skin rash, joint pains and malaise, but can also lead to inflammation of the kidneys and other internal organs. The risk of death in SLE is increased fivefold over that of the general population. However, because the symptoms are often non-specific, diagnosing the condition can be difficult. There is currently no cure for the disease, which can be triggered by viral infections, sunlight, trauma or stress, as well as puberty and childbirth.

In research published online today in the journal Nature Genetics, Professor Tim Vyse from Imperial College London, and colleagues in the US and Canada, have identified a new genetic variant, OX40L, which increases the risk of developing Lupus. The variant, which is carried by one in six people in the UK, increases the risk of developing the disease by 50% per copy.

"Lupus can be a very serious condition, but because its symptoms are often similar to those of other illnesses, it can be difficult and take time to diagnose," says Professor Vyse, a Wellcome Trust Senior Fellow from Imperial College. "Although it appears to have a number of environmental triggers, we are now beginning to get a clearer picture of the role that genetics also plays in the disease."

OX40L is a gene that is important in several different types of cells in the immune system. The work, carried out by members of Prof Vyses laboratory, shows that the genetic variants in the OX40L gene that amplify the risk of lupus do so by increasing the amount of OX40L present on the surface of lymphocytes, which are key components of the
'/>"/>

Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study identifies genetic risk factor for rheumatoid arthritis, lupus
2. Lupus Research Institute strategy delivers $30 million in national funding
3. Finding that 1-in-a-billion that could lead to disease
4. First finding of a metabolite in 1 sex only
5. Embryonic stem cell strategy advanced with UCSF finding
6. New prostate cancer research findings
7. Reprogramming the debate: stem-cell finding alters ethical controversy
8. Safe water: simpler method for analyzing radium in water samples cuts testing time
9. Computer program traces ancestry using anonymous DNA samples
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... has been published in the Scientific Reports journal. ... Biology (a joint centre of CSIC and Pompeu Fabra University-UPF), ... decoded and we saw that it did not match with ... to sequence the complete genome and to make a functional ... belong to Louis XVI". , The functional genome analysis ...
(Date:4/24/2014)... representing the largest study of animal intelligence to-date finds that ... , Published this week in the journal Proceedings of ... of a long history of research aimed at understanding the ... things like make and use tools, read social cues, or ... now, most studies of animal intelligence have focused on only ...
(Date:4/24/2014)... WASHINGTON, April 24A droplet of clear liquid can bend ... well-known phenomenon, researchers have developed a new process to ... than a penny apiece. , Because they,re so ... of applications, including tools to detect diseases in the ... and microscopes for education in classrooms. , "What ...
Breaking Biology News(10 mins):The blood preserved in the pumpkin did not belong to Louis XVI 2Animals with bigger brains, broader diets have better self control 2Animals with bigger brains, broader diets have better self control 3Bake your own droplet lens 2Bake your own droplet lens 3
... An Arizona State University research team has developed a ... renewable biofuels. The team has programmed a photosynthetic ... their biofuel byproducts--easier and potentially less costly. ... harvesting the goodies and turning them into fuel," said ...
... diffraction is a step closer to fulfilling its ... biological samples. In the Proceedings of the ... in applying an approach to "lensless" X-ray microscopy ... produced the first images, using this technique, of ...
... For more than 400 years, scientists have studied ... how these creatures routinely repair injuries that would usually ... Now, fueled by a highly competitive National Institutes ... multi-institutional team of researchers associated with the University of ...
Cached Biology News:Self-destructing bacteria improve renewable biofuel production 2Self-destructing bacteria improve renewable biofuel production 3Researchers demonstrate nanoscale X-ray imaging of bacterial cells 2$2.4 million stimulus fuels effort to regenerate injured spinal cords 2$2.4 million stimulus fuels effort to regenerate injured spinal cords 3$2.4 million stimulus fuels effort to regenerate injured spinal cords 4
(Date:1/15/2014)... JOLIET, Ill. , Jan. 15, 2014  Bill Jacobs Automotive, ... , is teaming up with the Heartland Blood Center ... annual blood drive. The drive takes place Saturday, Jan. 18 ... a.m. - 2 p.m. (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  ...
(Date:1/15/2014)... 15, 2014 Look inside the new ... for the lab, from fluid handling to instruments to ... ship when you order. , Preferred Solutions features ... from the L/S® model for precise flow control and ...
(Date:1/15/2014)... ­ RedBrick Health , a fast-growing leader in ... that EmblemHealth , the New York ... providing the RedBrick Compass health assessment, combined with the ... its members. EmblemHealth is among the first health plans ...
(Date:1/15/2014)... January 15, 2014 More than 5 ... about 1 in 3 seniors will die with Alzheimer’s ... These jaw-dropping figures have shocked many Americans into looking ... help prevent these tragic age-related cognitive disorders. Jonathan Weisman, ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2
... ARBOR, Mich., Sept. 13 MichBio, the ... its 2007/8 Michigan Life,Sciences Directory and Resources ... sciences companies. The guide includes editorial pages ... the University,Research Corridor, the Michigan Universities Commercialization ...
... Mo. and FREDERICK, Md., Sept. 13 /PRNewswire-USNewswire/,-- To ... services,Midwest Research Institute (MRI) announced today the launch ... -- a center staffed by an,internationally recognized team ... to provide a diverse range of specialized,laboratory consulting ...
... Multiplexing Technology Symposium Brings Together Thought Leaders,in Life ... Best Practices, OOSTERHOUT, Netherlands, Sept. 13 ... in multiplexed solutions,today announced the agenda for Planet ... symposium. The two-day event will be,held 2-3 October ...
Cached Biology Technology:Midwest Research Institute Launches Center for Biological Safety and Security (CBS2) 2Luminex Corporation Hosts the Fifth Annual Planet xMAP Europe 2007 Symposium 2Luminex Corporation Hosts the Fifth Annual Planet xMAP Europe 2007 Symposium 3
... Multipeptide Kit, designed for use with ... variety of amyloid peptides more straightforward ... Clinical neuroscience proteomics applications - Monitor ... Correlate beta-amyloid peptide levels with disease ...
... hybridization chamber assembly (1 each) Components ... chamber user guide plastic tweezersChambers are ... cleaned and reused. The chamber is designed ... kits and all custom oligo microarrays, in ...
... Formula variant: With the ... described by Hoagland and ... Equivalency: Formulated to contain ... powder per liter of ...
... For separation and fractionation of ... of nuclei from cytosolic proteins ... complexity, greatly facilitating study of ... nucleic acid binding proteins (e.g., ...
Biology Products: