Navigation Links
Low sperm count may be associated with prenatal testosterone excess
Date:9/23/2008

Exposure to an excess of sexual steroids, like testosterone, during fetal development may be a potential risk factor for low sperm count and motility, according to a new study accepted for publication in Endocrinology, a journal of The Endocrine Society.

"The majority of disorders affecting sperm count in humans are originated during fetal life," said Professor Sergio Recabarren of the University of Concepcion in Chillan, Chile and lead author of the study. "A developing fetus is very vulnerable to its environment, and when that environment is exposed to excess sexual steroids, it may have a significant deleterious effect on a male offspring's fertility."

Prenatal exposure to excess sexual steroids can occur in two ways, said Dr. Recabarren. First, the exposure may be a product of increased sexual steroids in the maternal environment due to a hormonal condition such as polycystic ovary syndrome. Second, humans are exposed to several industrial pollutants which can act as steroid mimics, causing the body to inhibit or accelerate native steroid production.

In this study, researchers treated pregnant sheep with 30 mg testosterone propionate twice weekly from days 30 to 90 of pregnancy and with 40 mg testosterone propionate from days 90 to 120 of pregnancy. They found a significant reduction in body weight, scrotal circumference, and sperm count in male sheep born to these mothers compared with control sheep.

"While this research involved sheep, it can certainly be argued that in humans, exposure to an excess of sexual steroids during fetal development could constitute a potential risk factor that may conduct to a low sperm count," said Dr. Recabarren.

Low sperm counts are also associated with testicular cancer, with an incidence rate 20 fold higher than men with normal sperm analysis, said Dr. Recabarren. The findings from this study highlight growing concerns of the detrimental effects of prenatal steroid exc
'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Page: 1 2

Related biology news :

1. Primate sperm competition: speed matters
2. Mutant sperm guide clinicians to new diseases
3. Wiggle room: Cornell researcher borrows idea from sperm to provide energy for nanoscale robots
4. Normal-looking sperm may have serious damage; scientists urge more care in selection
5. Diabetes linked to male infertility; excess sugars in the body have direct effect on sperm quality
6. Obese men have less semen, more sperm abnormalities, and should lose weight before trying for a baby
7. Unique study shows oil, gas seismic work not affecting Gulf sperm whales
8. M2SYS Partners With Gnosis Medical Services to Provide Accurate Patient Identification in Developing Countries Through Innovative Biometrics Solution
9. Palm Beach County wants to establish a Max Planck Institute in Florida
10. Data on life expectancy show many countries clustered in high mortality traps
11. Hand hygiene initiative aims to decrease healthcare-associated infection in developing countries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... Dec. 08, 2014 Research and Markets ... of the "Biometrics Market in Japan 2014-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 The integration ... as rural banking and upgradation of the driver,s ... in the market. Besides the aforementioned projects, biometrics ...
(Date:12/5/2014)... , Dec. 4, 2014  Tute Genomics, a ... $2.3 million in Series A1 funding led by UK-based ... also participated in the investment round. "We ... healthcare community adopts next-generation sequencing and seeks new approaches ... Reid Robison , MD MBA, and CEO of ...
(Date:12/3/2014)... -- As part of our commitment to offering the ... announce the release of a new reader that will ... data that they need. The Atlas 2000 ... readers. Many such devices have serious shortcomings when it ... models force users to navigate numerous complicated steps in ...
Breaking Biology News(10 mins):Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Inception Technologies to Release New Biometric Reader 2
... genetic susceptibility to epilepsy and migraine. Findings published in ... Against Epilepsy (ILAE), indicate that having a strong family ... migraine with aura (MA). Medical evidence has ... this co-occurrence is called "comorbidity." Previous studies have found ...
... individuals with agonizing pain, it is a cruel blow when ... whose pain gets worse when treated with morphine may be ... January 6 on-line edition of Nature Neuroscience . ... can increase pain, and suggests potential new ways to make ...
... . Many of the nation,s foremost authorities on ... the inaugural Cyber Sciences Laboratory workshop. The event will feature ... The Next Threat to National Security and What to do ... 44 research talks and 20 research posters. Researchers from nine ...
Cached Biology News:All in the family: A genetic link between epilepsy and migraine 2The pain puzzle: Uncovering how morphine increases pain in some people 2The pain puzzle: Uncovering how morphine increases pain in some people 3January 2013 story tips from Oak Ridge National Laboratory 2
(Date:12/19/2014)... BioPlus Specialty Pharmacy ... has an expanded team of Regional Pharmaceutical Care ... prescriber offices in their regions, with specific areas ... a variety of Regional Pharmaceutical Care Liaisons specializing ... hepatitis C help prescribers understand all the new ...
(Date:12/19/2014)... 2014 Reports from CDC ... suffer from one or more chronic health conditions - ... can address some of these diseases, but may not ... sufferers face. While implanted nerve stimulation devices today offer ... nerve, which can induce side effects. , To ...
(Date:12/19/2014)... 2014 With only 2 weeks left ... on Sartorius Biohit products . The product specials include ... Electronic Pipette Trade-in Program, and free pipette tips. , ... around the world. They are ideal for lab technicians ... ,     Full volume range of 0.1 uL ...
(Date:12/19/2014)... , Dec. 18, 2014 Relmada Therapeutics, ... for the treatment of chronic pain, announced the results ... "This was a transformational year in Relmada,s ... future for our company," said Sergio Traversa , ... we have executed on key financial, human resource and ...
Breaking Biology Technology:BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 2BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 3Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2
... Amylin Pharmaceuticals,Inc. (Nasdaq: AMLN ) today announced ... Global Healthcare Unplugged Conference in Key,Biscayne, FL to Thursday, ... p.m. PT.,Previously, the presentation had been scheduled for 9:20 ... and Chief Executive Officer of,Amylin Pharmaceuticals, will be providing ...
... DIEGO, April 30 Gen-Probe Incorporated,(Nasdaq: GPRO ) ... Bank 33rd Annual Health Care Conference on May 6 ... to be webcast live,and may be accessed through a ... http://www.gen-probe.com . The webcast will be available for 30,days ...
... Marks a New Step in the Company,s Global ... Sigma-Aldrich (Nasdaq:,SIAL) today announced the full integration of ... brands effective May 1, 2008,( http://www.sigma-aldrich.com/rebranding )., ... our products and,services," said Josef Zihlmann, Global Vice ...
Cached Biology Technology:Gen-Probe to Webcast Presentation at Deutsche Bank 33rd Annual Health Care Conference 2Sigma-Aldrich Announces the Integration of Riedel-De Haen Into Core Product Brands 2Sigma-Aldrich Announces the Integration of Riedel-De Haen Into Core Product Brands 3
... Recognizes K+ Cl- Cotransporter-1 ... no significant sequence homology ... CCC.,SPECIES REACTIVITIES: The immunogen ... in human, mouse, porcine ...
...
Anti-G-alpha-i 1 G-Protein Host: mouse monoclonal Species Reactivity: human, mouse, rat Applications: WB Storage: 4C...
oligophrenin-1 (H-100)...
Biology Products: