Navigation Links
Lowering your cholesterol may decrease your risk of cancer
Date:2/23/2009

Boston, MA Current research suggests that lowering cholesterol may block the growth of prostate tumors. The related report by Solomon et al, "Ezetimibe Is an Inhibitor of Tumor Angiogenesis," appears in the March 2009 issue of The American Journal of Pathology.

High cholesterol not only leads to atherosclerosis and heart disease, but may also contribute to cancer growth and progression. Prostate cancer is the most common non-skin cancer in the United States, affecting approximately 1 in 6 men. Prostate tumors accumulate high levels of cholesterol, and tumor incidence correlates with eating a high fat/high cholesterol diet "Western" diet. In addition, prostate tumor progression has been linked to serum cholesterol levels.

To examine the role of high cholesterol in prostate cancer, Dr. Keith Solomon and colleagues fed mice a high fat/high cholesterol "Western" diet. They found that high cholesterol levels promoted tumor growth and that Ezetimibe (Zetia), which blocks the absorption of cholesterol from the intestine, could prevent this increased tumor growth. Ezetimibe also blocked a cholesterol-mediated increase in angiogenesis, the growth of new blood vessels required for tumor progression. These data suggest that reducing cholesterol levels may inhibit prostate cancer growth specifically by inhibiting tumor angiogenesis.

The article from Solomon et al suggests "that cholesterol reduction, which is routinely accomplished pharmacologically in humans, may reduce angiogenesis, ultimately leading to less aggressive tumors." "Lowering cholesterol levels whether through diet, exercise, or the use of safe cholesterol-lowering drugs is known to provide a substantial benefit to patientsin the future it may be possible to add reduced risk of serious prostate cancer to that list of benefits" says Solomon. "We are in the process of working with clinicians to translate these findings into potential human studies. If we can demons
'/>"/>

Contact: Angela Colmone
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Flowering plants speed post-surgery recovery
2. Extreme weather postpones the flowering time of plants
3. Cholesterol-lowering drugs and the effect on muscle repair and regeneration
4. UT Knoxville professor finds unexpected key to flowering plants diversity
5. University of Alberta researchers report breakthrough in lowering bad cholesterol, fatty acid levels
6. Tree of life for flowering plants reveals relationships among major groups
7. UF botanists: Flowering plants evolved very quickly into 5 groups
8. Hypertension and cholesterol medications present in water released into the St. Lawrence River
9. New genes present drug targets for managing cholesterol and glucose levels
10. Researchers learn that some good cholesterol isnt good enough
11. A scientific breakthrough on the control of the bad cholesterol
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... and Mary,s Virginia Institute of Marine Science have ... Protection Agency to identify the streams and wetlands ... tools to help local governments and citizens conserve ... on a dataset of tidal-marsh observations first gathered ... this historical baseline can today,s researchers accurately map ...
(Date:10/16/2014)... are anything but sustainable: environmental damage to soil ... increasingly evident. Despite their disadvantages, however, monocultures remain ... the sole possibility of achieving higher yields in ... an ecology professor at the University of Zurich, ... forestry. After all, a new study carried out ...
(Date:10/16/2014)... -- NXT-ID, Inc. (NASDAQ: NXTD and ... focused on the growing mobile commerce market announces that ... Smart Wallet, at the 13 th annual Future ... conference on the intersection of technology and the economy. ... founder and publisher of the Strategic News Service™, the ...
Breaking Biology News(10 mins):EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3
... David Schindler has reviewed data from studies of controlling ... input of the nutrient phosphorus is the key to ... controlling the human input of both nitrogen and phosphorus ... blooms., In contrast, Schindler concluded that only phosphorus control ...
... new study by researchers from the Global Change Institute ... Excellence for Coral Reef Studies at James Cook University, ... managed marine protected areas within Fiji are playing an ... inshore habitats. , The study estimates that by ...
... Fred Hutchinson Cancer Research Center, has been honored ... expert in virology, immunology and vaccine development, Corey,s ... viral infections, particularly those associated with cancer. "Corey,s ... of daily antiviral treatment for immunocompetent persons," explains ...
Cached Biology News:In Fiji, marine protection gets local boost 2The American Society for Microbiology honors Lawrence Corey 2The American Society for Microbiology honors Lawrence Corey 3
(Date:10/25/2014)... TX (PRWEB) October 24, 2014 Today, ... products, announced the winners of its “Reflect Your Youth” ... have not only seen a difference in their skin ... experienced a new outlook on life as a result ... contest originated as an effort by Nerium International to ...
(Date:10/25/2014)... , October 24, 2014 Oramed ... pharmaceutical company focused on the development of oral drug ... Nadav Kidron will present at FireRock Capital,s Micro-Cap ... Annual Micro-Cap Conference ,Date: Tuesday, October 28, 2014 ,Time: ... New York City , ...
(Date:10/25/2014)... Research and Markets has announced ... , Research Area & by End User - Global ... In this report, the global epigenetics market ... and end users. The product segments of the epigenetics ... consumables, kits, and reagents. The subsegments of the enzymes ...
(Date:10/22/2014)... , Oct. 22, 2014  Actavis plc (NYSE: ... company, and Rhythm, a biopharmaceutical company, today announced that ... Rhythm,s wholly owned subsidiary, Rhythm Health, Inc., which is ... treatment of diabetic gastroparesis and other GI functional disorders. ... 2 trial of relamorelin for the treatment of diabetic ...
Breaking Biology Technology:Nerium International™ Inspires Conversation About the Journey of Aging with “Reflect Your Youth” Contest 2Oramed to Present at the FireRock Annual Micro-Cap Conference 2Oramed to Present at the FireRock Annual Micro-Cap Conference 3Global Epigenetics (VLA, WBA, NBA, RTA, Rotary-Wing Aircraft) Market - Forecast to 2019 2Global Epigenetics (VLA, WBA, NBA, RTA, Rotary-Wing Aircraft) Market - Forecast to 2019 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 2Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 4Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 5
... News Facts, , ... life sciences industry -- including,biopharmaceutical companies, contract ... increasingly turning to Oracle(R) Remote,Data Capture (RDC) ... effectively. , , -- ...
... Mealey,s Conferences (now HB,Litigation Conferences) released its upcoming schedule ... for women in the legal profession. , , ... 22 - Asbestos Gaskets: Exposure and the State of the ... , February 5 - Nanotechnology: ...
... Jan. 20 Amgen (Nasdaq: AMGN ) today ... full year financial results on Monday, Jan. 26, 2009 after ... followed by a conference call with the investment community at ... Amgen will be Kevin Sharer, chairman and chief executive officer, ...
Cached Biology Technology:Life Sciences Organizations Choose Oracle to Accelerate and Simplify Clinical Trial Data Collection 2Life Sciences Organizations Choose Oracle to Accelerate and Simplify Clinical Trial Data Collection 3Life Sciences Organizations Choose Oracle to Accelerate and Simplify Clinical Trial Data Collection 4Asbestos, Pharmaceutical Liability, Construction Defects, Nanotech: Covered by Targeted CLE Teleconferences 2Amgen Announces Webcast of 2008 Fourth Quarter and Full Year Financial Results 2
... number is a new product ... Cornings product number. If showing ... under the old Sigma-Aldrich number ... for assistance. ID clarifier: box ...
... 96-well Cell Invasion Assay is designed to ... laminin as a significant barrier to invasion ... vitro in a convenient, high-throughput, 96-well format. ... for all types of adherent cells such ...
... The GrabIt™ Kits are designed for the ... using a pull-down method. Proteins that interact ... fusion proteins are copurified using affinity ... are retained on a spin filter. The ...
Kit containing MACS equipment and reagents for immunopurification of proteins....
Biology Products: