Navigation Links
Lupus gene finding prompts call for more DNA samples
Date:12/2/2007

Wellcome Trust researchers have identified a key gene involved in the disease Lupus, which affects around 50,000 people in the UK, mostly women. The lead researcher behind the study has called for more patients to volunteer DNA samples to enable them to further study the underlying causes of the disease.

Lupus or Systemic Lupus Erythematosus (SLE) is an autoimmune disease which frequently causes skin rash, joint pains and malaise, but can also lead to inflammation of the kidneys and other internal organs. The risk of death in SLE is increased fivefold over that of the general population. However, because the symptoms are often non-specific, diagnosing the condition can be difficult. There is currently no cure for the disease, which can be triggered by viral infections, sunlight, trauma or stress, as well as puberty and childbirth.

In research published online today in the journal Nature Genetics, Professor Tim Vyse from Imperial College London, and colleagues in the US and Canada, have identified a new genetic variant, OX40L, which increases the risk of developing Lupus. The variant, which is carried by one in six people in the UK, increases the risk of developing the disease by 50% per copy.

"Lupus can be a very serious condition, but because its symptoms are often similar to those of other illnesses, it can be difficult and take time to diagnose," says Professor Vyse, a Wellcome Trust Senior Fellow from Imperial College. "Although it appears to have a number of environmental triggers, we are now beginning to get a clearer picture of the role that genetics also plays in the disease."

OX40L is a gene that is important in several different types of cells in the immune system. The work, carried out by members of Prof Vyses laboratory, shows that the genetic variants in the OX40L gene that amplify the risk of lupus do so by increasing the amount of OX40L present on the surface of lymphocytes, which are key components of the
'/>"/>

Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study identifies genetic risk factor for rheumatoid arthritis, lupus
2. Lupus Research Institute strategy delivers $30 million in national funding
3. Finding that 1-in-a-billion that could lead to disease
4. First finding of a metabolite in 1 sex only
5. Embryonic stem cell strategy advanced with UCSF finding
6. New prostate cancer research findings
7. Reprogramming the debate: stem-cell finding alters ethical controversy
8. Safe water: simpler method for analyzing radium in water samples cuts testing time
9. Computer program traces ancestry using anonymous DNA samples
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... Research Careers) Program has announced the travel award recipients ... 18 22, 2014 in San Diego, California. ... students, post doctorates and scientists from underrepresented groups into ... encourage the participation of young scientists at the American ... 16 awards totaling $29,600., The FASEB MARC Program is ...
(Date:8/28/2014)... The support of peer groups and clinicians ... programs, according to recent University of Georgia research. ... the Athens-Clarke County area determined that role models ... of mothers of infants. , "Mothers who received ... at breastfeeding," said study co-author Alex Anderson, an ...
(Date:8/28/2014)... FASEB MARC (Maximizing Access to Research Careers) ... the American College of Sports Medicine,s Conference on ... in Miami, Florida. These awards are meant ... and scientists from underrepresented groups into the mainstream ... the participation of young scientists at the American ...
Breaking Biology News(10 mins):Breastfeeding study shows need for effective peer counseling programs 2
... Durham, NC The most toxic, brightly colored members of ... says a new study. So-named because some tribes use ... frogs of the Amazon jungle are well known for their ... forest frogs serve to broadcast their built-in chemical weapons: ...
... project to develop and evaluate new tools to control ... a five year, 12 million project involving sixteen partners ... Seventh Framework programme. Because malaria is transmitted by ... disease. Wide scale use of insecticides on bednets ...
... laboratory discoveries into daily clinical practice is important, but ... to the laboratory, to further explore and explain clinically ... basic researchers to understand and address clinical challenges and ... integrate and use new technologies. The key towards ...
Cached Biology News:Fitness tests for frogs? 2€12 million ($16.9 million) project to develop new tools for malaria control 2
(Date:8/28/2014)... , Aug. 28, 2014  Next month, executives from ... three key industry events beginning with Patient-Centered Clinical Trials ... in Boston , September 4-5. Patient recruitment ... and Aaron Fleishman will share insights on the ... a variety of tactics – from media to mobile apps ...
(Date:8/28/2014)... new work by a Florida State University research team ... take your temperature, emit white light, and convert photon ... looks like a butterfly. , Biwu Ma, associate professor ... the FAMU-FSU College of Engineering, created the molecule in ... to discover that his creation has many other unique ...
(Date:8/28/2014)... PrimeSource Building Products, Inc., a leading ... to support their communication needs with the ... conferencing platform GlobalMeet powered by SoundConnect. The solution ... SoundConnect delivers award winning “results driven” business class ... be utilizing GlobalMeet powered by SoundConnect ...
(Date:8/27/2014)... 2014 Green & Grow Inc. (GGI) ... funding and secured Otter Capital as a significant new ... commercialization of GGI’s Agriplier™ technology, building on recent compelling ... “Since our first meeting, we have been impressed with ... space,” said Alan Sobba, President and CEO of GGI. ...
Breaking Biology Technology:BBK Worldwide Leads Sessions at Key September Events 2Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2PrimeSource Chooses SoundConnect as Collaboration Provider 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3
... LINCOLN, Neb., Aug. 20 LI-COR announces its second,webinar ... in In Vivo Imaging: Near Infrared Optical Imaging of ... CDT., Near-infrared (NIR) fluorescence offers dramatic benefits for ... depth of penetration and,decreased autofluorescence and light scatter that ...
... 20 MedPredict, a global,provider of pharmaceutical competitive ... providing critical strategic insight for pharma,and biotech companies ... sclerosis,(MS) therapies., Biogen/Elan,s Tysabri has been under ... a rare and potentially fatal brain disease,associated with ...
... Joseph F. Finn, Jr.,C.P.A. ("Finn"), Assignee of the assets ... today that all pharmaceutical,intellectual property will be sold at ... of the pieces of intellectual property for sale is ... of a,branded drug that currently has more than $2 ...
Cached Biology Technology:LI-COR August 27th On-Line Webinar Introduces New Approach to Small Animal In Vivo Imaging 2Expert Neurology Panel Weighs Impact of New Reports of PML in Multiple Sclerosis Patients on Tysabri 2Spherics, Inc. Successful Bidder May Make MHRA Submission 2
Eppendorf tube holder, for Tube rack 175 x 12 mm, 100. Category: Chromatography Systems & Accessories, Systems....
... Alkaline Phosphatase, Calf Intestinal (CIAP), catalyzes ... RNA, and ribo- and deoxyribonucleoside triphosphates. This ... religation of linearized cloning vector DNA by ... may also be used for the dephosphorylation ...
Agarose, pulse field, 100 g. Nuclease-free.Gel point (1.5%): 36 1.5 C, EEO (-mr): 1800 g/cm2. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Molecular Biological Resources has extensive abilities cloning and expression of prokaryotic and eukaryotic proteins. Please contact lloconne@molbiores.com to discuss your project. Contact lloconne@...
Biology Products: