Navigation Links
Low sperm count may be associated with prenatal testosterone excess
Date:9/23/2008

Exposure to an excess of sexual steroids, like testosterone, during fetal development may be a potential risk factor for low sperm count and motility, according to a new study accepted for publication in Endocrinology, a journal of The Endocrine Society.

"The majority of disorders affecting sperm count in humans are originated during fetal life," said Professor Sergio Recabarren of the University of Concepcion in Chillan, Chile and lead author of the study. "A developing fetus is very vulnerable to its environment, and when that environment is exposed to excess sexual steroids, it may have a significant deleterious effect on a male offspring's fertility."

Prenatal exposure to excess sexual steroids can occur in two ways, said Dr. Recabarren. First, the exposure may be a product of increased sexual steroids in the maternal environment due to a hormonal condition such as polycystic ovary syndrome. Second, humans are exposed to several industrial pollutants which can act as steroid mimics, causing the body to inhibit or accelerate native steroid production.

In this study, researchers treated pregnant sheep with 30 mg testosterone propionate twice weekly from days 30 to 90 of pregnancy and with 40 mg testosterone propionate from days 90 to 120 of pregnancy. They found a significant reduction in body weight, scrotal circumference, and sperm count in male sheep born to these mothers compared with control sheep.

"While this research involved sheep, it can certainly be argued that in humans, exposure to an excess of sexual steroids during fetal development could constitute a potential risk factor that may conduct to a low sperm count," said Dr. Recabarren.

Low sperm counts are also associated with testicular cancer, with an incidence rate 20 fold higher than men with normal sperm analysis, said Dr. Recabarren. The findings from this study highlight growing concerns of the detrimental effects of prenatal steroid exc
'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Page: 1 2

Related biology news :

1. Primate sperm competition: speed matters
2. Mutant sperm guide clinicians to new diseases
3. Wiggle room: Cornell researcher borrows idea from sperm to provide energy for nanoscale robots
4. Normal-looking sperm may have serious damage; scientists urge more care in selection
5. Diabetes linked to male infertility; excess sugars in the body have direct effect on sperm quality
6. Obese men have less semen, more sperm abnormalities, and should lose weight before trying for a baby
7. Unique study shows oil, gas seismic work not affecting Gulf sperm whales
8. M2SYS Partners With Gnosis Medical Services to Provide Accurate Patient Identification in Developing Countries Through Innovative Biometrics Solution
9. Palm Beach County wants to establish a Max Planck Institute in Florida
10. Data on life expectancy show many countries clustered in high mortality traps
11. Hand hygiene initiative aims to decrease healthcare-associated infection in developing countries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... trees and not just asphalt and recreation equipment reduces ... Colorado Boulder study. , Working on class assignments or ... youth, according to a paper published in the journal ... of the first of its kind to focus on ... stress. , "Many schools already offer stress management programs, ...
(Date:7/22/2014)... meerkats which sees them prevent their daughters from breeding, ... study. , Research into the desert creatures which live ... helpers shows that the alpha female can flourish when ... shows how this way of life, also found in many ... its sinister side. , Dominant meerkats control breeding within ...
(Date:7/22/2014)... much is known about the the genus of planthopper ... a new one was recently discovered in the southern ... of Jaen. A description of it appears in the ... http://www.insectscience.org/14.92/ ). , The new species, Conosimus baenai ... hemipterologist, for his contributions to the taxonomy of Iberian ...
Breaking Biology News(10 mins):Natural-terrain schoolyards reduce children's stress, says Colorado University-Boulder study 2Natural-terrain schoolyards reduce children's stress, says Colorado University-Boulder study 3
... lives and livelihoods of some of the poorest people on ... the Times Higher Education awards ceremony in London, Dr Bhaskar ... and Civil Engineering received the Outstanding Engineering Research Team of ... in tackling the world,s worst case of ongoing mass poisoning ...
... mystery of how an abundance of fossils have been marvellously ... region of Africa has been solved by a team of ... They have established that an ancient wind brought life to ... of the dead. Sarah Gabbott, Jan Zalasiewicz and colleagues ...
... garden bird of many countries in Europe and Asia. ... it has long been known individuals vary considerably in their ... as "fast" or "proactive" are quick explorers and are ... The differences are at least in part genetically determined ...
Cached Biology News:Queen's life-saving research wins education 'Oscar' 2Bird-brained? Birds' personalities are correlated with their hormone levels 2
(Date:7/22/2014)... Massachusetts og SHENZHEN ... Tech Solutions Co., LTD, (BGI Tech), et datterselskab ... lancering af en ny human whole exome-sekvenseringstjeneste baseret ... Complete Genomics, højt anset i branchen for at ... højfølsom registrering af alle typer varianter, blev købt ...
(Date:7/22/2014)... Switzerland (PRWEB) July 22, 2014 ... are becoming an increasingly common sight. The rapid ... they are now well- established as a core ... low maintenance has made them the gas analyzer ... locations and conditions encountered in some processes have ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 Holomic ... with the debut of its fluorescent immunoassay reader, ... Chemistry (AACC) meeting in Chicago, July 28-31, 2014. ... top versions, the HRDR-300 is a highly sensitive, ... to analyze fluorescent lateral flow immunoassays with high ...
(Date:7/21/2014)... 21, 2014 Lawrence Livermore ... Board (WIB) and Las Positas College (LPC) recently ... education and hands-on training for veterans, officials recently ... at Las Positas is designed to help ... engineering technician careers, and establishes a pipeline of ...
Breaking Biology Technology:BGI Tech lancerer Human Whole Exome-sekvenseringstjeneste på Complete Genomics avancerede platform 2METTLER TOLEDO Shows How Tunable Diode Lasers (TDLs) Can Be Installed Where No TDLs Have Gone Before 2Holomic to Debut HRDR-300 Fluorescent Immunoassay Reader at the AACC 2014 2Engineering Program Established for Veterans 2Engineering Program Established for Veterans 3
... to build business through conversion of agricultural ... products into advanced materials, COLUMBUS, Ohio, ... task force aimed at accelerating the state,business climate by maximizing ties ... No. 1 polymer industry., (Logo: http://www.newscom.com/cgi-bin/prnh/20071107/CLW113LOGO ), ...
... Head of PEGylation Business Unit, SAN CARLOS, Calif., ... today that Hoyoung Huh, M.D., Ph.D,is newly appointed to ... Dr.,Huh will step down as Nektar,s Chief Operating Officer ... new leadership role as,President and Chief Executive Officer at ...
... CuraGen Corporation,(Nasdaq: CRGN ) announced today that Timothy ... at the BIO CEO & Investor Conference,on Wednesday, February ... Access to a live webcast of the presentation will ... webcast will be accessible,beginning one hour after the presentation ...
Cached Biology Technology:Ohio Pioneers the Creation of a New 21st Century Industry 2Ohio Pioneers the Creation of a New 21st Century Industry 3Nektar Appoints Hoyoung Huh, M.D., Ph.D., to Serve on the Company's Board of Directors 2