Navigation Links
Low ghrelin -- reducing appetite at the cost of increased stress?
Date:9/13/2012

Philadelphia, PA, September 13, 2012 Ghrelin is a hormone released by the lining of the stomach that promotes feeding behavior. Decreasing ghrelin levels could potentially help combat obesity -- in fact, a vaccine that lowers ghrelin levels in order to reduce appetite is being studied as a treatment for obesity.

However, many people eat as a way to relieve stress. If low ghrelin levels increase stress, its effectiveness as a treatment for obesity may be reduced. In the current issue of Biological Psychiatry, researchers led by Dr. Zane Andrews of Monash University in Australia show that mice with no ghrelin are more anxious after stress, but that administration of endogenous ghrelin prevents the over-anxious response.

Previous studies have indicated that ghrelin can be either anxiety-causing or anxiety-relieving. This new set of studies now reveals that this dual role in anxiety behavior is context-dependent. Under non-stressed conditions, normal mice show mild anxiety relative to mice without ghrelin. Under acute stress, normal mice mount an appropriate ghrelin response to stress and are less anxious than no-ghrelin mice. In other words, stress-induced ghrelin release targets the body's stress system to stimulate a hormonal response that will combat the stress.

Ghrelin promotes the drive for food intake and maintains blood glucose during negative energy balance as well as subserving the rewarding nature of food. "We postulate that, under conditions of acute stress, ghrelin limits excessive anxious behavior by promoting the feeling of reward to ensure appropriate food-seeking behavior and maintain energy homeostasis. Consistent with this idea, studies from Jeff Zigman and colleagues showed that elevated ghrelin during calorie restriction produced anxiolytic responses in a test of anxious behavior," said Andrews.

"We hypothesize that ghrelin suppresses anxiety under acutely stressful conditions to encourage food seekin
'/>"/>

Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers find reducing fishmeal hinders growth of farmed fish
2. Reducing traffic at 2008 Olympics yielded large cut in CO2
3. The appetite-suppressing effect of proteins explained
4. Increased fructose consumption may deplete cellular energy in patients with obesity and diabetes
5. NIH-led study finds genetic test results do not trigger increased use of health services
6. New research finds increased growth responsible for color changes in coral reefs
7. Specific toxic byproduct of heat-processed food may lead to increased body weight and diabetes
8. Increased sediment and nutrients delivered to bay as Susquehanna reservoirs near sediment capacity
9. Sick from stress? Blame your mom… and epigenetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... , March 23, 2015  In the 2014 fiscal ... case conviction losses. This figure accounts for a fraction ... to The Nilson Report, exceeds $11 billion globally. The ... after a crime has occurred. Investor Mark Saint ... expert Joe Paolella partnered to administer the ...
(Date:3/20/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces its biometric payment technology, ... featured in 2015 "I Want That" International CES Special, ... the DIY Network.   DIY,s "I Want ... site of the 2015 International CES for a firsthand ...
(Date:3/17/2015)... , March 17, 2015 ... company specializing in clinical study management systems, is ... in attendance at ARENA,s Outsourcing in Clinical Trials ... This event provides an excellent forum for MedNet ... flexible and affordable software-as-a-service (SaaS) eClinical technology platform. ...
Breaking Biology News(10 mins):Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2
... PITTSBURGHCarnegie Mellon University,s John Kitchin was awarded $750,000 ... of Energy for developing new materials for producing ... was elated to hear that my research had been ... professor in Chemical Engineering at Carnegie Mellon. "This ...
... distinctive red soils could play a part in the formation ... off east coast beaches in summer., A QUT team of ... gives our iron-rich soil its red colour, reaches water to ... a foul smell, but also make our eyes sting, cause ...
... This release is available in German . ... decreased over recent decades. In fact, the number of beekeepers has ... the result of a study that has now been published by ... provided an overview of the problem of bee colony decline at ...
Cached Biology News:Carnegie Mellon's John Kitchin receives early career award 2Is iron from soil a factor in algal blooms? 2Fewer honey bee colonies and beekeepers throughout Europe 2Fewer honey bee colonies and beekeepers throughout Europe 3
(Date:4/23/2015)... 23, 2015 Six startups from ... April 4-17 as part of the U.S.-Russia Innovation ... group of biotechnology startups to participate in the ... (UNN) and the University of Maryland (UMD) signed ... their respective universities in the biomedical industry in ...
(Date:4/23/2015)... 2015  Cryoport, Inc. (OTCBB: CYRX) ("Company"), the ... the life sciences industry, today announced that the ... within the animal husbandry market by signing a ... the shipment of equine semen for artificial insemination ... Animal husbandry is a multi-billion dollar ...
(Date:4/23/2015)... Irvine, CA (PRWEB) April 23, 2015 ... research leader in Personalized Medicine, is excited to ... Medication Response profile . This profile assesses 62 ... and provide dosing information for commonly prescribed non-opioid ... gabapentin (brand name Neurontin), alprazolam (brand name Xanax) ...
(Date:4/23/2015)... ReliantHeart's HeartAssist5® Ventricular Assist Device (VAD) ... the device) in real time, and this data is ... provider of Machine to Machine (M2M) communications for the ... VADLink.com can be monitored by a patient’s ... flow below a minimum threshold, the patient can be ...
Breaking Biology Technology:U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 2U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 3U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 4Cryoport to Support the Equine Animal Husbandry Market Through Agreement with Yancey Farms 2Cryoport to Support the Equine Animal Husbandry Market Through Agreement with Yancey Farms 3Proove Biosciences Launches World’s First Test to Predict Responders to Commonly Prescribed Non-Opioid Pain Medications 2Proove Biosciences Launches World’s First Test to Predict Responders to Commonly Prescribed Non-Opioid Pain Medications 3
... 3SBio Inc.,(Nasdaq: SSRX ) ("3SBio" or ... focused on researching, developing, manufacturing and,marketing biopharmaceutical ... board of directors has approved a share ... 3SBio to purchase up to US$20 million ...
... Genomas(R), a,biomedical company advancing DNA-guided medicine and ... Phase I-II Small,Business Innovation Research (SBIR) Grant totaling ... Statin Safety and Efficacy," was,awarded by the National ... are the most prescribed drugs in the world. ...
... to Attend April Meeting,in St. Louis, DANBURY, ... (SBS) today announced its outstanding roster of,keynote speakers ... be held,April 6-10 at America,s Center in St. ... and biotech industries from around the world are,expected ...
Cached Biology Technology:3SBio Inc. Approves Share Repurchase Program 2Genomas Awarded $1.2 Million NIH SBIR Grant to Develop DNA-Guided System for Management of Statin Therapy 2Society for Biomolecular Sciences Announces 2008 Conference Speaker Line-up 2
... designed for stabilizing the coating biomolecules ... immunoassay development. It can stabilize ... and drying process and for long ... works as a blocking agent to ...
... The Freedom EVO Clinical is Tecans open ... to enhance quality, safety and performance in ... Safety is provided by flexible barcode reading ... to mention that the system complies with ...
... is one of the smallest thermal cyclers on ... of either the 0.5ml (20 samples) or 0.2ml ... Fast heating and cooling rate of 3.6C/sec ... high performance Fast track programming with new ...
... cycler, flexible on your protocols, easy on your ... high sample throughput instrument at a highly affordable ... format: The truly user-friendly fully interchangeable block system ... of seconds without the need of any tools ...
Biology Products: