Navigation Links
Low ghrelin -- reducing appetite at the cost of increased stress?
Date:9/13/2012

Philadelphia, PA, September 13, 2012 Ghrelin is a hormone released by the lining of the stomach that promotes feeding behavior. Decreasing ghrelin levels could potentially help combat obesity -- in fact, a vaccine that lowers ghrelin levels in order to reduce appetite is being studied as a treatment for obesity.

However, many people eat as a way to relieve stress. If low ghrelin levels increase stress, its effectiveness as a treatment for obesity may be reduced. In the current issue of Biological Psychiatry, researchers led by Dr. Zane Andrews of Monash University in Australia show that mice with no ghrelin are more anxious after stress, but that administration of endogenous ghrelin prevents the over-anxious response.

Previous studies have indicated that ghrelin can be either anxiety-causing or anxiety-relieving. This new set of studies now reveals that this dual role in anxiety behavior is context-dependent. Under non-stressed conditions, normal mice show mild anxiety relative to mice without ghrelin. Under acute stress, normal mice mount an appropriate ghrelin response to stress and are less anxious than no-ghrelin mice. In other words, stress-induced ghrelin release targets the body's stress system to stimulate a hormonal response that will combat the stress.

Ghrelin promotes the drive for food intake and maintains blood glucose during negative energy balance as well as subserving the rewarding nature of food. "We postulate that, under conditions of acute stress, ghrelin limits excessive anxious behavior by promoting the feeling of reward to ensure appropriate food-seeking behavior and maintain energy homeostasis. Consistent with this idea, studies from Jeff Zigman and colleagues showed that elevated ghrelin during calorie restriction produced anxiolytic responses in a test of anxious behavior," said Andrews.

"We hypothesize that ghrelin suppresses anxiety under acutely stressful conditions to encourage food seeking and maintain appropriate energy homeostasis. Indeed, the importance of ghrelin in controlling stress-induced anxiety might manifest only during conditions of elevated plasma ghrelin, such as negative energy balance and calorie restriction," he continued. "This phenomenon represents an important evolutionary adaptation that maintains food-seeking behavior in the face of acutely stressful environments."

"This study highlights the complexity of approaches for reducing the epidemic in obesity," commented Dr. John Krystal, Editor of Biological Psychiatry. "In this case, low ghrelin levels stimulate anxiety and anxiety is a factor that increases food consumption in humans, particularly sweet and fatty comfort foods. These studies highlight complex relationships between systems in the body and brain that regulate mood and food consumption."


'/>"/>
Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Related biology news :

1. Researchers find reducing fishmeal hinders growth of farmed fish
2. Reducing traffic at 2008 Olympics yielded large cut in CO2
3. The appetite-suppressing effect of proteins explained
4. Increased fructose consumption may deplete cellular energy in patients with obesity and diabetes
5. NIH-led study finds genetic test results do not trigger increased use of health services
6. New research finds increased growth responsible for color changes in coral reefs
7. Specific toxic byproduct of heat-processed food may lead to increased body weight and diabetes
8. Increased sediment and nutrients delivered to bay as Susquehanna reservoirs near sediment capacity
9. Sick from stress? Blame your mom… and epigenetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... N.Y. and ITHACA, N.Y. ... ) and Cornell University, a leader in dairy research, ... with bioinformatics designed to help reduce the chances that ... With the onset of this dairy project, Cornell University ... Consortium for Sequencing the Food Supply Chain, a food ...
(Date:5/16/2017)... 2017   Bridge Patient Portal , an ... MD EMR Systems , an electronic medical record ... have established a partnership to build an interface ... GE Centricity™ products, including Centricity Practice Solution (CPS), ... These new integrations will allow healthcare delivery networks ...
(Date:4/18/2017)... , April 18, 2017  Socionext Inc., a global expert in ... media edge server, the M820, which features the company,s hybrid codec ... provided by Tera Probe, Inc., will be showcased during the upcoming ... NAB show at the Las Vegas Convention ... Click ...
Breaking Biology News(10 mins):
(Date:9/20/2017)... CT (PRWEB) , ... September 20, 2017 , ... ... announced today that it has appointed Vishwas Paralkar to the role of chief ... tumor targeting technology. He will report to Cybrexa’s president and CEO, Per Hellsund. ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... effects of exoskeleton-assisted walking on gait parameters and neuromuscular activity in able-bodied ... during a robotic powered exoskeleton assisted walking session" (doi:10.1080.10790268.2017.1314900) was epublished ahead ...
(Date:9/19/2017)... ... September 19, 2017 , ... The ... most dangerous step of sample prep for metals digestion—the addition of acids and ... an affordable price. The system is ideal for any laboratory performing their own ...
(Date:9/19/2017)... IL (PRWEB) , ... September 19, 2017 , ... The ... environments and time. The pocket testers even stand upright with a new cap design ... lab or out in the field who need to test water quality. , The ...
Breaking Biology Technology: