Navigation Links
Lung airway cells activate vitamin D and increase immune response
Date:11/3/2008

the airway cells helps convert the storage form of vitamin D into its active form.

"When we put the storage form of vitamin D on the lung airway cells, we saw them convert it to the active form," Hansdottir said. "The next step was to investigate whether this active form could affect the expression of genes."

The team then showed that vitamin D activated by airway cells affects two genes involved in immune defense. One gene expresses a protein called cathelicidin that can kill bacteria. The second gene, called CD14, produces a protein that helps cells recognize different kinds of pathogens that could be a threat.

"Vitamin D converted by the kidneys circulates in the bloodstream, but vitamin D converted by other organs appears to stay within those organs and protect them from infection," Hansdottir said. "We were able to see this happen in cells lining the trachea and main bronchi."

The team also found that when lung airway cells are infected by a virus, they express more of the enzyme that activates vitamin D. Hansdottir said the team is very interested in pursuing studies on the role of viral infections in vitamin D production and subsequent effects on lung infections.

"Vitamin D not only increases proteins involved in bacterial killing but also can dampen inflammation," Hansdottir said. "Controlling inflammation through vitamin D is good because too much inflammation can cause problems such as sepsis and seems to contribute to autoimmune disease."

Hansdottir noted that vitamin D insufficiencies and deficiencies (which are more severe) are fairly common, particularly for people living in northern latitudes. While vitamin D can be generated through sun exposure, such exposure is generally not recommended as a remedy because of skin cancer risks. Instead, supplements can be used.

The American Academy of Pediatrics recently recommended that the vitamin D dosage for children be increased to 400 IU (inte
'/>"/>

Contact: Becky Soglin
becky-soglin@uiowa.edu
319-335-6660
University of Iowa
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Franklin Square to study airway bypass procedure for severe emphysema
2. Researchers at Sarasota Memorial Health Care System to study airway bypass treatment for emphysema
3. Positive results for airway bypass
4. New method provides panoramic view of protein-RNA interactions in living cells
5. Simple chemical procedure augments therapeutic potential of stem cells
6. Researchers at UH explore use of fat cells as heart attack therapy
7. Mediator in communication between neurons and muscle cells found
8. JDRF to provide $1M in funding to SmartCells, Inc.
9. Seemingly suicidal stunt is normal rite of passage for immune cells
10. Swamping bad cells with good in ALS animal models helps sustain breathing
11. Forsyth scientists trigger cancer-like response from embryonic stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... Consortium Ltd.,s nanotechnology expert will present a poster ... at the 7th International Nanotoxicology Congress to ... , Dr. Monita Sharma will outline a strategy consistent ... of Sciences, " Toxicity Testing in the 21st Century: ... of non-animal methods involving human cells and cell lines ...
(Date:4/22/2014)... for Experimental Biology (FASEB) has released updated factsheets ... from the National Institutes of Health (NIH) benefits each ... is pleased to make these factsheets available to help ... their state," said FASEB President, Margaret K. Offermann, MD, ... research funding, investing $29.2 billion in FY 2013 ...
(Date:4/22/2014)... of breeding bird surveys sent in by citizen scientists ... years, wildlife researchers report that most of the 40 ... higher elevation in response to climate change, but did ... previous studies of potential climate change impacts on wildlife ... have likely underestimated the effects of environmental warming, say ...
Breaking Biology News(10 mins):Wildlife response to climate change is likely underestimated, experts warn 2
... especially in intensive production. Piglets commonly become susceptible to ... to losses of 10% or more. The antibiotics used ... have now fallen out of use, mainly due to ... A radical solution has been found by using a ...
... cushy haploid environs to take up residence in a ... but Indiana University Bloomington scientists report in this week's ... plants. , "Plants that reproduce clonally or are ... mitochondrion to the nucleus," said graduate student Yaniv Brandvain, ...
... that help shape our understanding of how tool use ... chimpanzees, at least under some conditions, are capable of ... The work, reported by Jill Pruetz of Iowa State ... will appear online in the journal Current Biology on ...
Cached Biology News:A healthier start to a pig's life 2Mitochondrial genes move to the nucleus -- but it's not for the sex 2Chimpanzees found to use tools to hunt mammalian prey 2
(Date:1/15/2014)... (PRWEB) January 15, 2014 DTS Language ... its Online Web Portal for Life Science organizations who need ... specify the subject matter of their documents in advance with ... help reduce time-to-delivery of translations, often a critical factor in ...
(Date:1/15/2014)... 2014 Freeslate, Inc ., the ... that Lupin Limited, one of India’s top five pharmaceutical ... PharmD System for high throughput solid form screening. ... on a wide range of quality, affordable generic and ...
(Date:1/15/2014)... TaiGen Biotechnology Company, Limited ("TaiGen") today announced that ... leading Russian pharmaceutical company, to develop and commercialize nemonoxacin ... , Turkey and other ... novel antibiotic for the treatment of bacterial infections including ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Carahsoft and ... Thursday, January 23, 2014 at 2pm EST (11am PST), ... The topic focuses on how technology can turn raw, ... decisions for government agencies. The online webinar will last ...
Breaking Biology Technology:DTS Improves Efficiency for Life Science Document Translations 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2
... offers revolutionary orthotic prescription ... ... Technologies will,debut the new Xtremityscan System and give away a free ... at the,Disneyland Hotel., Xtremityscan is a digital shape acquisition system ...
... ... Laboratories, NEW YORK, ... that its Owlstone Nanotech Inc.,("Owlstone") subsidiary has received a purchase order ... IEE, an,innovative developer of specialized sensing systems with a global,leadership position ...
... Genaera,Corporation (Nasdaq: GENR ) today announced that Jack ... present at the BIO,Business Forum. The presentation will provide an ... San Diego Convention Center in San,Diego on Tuesday, June 17, ... will also join a panel of experts to discuss new ...
Cached Biology Technology:PAL Health Technologies Debuts Xtremityscan System at Western Podiatric Medical Congress 2Advance Nanotech's Owlstone Subsidiary Receives Order From IEE 2Advance Nanotech's Owlstone Subsidiary Receives Order From IEE 3Advance Nanotech's Owlstone Subsidiary Receives Order From IEE 4Genaera Corporation to Present at BIO Business Forum 2Genaera Corporation to Present at BIO Business Forum 3
... Vybrant Apoptosis Assay Kit #4 ... that occur in the permeability of cell ... both YO-PRO-1 and propidium iodide nucleic acid ... plasma membranes of apoptotic cells and labels ...
Request Info...
Services include subcloning into an expression vector. Tagged protein will be expressed in small scale for testing yield and solubility and then in 1L culture for large scale affinity purification. E...
Request Info...
Biology Products: