Navigation Links
Low levels of key protein may indicate pancreatic cancer risk
Date:8/15/2007

BOSTON--A protein that dwindles in response to obesity and a sedentary lifestyle may one day help doctors predict which people are at increased risk for pancreatic cancer, new research by Dana-Farber Cancer Institute and collaborating scientists indicates.

In a report in the Aug. 15 issue of Cancer Research, the investigators found that, in a large study group, people with the lowest blood levels of a protein called IGFBP-1 were twice as likely to develop pancreatic cancer as those with higher levels. Though much work remains to determine if the protein -- whose acronym stands for insulin-like growth factor binding protein-1 -- is a reliable indicator of pancreatic cancer risk, the finding adds to the scientific understanding of how the disease develops.

"The levels of insulin and another circulating hormone, insulin-like growth factor or IGF, are modified by obesity and sedentary lifestyle, and there is evidence that these hormones may stimulate the growth of pancreatic cancer cells," said the study's lead author, Brian Wolpin, MD, of Dana-Farber. "When IGF binds to proteins like IGFBP-1, there may be less IGF available to bind to pancreatic cancer cells and promote their growth. We wanted to determine whether IGFBP-1 levels in the blood were associated with pancreatic cancer risk."

The investigators measured circulating IGFBP-1 levels in a select group of participants in four large, ongoing health studies: the Health Professionals Follow-up Study, the Nurses' Health Study, the Physicians' Health Study, and the Women's Health Initiative. They collected blood samples from 573 participants and, four or more years later, checked IGFBP-1 levels in the samples of 144 people who developed pancreatic cancer and 429 who did not.

They found that the quarter of the group whose IGFBP-1 levels were lowest had twice the risk of developing pancreatic cancer of those in the top three quarters. The connection became even stronger over time: Among cases diagnosed at least eight years after blood collection, those in the bottom quarter of IGFBP-1 levels had nearly three-and-a-half times the pancreatic cancer risk of those in the upper quarters.

The risk may be elevated because higher amounts of IGFBP-1 are able to "soak up" more IGF, leaving less available to spur pancreatic cancer cell growth, or because IGFBP-1 has some cancer-blocking properties of its own, said Wolpin, who is also an instructor in medicine at Harvard Medical School. Another possibility is that other molecules may be involved, for which IGFBP-1 acts as an intermediary.

"It's known that a variety of proteins are affected by obesity and sedentary lifestyle," he added. "Studies are exploring whether a subset of these may play a role in the risk of developing pancreatic cancer. More research is also needed on how alterations in insulin and proteins in the IGF family alter the risk of this difficult disease."


'/>"/>
Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert

Related biology news :

1. New lab technique identifies high levels of pathogens in therapy pool
2. Scientists at Galileo Pharmaceuticals confirm inflammatory response linked to glucose levels
3. MERIS monitoring tracks planetary photosynthesis levels
4. High carbon dioxide levels spur Southern pines to grow more needles
5. Enzyme affects hypertension by controlling salt levels in body
6. Field tested: Grasslands wont help buffer climate change as carbon dioxide levels rise
7. Babys genes affect moms cholesterol levels
8. Males with elevated levels of testosterone lead shorter lives but have more success siring offspring
9. Salmonella bacteria use RNA to assess and adjust magnesium levels
10. Fish on acid: Hagfish cope with high levels of CO2
11. High estrogen levels associated with dementia in older men
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... PUNE, India , January 19, 2017 ... Sensor Market, Opportunities and Forecast, 2014 - 2022," the global biometric sensor ... of 9.6% from 2016 to 2022. In 2015, Asia-Pacific ... for both public and private sectors. Continue Reading ... ...
(Date:1/19/2017)... 19, 2017 Sensory Inc ., ... security for consumer electronics, and i ... and cybersecurity solutions, today announced a global partnership ... institutions worldwide to bolster security of data sensitive ... user authentication platforms they offer, innerCore now offers ...
(Date:1/18/2017)... Jan. 18, 2017  In vitro diagnostic (IVD) companies ... and acquisitions (M&A), and Kalorama Information expects that trend ... have been shifting. Generally, uncertainty in reimbursement and healthcare ... U.S. has changed the acquisitions landscape. Instead of looking ... companies buying partners outside of their home country and ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... (PRWEB) , ... January 18, 2017 , ... ... again at the CHI SCOPE Summit for Clinical Ops Executives (Hyatt Regency Miami, ... panel discussions to examine vital clinical research issues such as trial performance metrics, ...
(Date:1/18/2017)... ... January 18, 2017 , ... uBiome, the ... paper by its Science Editor, Dr. Elisabeth Bik, in the December 2016 issue ... Bik joined uBiome in October 2016 from her previous position at Stanford University ...
(Date:1/18/2017)... Jan. 18, 2017 Shareholder rights law firm ... whether the board members of CoLucid Pharmaceuticals, Inc. (NASDAQ: ... connection with the proposed sale of the Company to ... that develops small molecules for the acute treatment of ... it had signed a definitive merger agreement with Eli ...
(Date:1/18/2017)... IRVING, Texas , Jan. 18, 2017 /PRNewswire/ ... science, and the Lustgarten Foundation, the largest private ... support a clinical trial evaluating the impact of ... is providing clinical trial enrollment services to identify ... and facilitate communication between treating physicians and study ...
Breaking Biology Technology: