Navigation Links
Low oxygen levels may decrease life-saving protein in spinal muscular atrophy
Date:8/21/2012

ecifically to decreases in oxygen. This gave us a clue that low levels of oxygen might influence how the SMN2 gene is spliced."

Upon examining mouse models of severe SMA exposed to low oxygen levels, Dr. Chandler's team found that SMN2 exon 7 skipping increased within skeletal muscles. When the mice were treated with higher oxygen levels, exon 7 was included more often and the mice showed signs of improved motor function.

"These data correspond with the improvements seen in SMA patients who undergo oxygen treatment," says Dr. Chandler. "Our findings suggest that respiratory assistance is beneficial in part because it helps prevent periods of low oxygenation that would otherwise increase SMN2 exon 7 skipping and reduce SMN levels."

Dr. Chandler says daytime indicators that reveal when an SMA patient is experiencing low oxygen levels during sleep may serve as a measure to include SMA patients in earlier respiratory support and therefore improve quality of life or survival.


'/>"/>

Contact: Erin Pope
Erin.Pope@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. Diabetes Research Institute develops oxygen-generating biomaterial
2. Scientists study the catalytic reactions used by plants to split oxygen from water
3. How bacteria change movement direction in response to oxygen: Molecular interactions unravelled
4. PCBs levels down in Norwegian polar bears
5. Growing nitrous oxide levels explained
6. High levels of TRAIL protein in breast milk might contribute to anticancer activity
7. Research!America says house funding levels for FY13 could undermine medical progress
8. Mercury in dolphins: Study compares toxin levels in captive and wild sea mammals
9. Cardio fitness levels of breast cancer patients may affect survival
10. UCSB anthropologists finds high levels of omega-3 fatty acids in breast milk of Amerindian women
11. Increasing levels of carbon dioxide in Arctic coastal seas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/7/2015)... May 7, 2015 Fingerprint ... FPC1022 and FPC1035, FPC,s smallest touch fingerprint sensors ... mainly considered for integration on the backside of ... OEMs increased possibilities to integrate touch fingerprint sensors ... also improves possibilities for module manufacturers to customize ...
(Date:4/27/2015)... LAUDERDALE, Fla. , Apr. 27, 2015 ... of access control and security systems is pleased to ... the company as a consultant and member of its ... is widely known as a thought leader in ... Distance Learning Technology Group, and has published studies and ...
(Date:4/14/2015)... 2015  HYPR Corp. today announced it has ... Alliance tm , an industry consortium transforming online ... share technology and collaborate to deliver open specifications ... secure and private, and easier to use. ... protects sensitive user information and eliminates the dependency ...
Breaking Biology News(10 mins):FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3
... the Midlands Consortium say they are absolutely delighted ... chosen to host a new 1billion national institute ... is comprised of the universities of Birmingham, Loughborough ... extensive and complementary energy related research activities. ...
... on September 27 and 28, when male contraception researchers from ... The second Future of Male Contraception conference sponsored by ... the World Health Organization, and the University of Washington ... Registration is free of charge. Here is a ...
... and Ali Saib are joint winners of the 2007 ... recipients present science in a unique format that is ... the award. Using different media, they have produced resources ... science to the broader community. Professor Ali Saib ...
Cached Biology News:Midlands Consortium delighted to be chosen to host £1 billion energy institute 2Midlands Consortium delighted to be chosen to host £1 billion energy institute 32 French scientists win European award for communication 22 French scientists win European award for communication 3
(Date:5/28/2015)... , May 28, 2015  PDS Biotechnology Corp. ... immunotherapy treatment targeting HPV-16, has generated strong T-cell ... Currently, pre-cervical cancer is treated by surgical removal ... and effective non-surgical alternative. Results show that it ... to recognize, target, and kill precancerous and cancerous ...
(Date:5/28/2015)... , May 28, 2015 Biscayne Pharmaceuticals, ... potential of its growth hormone-releasing hormone (GHRH) technology will ... 2015 ASCO Annual Meeting. The data show that the ... anti-cancer GHRH blockers, is present on many primary breast ... suggest that GHRH antagonists could have broad anti-cancer potential ...
(Date:5/28/2015)... and London (PRWEB) May 28, 2015 ... of Computer Aided Engineering software, announced today it ... Inc. (PSRI). CD-adapco will provide state-of-the-art engineering simulation ... will share their expertise and experiences in analyzing ... refining industry members and advance the understanding of ...
(Date:5/28/2015)... (PRWEB) May 28, 2015 Glenn Keet, ... The Changing Landscape of EMR/EHR Clinical Data Integration with ... taking place in Washington, DC on June 14th-18th. , ... of integrating EMR/EHR systems with EDC, and will examine ... brought by eSource and electronic health records/electronic medical records ...
Breaking Biology Technology:PDS Biotechnology reports positive Phase I clinical trial results in proprietary HPV-Cancer Immunotherapy 2Data Presented At 2015 ASCO Annual Meeting Shows Biscayne Pharmaceuticals' GHRH Antagonist Target Is Expressed Across All Breast Cancer Subtypes 2Data Presented At 2015 ASCO Annual Meeting Shows Biscayne Pharmaceuticals' GHRH Antagonist Target Is Expressed Across All Breast Cancer Subtypes 3CD-adapco and PSRI Chartering New Course in Particle Flow Simulations 2Clinovo Presents at the DIA 2015 51st Annual Meeting in Washington, DC on June 14th-18th 2
... of capturing 10 percent of the stem cell technology market ... directing the Department of Commerce to spend at least $5 ... companies to Wisconsin. , ,Doyle said the executive order, signed ... to stem cell research. Proponents of stem cell research cite ...
... might suspect, I'm a bit proprietary about the companies that have ... have great news and always sorry when a company hits the ... a good week when so many of my "children" see the ... month for DEMO companies on the fund-raising circuit. Jingle Networks ...
... days of Marco Polo, if not well before. It started ... to finished products. Next came financial capital. In more recent ... have gone global. What's different today from the past is ... perceived opportunities are vast but there are downsides as well, ...
Cached Biology Technology:Doyle authorizes $5 million to woo stem cell companies 2A windfall of funds for DEMO companies 2A windfall of funds for DEMO companies 3Learning to swim in the global talent pool 2Learning to swim in the global talent pool 3Learning to swim in the global talent pool 4
Sufficient reagents for 50 applications.Mitochondria Isolation Kit Reagent A, 50 ml Mitochondria Isolation Kit Reagent B, 500 l Mitochondria Isolation Kit Reagent C, 70 ml...
... cassette is designed to allow ampicillin selection ... gb2 driving the gene for ampicillin resistance ... Em7 promoter. It mediates higher transcription efficiency ... synthetic polyadenylation signal terminates the ampicillin expression. ...
... can be difficult to achieve in many ... one or more restriction and modification (R-M) ... recognized as "foreign". TypeOne™ Restriction Inhibitor provides ... in bacterial strains with type I R-M ...
... Y is most widely used in ... and differentially stain nucleic acids following ... dye solution, Pyronin Y stains RNA ... green. Chem comp: Dye ...
Biology Products: